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WD repeat and FYVE domain containing 3

BWF1, Alfy
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, CD4, AGE, V1a
Papers on BWF1
A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production.
Minato et al., Kyoto, Japan. In J Immunol, Jul 2015
These unique TF cells with essentially similar features increase much earlier and are accumulated in the spontaneous germinal centers (GCs) in lupus-prone female BWF1 (f-BWF1) mice.
Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).
Li et al., Shijiazhuang, China. In In Vitro Cell Dev Biol Anim, Mar 2015
Autophagy-linked FYVE (Alfy) is a protein implicated in the selective degradation of aggregated proteins.
Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFκB and ERK.
Mahmoud et al., Asyūţ, Egypt. In Plos One, 2014
In the current study, we further investigated B cell autoreactivity in female BWF1 lupus mice after infection with either live or gamma-irradiated malaria, using ELISA, flow cytometry and Western blot analysis.
Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis.
Lanza et al., Marlborough, United States. In Sci Rep, 2014
Here, we show that hESC-MSCs prevent the progression of fatal lupus nephritis (LN) in NZB/W F1 (BWF1) mice.
ERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase.
Roth et al., Seoul, South Korea. In Histochem Cell Biol, 2014
It colocalizes with the selective autophagy cargo receptors p62/SQSTM1, neighbor of BRCA1 gene 1 (NBR1) and autophagy-linked FYVE (Alfy) protein, and becomes engulfed by autophagic isolation membranes.
Dendritic and stromal cells from the spleen of lupic mice present phenotypic and functional abnormalities.
Bono et al., Santiago, Chile. In Mol Immunol, 2013
We analyzed the phenotype and distribution of two main DC subsets, conventional (cDC) and plasmacytoid (pDC), in lupus prone (NZW × NZB)F1 (BWF1) mice and age-matched NZW × BALB/c control mice.
Lupus-prone strains vary in susceptibility to antibody-mediated end organ disease.
Mohan et al., Dallas, United States. In Genes Immun, 2013
BWF1 and B6.Yaa mice exhibited intermediate degrees of GN that was comparable to the B6 controls.
Blimp-1 siRNA inhibits B cell differentiation and prevents the development of lupus in mice.
Hu et al., Jinan, China. In Hum Immunol, 2013
To explore the potential of Blimp-1 in the SLE development, we constructed the adenovirus encoding Blimp-1 siRNA, and injected it into BWF1 lupus mice.
Malarial infection of female BWF1 lupus mice alters the redox state in kidney and liver tissues and confers protection against lupus nephritis.
Badr et al., Riyadh, Saudi Arabia. In Oxid Med Cell Longev, 2012
We have measured changes in the levels of nitric oxide (NO), hydrogen peroxide (H2O2), malondialdehyde (MDA), and reduced glutathione (GSH) in both kidney and liver tissues of female BWF1 lupus mice, an experimental model of SLE, after infection with either live or gamma-irradiated malaria.
Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus.
Halder et al., In Arthritis Res Ther, 2012
METHODS: We introgressed the β2m-null genotype onto the NZB and NZW backgrounds for 12 to 14 generations to generate genetically lupus-susceptible (NZB/NZW)F1 (BWF1) mice that are β2m-deficient (β2m°).
Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus.
Laguna et al., Barcelona, Spain. In Plos One, 2011
Using the BWF1 mouse, which develops MS and SLE, we sought a molecular connection to explain the prevalence of these two diseases in the same individuals.
Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?
Simonsen et al., New York City, United States. In Autophagy, 2011
increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
Yamamoto et al., Oslo, Norway. In Mol Cell, 2010
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
Johansen et al., Tromsø, Norway. In Autophagy, 2010
Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.
Aberrant B1 cell trafficking in a murine model for lupus.
Matsushima et al., Tokyo, Japan. In Front Biosci, 2006
B lymphocyte chemoattractant (BLC/CXCL13) is ectopically and highly expressed in the target organs such as the thymus and kidney in aged (NZB x NZW)F1 (BWF1) mice, a murine model for SLE.
Cellular and molecular mechanisms of regulation of autoantibody production in lupus.
La Cava et al., Los Angeles, United States. In Ann N Y Acad Sci, 2005
Each of these lymphocyte subsets suppresses anti-DNA antibody production and delays the onset of nephritis in BWF1 lupus-prone mice.
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.
Stenmark et al., Oslo, Norway. In J Cell Sci, 2004
Alfy might target cytosolic protein aggregates for autophagic degradation.
Expression profile of mouse BWF1, a protein with a BEACH domain, WD40 domain and FYVE domain.
Muramatsu et al., Nagoya, Japan. In Cell Struct Funct, 2004
gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 and E16 embryonic brain, but became diffuse after birth
Structural considerations of autoantibodies.
Naparstek et al., Philadelphia, United States. In Lupus, 2001
The mechanisms responsible for peptide-induced immunosuppression lupus-prone BWF1 mice were determined to be mediated via recognition by T cells, although the response was peptide-specific, as some accelerated the autoimmune response.
Lessons from the NZM2410 model and related strains.
Wakeland et al., Gainesville, United States. In Int Rev Immunol, 1999
The main advantages presented by this strain over other models are the genetic homozygozity at all loci and an highly penetrant early onset lupus nephritis in both males and females, indicating that the strongest BWF1 susceptibility loci were retained in NZM2410.
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