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Smu-1 suppressor of mec-8 and unc-52 homolog

BWD, SMU-1, fSAP57
involved in protein-protein interaction in the brain [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, ACID, p21, Cho, SET
Papers on BWD
Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.
Naffakh et al., Paris, France. In Plos Pathog, 2014
Here we identify two human spliceosomal factors, RED and SMU1, that control the expression of NS2/NEP and are required for efficient viral multiplication.
Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint.
Li et al., Chengdu, China. In Biochem Biophys Res Commun, 2013
Smu1 is an evolutionarily conserved gene that encodes a member of the WD40-repeat protein family.
Cla4, but not Rac1, regulates the filamentous response of Ustilago maydis to low ammonium conditions.
Perlin et al., Louisville, United States. In Commun Integr Biol, 2011
Smu1 is a p21-activated protein kinase (PAK) with roles in both the mating response required for the former function, as well as for the nutrient response.
Role of Hsl7 in morphology and pathogenicity and its interaction with other signaling components in the plant pathogen Ustilago maydis.
Perlin et al., Louisville, United States. In Eukaryot Cell, 2011
The PAK-like Ste20 homologue Smu1 is required for a normal response to pheromone, via upregulation of pheromone expression, and virulence, and its disruption affects both processes.
Enlargement of speckles of SF2/ASF due to loss of function of Smu1 is characterized in the mammalian temperature-sensitive mutant.
Sugaya et al., Chiba, Japan. In Rna Biol, 2011
An amino acid substitution in Smu1 underlying the ts phenotypes of tsTM18 cells was identified previously.
Plant SMU-1 and SMU-2 homologues regulate pre-mRNA splicing and multiple aspects of development.
Larkins et al., Tucson, United States. In Plant Physiol, 2009
Taken together, our data indicated that the plant SMU-1 and SMU-2 homologues appear to be involved in splicing of specific pre-mRNAs that affect multiple aspects of development.
Context-dependent modulation of cutaneous reflex amplitudes during forward and backward leg cycling.
Loadman et al., Victoria, Canada. In Motor Control, 2009
We used amplitude modulation of cutaneous reflexes during leg cycling as a paradigm to investigate neural control mechanisms regulating forward (FWD) and backward (BWD) rhythmic limb movement.
A genetic screen for suppressors of a mutated 5' splice site identifies factors associated with later steps of spliceosome assembly.
Zahler et al., Santa Cruz, United States. In Genetics, 2009
SMU-2 binds SMU-1, and smu-1(RNAi) also leads to suppression of e936.
Analysis of chromatin structure of genes silenced by heterochromatin in trans.
Csink et al., Pittsburgh, United States. In Genetics, 2008
An insertion of heterochromatic satellite DNA in the euchromatic brown (bw) gene of Drosophila melanogaster results in bwDominant (bwD), which can inactivate loci on the homolog by relocation near the centric heterochromatin (trans-inactivation). Nucleosomal compaction was found to accompany trans-inactivation, but stereotypical heterochromatic histone modifications were mostly absent on silenced reporter genes.
The conserved role of Smu1 in splicing is characterized in its mammalian temperature-sensitive mutant.
Tsuji et al., Chiba, Japan. In J Cell Sci, 2007
Temperature-sensitive CHO-K1 mutant cell line tsTM18 exhibits chromosomal instability and cell-cycle arrest at S and G2 phases with decreased DNA synthesis at the nonpermissive temperature, 39 degrees C. We previously identified an amino acid substitution in Smu1 that underlies the temperature-sensitive phenotypes of tsTM18 cells.
A temperature-sensitive mutation in the WD repeat-containing protein Smu1 is related to maintenance of chromosome integrity.
Tsuji et al., Chiba, Japan. In Exp Cell Res, 2005
Analysis of chromosome content of temperature-resistant transformants and introduction of a bacterial artificial chromosome containing part of human chromosome 9 led to isolation of the human SMU1 gene.
Alternative splicing in C. elegans.
Zahler, Santa Cruz, United States. In Wormbook, 2004
Factors involved in alternative splicing that are discussed include mec-8, smu-1, smu-2, fox-1, exc-7 and unc-75.
SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice.
Shaw et al., Minneapolis, United States. In Mol Cell Biol, 2004
The effects of smu-2 mutation on both unc-52 pre-mRNA splicing and the suppression of mec-8 and unc-52 mutant phenotypes are indistinguishable from the effects of mutation in smu-1, a gene that encodes a protein that is 62% identical to human spliceosome-associated protein fSAP57.
An ste20 homologue in Ustilago maydis plays a role in mating and pathogenicity.
Perlin et al., Louisville, United States. In Eukaryot Cell, 2004
Disruption of the gene smu1 resulted in a delayed mating response in a mating-type-specific manner and also in a severe reduction in disease production on maize.
Clinical and genetic heterogeneity in chromosome 9p associated hereditary inclusion body myopathy: exclusion of GNE and three other candidate genes.
Kimonis et al., Boston, United States. In Neuromuscul Disord, 2003
Mutation analysis in three other candidate genes (beta-tropomyosin, NDUFB6 and SMU1) did not identify any mutations.
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