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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Budding uninhibited by benzimidazoles 1 homolog beta

Bub1, BubR1, BUB1B
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Mad2, Cdc20, CAN, Bub3, Adenylate Cyclase
Papers using Bub1 antibodies
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... ), mouse anti-B56α (BD), mouse anti-Bub1 (Abcam), mouse anti-BubR1 (Millipore), mouse ...
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
Vallee Richard B. et al., In The Journal of Cell Biology, 2002
... Reiner, Weizmann Institute, Rehovot, Israel), monoclonal anti-BUBR1 (BD Biosciences), chicken anti-GFP (Chemicon), monoclonal ...
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
Zachos George et al., In The Journal of Cell Biology, 2000
... Monoclonal antibody to CENP-A (3–19) and polyclonal antibodies against human Aurora B (ab2254) and murine BubR1 (ab28193) were obtained from Abcam.
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
van Deursen Jan M. et al., In The Journal of Cell Biology, 2000
... Generation of Bub1 transgenic mice ...
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
Kellermayer Miklos S., In PLoS ONE, 1999
... Mouse anti-BubR1 IgG was obtained from BD Biosciences, CA, USA ...
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Papers on Bub1
Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex.
Hershko et al., Haifa, Israel. In Proc Natl Acad Sci U S A, Feb 2016
MCC is composed of the checkpoint proteins BubR1, Bub3, and Mad2, associated with the APC/C coactivator Cdc20.
Disruptive selection without evolution across a migratory divide.
Wolf et al., Germany. In Mol Ecol, Feb 2016
Among breeding populations a single outlier locus mapped to the BUB1 gene with a role in mitotic and meiotic organization.
Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells.
Chung et al., Taiwan. In Environ Toxicol, Jan 2016
The cell-division cycle protein 20 (CDC20), Budding uninhibited by benzimidazole 1 homolog beta (BUB1B), and cyclin B1 were downregulated, and clusterin was upregulated in GBM 8401 cells treated with PEITC.
Expression data of HeLa cells treated with CENP-E siRNA or Eg5 siRNA in the presence of BubR1 siRNA.
Ohashi et al., Fujisawa, Japan. In Genom Data, Dec 2015
The molecular mechanism responsible for cell fate after mitotic slippage is unclear.
Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents.
Xu et al., Beijing, China. In Eur J Med Chem, Dec 2015
Treatment of HT29 cells with 5c resulted in BubR1 phosphorylation and an increase of mitotic index in a time-dependent manner.
BubR1 kinase: protection against aneuploidy and premature aging.
Bolanos-Garcia et al., Boston, United States. In Trends Mol Med, Jun 2015
The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle.
Prognostic factors of survival rate in oral squamous cell carcinoma: clinical, histologic, genetic and molecular concepts.
Yazdi et al., Tehrān, Iran. In Arch Iran Med, May 2015
Among well-known molecular markers, cyclin dependent kinase, survivin, CD44, BUBR1, and heat shock proteins (27,70) can be considered as independent prognostic factors of survival rate.
The role of BUB and CDC proteins in low-grade breast cancers.
Ellis et al., Nottingham, United Kingdom. In Lancet, Mar 2015
METHODS: The Nottingham Tenovus Primary Breast Cancer Series (n=1858) microarrays were immunostained for BUB (BUB1, BUB1B, BUB3) and CDC proteins (CDC2, CDC42) and expression correlated with clinicopathological and molecular variables and patient outcome (SPSS, version 22).
How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models.
Lee, Seoul, South Korea. In Mol Cells, 2014
Here, I will review on the recent progress on the understanding of chromosome mis-segregation and cancer, based on the comparison of different mouse models of BubR1, the core component of SAC.
The dynamic protein Knl1 - a kinetochore rendezvous.
Bolanos-Garcia et al., Québec, Canada. In J Cell Sci, 2014
We present emerging roles of the protein interaction motifs present in Knl1, including the RVSF, SILK, MELT and KI motifs, and their role in the recruitment and regulation of the SAC proteins Bub1, BubR1, Bub3 and Aurora B. Finally, we explore how the regions of low structural complexity that characterize Knl1 are implicated in the cooperative interactions that mediate binding partner recognition and scaffolding activity by Knl1.
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
van Deursen et al., Rochester, United States. In Nat Cell Biol, 2013
The BubR1 gene encodes for a mitotic regulator that ensures accurate segregation of chromosomes through its role in the mitotic checkpoint and the establishment of proper microtubule-kinetochore attachments.
New insights into the role of BubR1 in mitosis and beyond.
Rahmani et al., Paris, France. In Int Rev Cell Mol Biol, 2012
BubR1 is a critical component of the spindle assembly checkpoint, the surveillance mechanism that helps maintain the high fidelity of mitotic chromosome segregation by preventing cells from initiating anaphase if one or more kinetochores are not attached to the spindle.
CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.
Mao et al., New York City, United States. In J Cell Biol, 2012
It was shown that the state of CENP-E-dependent BubR1 autophosphorylation in response to spindle microtubule capture by CENP-E is important for kinetochore function in achieving accurate chromosome segregation.
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
Kops et al., Utrecht, Netherlands. In Dev Cell, 2012
It was shown that Mad3/BUBR1 and BUB1 paralogous pairs arose by nine independent gene duplications throughout evolution. It was also shown that putative catalysis by human BUBR1 is dispensable for error-free chromosome segregation.
Bub1 kinase and Sgo1 modulate pericentric chromatin in response to altered microtubule dynamics.
Bloom et al., Chapel Hill, United States. In Curr Biol, 2012
Bub1 and Sgo1 act as a rheostat to regulate the chromatin spring and maintain force balance. Through histone H2A S121 phosphorylation and recruitment of Sgo1, Bub1 kinase softens the chromatin spring in response to changes in microtubule dynamics.
Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing.
Dai et al., New York City, United States. In Cell Cycle, 2012
Results reveal that BubR1 sumoylation plays an important role in its timely removal from the kinetochores and the checkpoint inactivation, thus allowing normal anaphase entry and chromosome segregation.
BubR1 is modified by sumoylation during mitotic progression.
Dai et al., New York City, United States. In J Biol Chem, 2012
a new type of post-translational modification that is essential for BubR1 function during mitosis.
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
van Deursen et al., Rochester, United States. In Nature, 2011
Here we show that in the BubR1 progeroid mouse background, INK-ATTAC removes p16(Ink4a)-positive senescent cells upon drug treatment.
Physiological relevance of cell cycle kinases.
Malumbres, Madrid, Spain. In Physiol Rev, 2011
Here, we review the physiological relevance of mammalian cell cycle kinases such as cyclin-dependent kinases (Cdks), Aurora and Polo-like kinases, and mitotic checkpoint regulators (Bub1, BubR1, and Mps1) as well as other less-studied enzymes such as Cdc7, Nek proteins, or Mastl and their implications in development, tissue homeostasis, and human disease.
Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation.
Kapoor et al., New York City, United States. In Nat Cell Biol, 2011
By uncoupling the checkpoint from its primary error signal, we show that Aurora, Mps1 and BubR1 kinases, but not Polo-like kinase, are needed to maintain checkpoint arrest when Mad1 is present on kinetochores.
More papers using Bub1 antibodies
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker ofchemo therapy-induced apoptosis
Aneja Ritu et al., In Molecular Cancer, 1992
... BubR1 was purchased from BD Biosciences, PharMingen ...
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