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Butyrophilin, subfamily 1, member A1

Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, CD45, V1a, ACID
Papers on BTN
Matrix-based three-dimensional culture of buffalo mammary epithelial cells showed higher induction of genes related to milk protein and fatty acid metabolism.
Mukesh et al., Karnāl, India. In Cell Biol Int, Feb 2016
The expression of milk casein genes viz., alpha S1-casein (CSN1S1), alpha S2-casein (CSN1S2), beta-casein (CSN2), kappa-casein (CSN3); and fatty acid metabolism genes viz., butyrophilin (BTN1A1), glycerol-3-phosphate acyltransferase (GPAM), fatty acid-binding protein 3 (FABP3), and stearoyl-CoA desaturase (SCD) was assessed in 3D culture in comparison to traditional monolayer culture using qRT-PCR.
Regulation of Immunity by Butyrophilins.
Trowsdale et al., Cambridge, United Kingdom. In Annu Rev Immunol, Feb 2016
UNASSIGNED: Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the eponymous protein in cow's milk.
Diagnostic significance of elevated expression of HBME-1 in papillary thyroid carcinoma.
Chen et al., Xi'an, China. In Tumour Biol, Feb 2016
A total of 206 patients were enrolled in the current study including 96 PTC patients and 110 patients with benign thyroid nodules (BTN).
Sensitivity improvement of a sandwich-type ELISA immunosensor for the detection of different prostate-specific antigen isoforms in human serum using electrochemical impedance spectroscopy and an ordered and hierarchically organized interfacial supramolecular architecture.
Hernández-López et al., Mexico. In Anal Chim Acta, Feb 2016
The electrode was then exposed to serum samples at different concentrations of a sandwich-type immunocomplex molecule ((Btn)Ab-AgPSA-(HRP)Ab), and its interfacial properties were characterized using electrochemical impedance spectroscopy (EIS).
TROP-2 expression in papillary thyroid carcinoma: Potential Diagnostic Utility.
Siddiqui et al., Atlanta, United States. In Diagn Cytopathol, Jan 2016
Immunohistochemical (IHC) evaluation for TROP-2 was performed on 137 thyroid fine needle aspiration (FNA) cell blocks (CB) which included classic PTC (64), follicular variant PTC (FVPTC) (10), anaplastic thyroid carcinoma (AC) (2), medullary carcinoma (MC) (8), follicular neoplasms (FN) (8), Hurthle cell neoplasms (HCN) (9), follicular lesion of uncertain significance (FLUS) (12), and benign thyroid nodule (BTN) (24).
Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells.
Morita et al., Iowa City, United States. In J Immunol, Dec 2015
The Ig superfamily protein butyrophilin (BTN)3A1 was shown to be required for prenyl pyrophosphate stimulation.
The effect of heat stress on gene expression and synthesis of heat-shock and milk proteins in bovine mammary epithelial cells.
Wang et al., Beijing, China. In Anim Sci J, Nov 2015
The major milk protein genes of β-casein (CSN2) and butyrophilin (BTN1A1) were down-regulated and the synthesis of total caseins was decreased.
Biotinylated heptapeptides substituted with a D-amino acid as platelet-activating factor inhibitors.
Ebina et al., Iwaki, Japan. In Eur J Pharmacol, Nov 2015
In this study, synthetic heptapeptides (Lys-Trp-Tyr-Lys-Asp-Gly-Asp) coupled to a biotin molecule through the N-terminal amino group and ε-amino group of N-terminus Lys, (Btn)KP6 and K(Btn)P6, respectively, and their biotinylated peptides substituted with D-Lys at the N-terminus, (Btn)dKP6 and dK(Btn)P6, respectively, were investigated for their effects on PAF-induced inflammation.
Transdermal delivery of bovine milk vesicles in patients with multiple sclerosis: A novel strategy to induce MOG-specific tolerance.
Ahmadi et al., Sanandaj, Iran. In Med Hypotheses, Aug 2015
Recently, butyrophilin (BTN) - a protein which shares cross-reactive epitopes with myelin oligodendrocyte glycoprotein (MOG) - has been found in milk.
Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters.
Kadam et al., Baltimore, United States. In Front Cell Neurosci, 2014
To investigate ischemia-induced seizure susceptibility and efficacy of the GABAA-agonist phenobarbital (PB), with NKCC1 antagonist bumetanide (BTN) as an adjunct treatment, we utilized permanent unilateral carotid-ligation to produce acute ischemic-seizures in post-natal day 7, 10, and 12 CD1 mice.
Molecules and Mechanisms Implicated in the Peculiar Antigenic Activation Process of Human Vγ9Vδ2 T Cells.
Scotet et al., Bethesda, United States. In Front Immunol, 2013
The recent identification of B7-related butyrophilin (BTN) molecules CD277/BTN3A, and more precisely their BTN3A1 isoforms, as mandatory molecules in the phosphoAg-induced recognition of target cells by Vγ9Vδ2 T cells opens important opportunities for research and applications in this field.
Phosphoantigen Presentation to TCR γδ Cells, a Conundrum Getting Less Gray Zones.
Mori et al., Singapore, Singapore. In Front Immunol, 2013
Recent studies have identified butyrophilin (BTN) 3A1 as the molecule necessary to stimulate Vγ9Vδ2 cells.
The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response.
Olive et al., Marseille, France. In Immunogenetics, 2012
Butyrophilins (BTN) belong to the immunoglobulin (Ig) superfamily of transmembrane proteins.
Butyrophilins: an emerging family of immune regulators.
Bas et al., London, United Kingdom. In Trends Immunol, 2012
This review addresses each of these issues, concluding with the attractive potential of Btn and Btnl molecules to act as specific attenuators of tissue-associated inflammatory responses.
Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
Hixon et al., Providence, United States. In Plos One, 2010
Data illustrated the importance of Akt1 in mammary epithelial cell proliferation, as well as in the regulation of Btn1a1 and subsequent expression of ss-casein.
BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.
Trowsdale et al., Cambridge, United Kingdom. In J Immunol, 2010
These data are consistent with a coinhibitory role for mouse Butyrophilins
The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues.
Mather et al., College Park, United States. In J Biol Chem, 2009
PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase
Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?
Trowsdale et al., Cambridge, United Kingdom. In Immunology, 2005
We show that while SPRY domains are evolutionarily ancient, B30.2 domains, found in BTN and TRIM proteins, are a more recent evolutionary adaptation, comprising the combination of SPRY with an additional domain, PRY.
Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets.
Mather et al., College Park, United States. In Proc Natl Acad Sci U S A, 2004
expression of Btn1a1 is essential for the regulated secretion of milk-lipid droplets.
Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis.
Linington et al., Martinsried, Germany. In J Immunol, 2004
BTN present in milk and dairy products may influence the composition and function of myelin oligodendrocyte glycoprotein (MOG)-specific autoimmune repertoire during the course of multiple sclerosis.
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