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Bombesin-like receptor 3

BRS-3, bombesin receptor subtype 3
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Bombesin, Gastrin, gastrin-releasing peptide receptor, neuromedin B, neuromedin B receptor
Papers on BRS-3
Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells.
Jensen et al., Bethesda, United States. In Peptides, Jan 2016
Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein coupled receptor which is classified in the bombesin receptor (BnR) family with which it shares high homology.
Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes.
Egido et al., Madrid, Spain. In Int J Mol Med, Apr 2015
Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein-coupled receptor (GPCR) member of the bombesin receptor family.
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.
Jensen et al., Bethesda, United States. In Peptides, Feb 2015
BRS-3 is an orphan GPCR and little is known of its physiological role due to the lack of specific agonists and antagonists.
Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach.
Takahashi et al., Tokyo, Japan. In Bioorg Med Chem, 2015
Novel compounds based on the lead BRS-3 agonists from our HTS compounds 2a and 2b have been synthesized with the focus on obtaining peripheral BRS-3 agonists.
Bombesin receptor subtype 3 as a potential target for obesity and diabetes.
Jensen et al., Madrid, Spain. In Expert Opin Ther Targets, 2014
It involves recognition of the central role the G-protein-coupled receptor, bombesin receptor subtype 3 (BRS-3) plays in energy/glucose metabolism.
Search for an Endogenous Bombesin-Like Receptor 3 (BRS-3) Ligand Using Parabiotic Mice.
Reitman et al., Bethesda, United States. In Plos One, 2014
Bombesin-like receptor 3 (BRS-3) is an X-linked G protein-coupled receptor involved in the regulation of energy homeostasis.
Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors.
Yanagisawa et al., Tokyo, Japan. In Plos One, 2014
Utilizing this system, we screened various mammalian tissue extracts for agonistic activities on human bombesin receptor subtype 3 (hBRS3).
Extraintestinal roles of bombesin-like peptides and their receptors: lung.
Qu et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, 2013
Recent studies also shed light on the intracellular signaling pathways of bombesin receptor subtype-3 (BRS-3) activation in cultured human lung cancer cells.
The role of bombesin and bombesin-related peptides in the short-term control of food intake.
Sayegh, United States. In Prog Mol Biol Transl Sci, 2012
These peptides evoke a number of responses, including hyperthermia, bradycardia, inhibition of gastric emptying and inhibition of food intake, by activating one of three G protein-coupled receptors: an NMB-R or BB(1), a GRP-R or BB(2) and an orphan Bn receptor subtype-3 (BRS-3) or BB(3).
(68)Ga-labeled bombesin analogs for receptor-mediated imaging.
Mishra et al., Delhi, India. In Recent Results Cancer Res, 2012
The three bombesin receptors GRP, NMB, and BRS-3 receptor are most frequently ectopically expressed by common, important malignancies.
Appetite-modifying effects of bombesin receptor subtype-3 agonists.
Weber et al., Boston, United States. In Handb Exp Pharmacol, 2011
Pharmacological experiments in vitro and in vivo as well as utilization of genetic rodent models of the gastrin-releasing peptide receptor (GRP-R/BB2-receptor), neuromedin B receptor (NMB-R/BB1-receptor), and the bombesin receptor subtype-3 (BRS-3/BB3-receptor) further delineated their role in health and disease.
Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.
Zhou et al., Rahway, United States. In Endocrinology, 2011
These results identify a potential role for BRS-3 in islet physiology, with agonism directly promoting glucose-stimulated insulin secretion
Activation of bombesin receptor subtype-3 influences activity of orexin neurons by both direct and indirect pathways.
Sakurai et al., Kanazawa, Japan. In J Mol Neurosci, 2010
Data suggest that the bombesin receptor subtype-3 agonist indirectly inhibited orexin neurons through GABAergic input and directly activated orexin neurons.
Treating obesity? It's in the bag!
Coll, Cambridge, United Kingdom. In Cell Metab, 2010
BRS-3 is an orphan G protein coupled receptor highly expressed in the brain.
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Reitman et al., Rahway, United States. In Cell Metab, 2010
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown.
Factors contributing to obesity in bombesin receptor subtype-3-deficient mice.
Moran et al., Baltimore, United States. In Endocrinology, 2008
Hyperphagia is a major factor leading to increased body weight and hyperinsulinemia in BRS-3 KO mice.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Benya et al., Bethesda, United States. In Pharmacol Rev, 2008
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)).
BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts.
Qin et al., Changsha, China. In Cell Biol Int, 2007
The secretion of TGF-beta1 increased and the synthesis of PGE2 decreased from BRS-3-activated BEC, which were correlated with the proliferation and collagen synthesis of HLF.
PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.
Weber et al., Changsha, China. In Biochem J, 2007
Data suggest that activator protein 2alpha and peroxisome-proliferator-activated receptor alpha may be especially involved in the ozone-inducible up-regulation mechanism of bombesin receptor subtype 3 expression.
Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.
Wada et al., Kodaira, Japan. In Nature, 1997
Bombesin-like peptide receptors cloned so far include, gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R), and bombesin receptor subtype-3 (BRS-3).
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