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POU domain, class 3, transcription factor 3

Brn-1, brain-1, POU3F3
acts as a transcriptional activator in oligodendrocytes; may play a role in regulation of neural development [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Brn-2, Tbr1, ICOS, OCT, V1a
Papers on Brn-1
Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO.
Hevner et al., Seattle, United States. In Dev Neurobiol, Nov 2015
We examine Ca(2+) fluctuations in the first postnatal week of normal mouse neocortex and that expressing knockout of the transcription factor T-brain-1 (Tbr1): a signaling molecule in cortical patterning and differentiation of excitatory neurons.
Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer.
Chen et al., Guangzhou, China. In Oncotarget, Nov 2015
Here, we investigated the association of linc-POU3F3 and prognosis in CRC.
Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma.
Xu et al., Nanjing, China. In Tumour Biol, Mar 2015
Some lncRNAs, such as HOTAIR and POU3F3, were reported to play important roles in ESCC.
Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma.
Zhu et al., Nanchang, China. In Gene, 2015
Long intergenic noncoding RNA POU3F3 (linc-POU3F3) has been characterized as a highly conserved functional transcription regulator in esophageal squamous cell carcinoma.
Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders.
Hsueh et al., Taipei, Taiwan. In Front Neurosci, 2014
T-brain-1 (TBR1) is a brain-specific T-box transcription factor.
Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma.
Cao et al., Nanjing, China. In Mol Cancer, 2014
METHODS: Ten lncRNAs (HOTAIR, AFAP1-AS1, POU3F3, HNF1A-AS1, 91H, PlncRNA1, SPRY4-IT1, ENST00000435885.1,
Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation.
Kamma et al., Kami-renjaku, Japan. In Pathol Int, 2014
Because class III POU genes (POU3F1, POU3F2, POU3F3, and POU3F4) and class IV POU genes (POU4F1, POU4F2, and POU4F3) share similar properties in neural development, we analyzed the association between class III/IV POU genes and a proneural/neuroendocrine phenotype in lung cancers using seven small cell lung cancer (SCLC) cell lines and twelve non-SCLC (NSCLC) cell lines.
Neuronal excitation upregulates Tbr1, a high-confidence risk gene of autism, mediating Grin2b expression in the adult brain.
Hsueh et al., Taipei, Taiwan. In Front Cell Neurosci, 2013
T-brain-1 (TBR1), a critical neuron-specific transcription factor for forebrain development, has been recognized as a high-confidence risk gene for autism spectrum disorders.
The long non-coding RNA Dali is an epigenetic regulator of neural differentiation.
Ponting et al., Oxford, United Kingdom. In Elife, 2013
Dali is transcribed downstream of the Pou3f3 transcription factor gene and its depletion disrupts the differentiation of neuroblastoma cells.
Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium.
Matsunaga et al., Tokyo, Japan. In Dev Neurobiol, 2009
Pou3f3 may be important for the maintenance or functional development of the postnatal cochlea. This is the first report to study involvement of an epigenetic regulatory mechanism in the developing mammalian auditory epithelium.
Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.
Wegner et al., Erlangen, Germany. In Dev Biol, 2009
Data show that Oct-6 normally represses Wnt1 expression in the early diencephalon and replacement by Brn-1 as a weaker inhibitor is no longer sufficient to maintain the necessary level of repression in the mouse mutant.
Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.
Jing et al., Shanghai, China. In J Biol Chem, 2009
Sox2 and SF1 may mediate basal nestin expression in undifferentiated cells, whereas Sox2, Brn1, and Brn2 bind to the enhancer in neural progenitor cells.
Transcriptional control of terminal nephron differentiation.
Saifudeen et al., New Orleans, United States. In Am J Physiol Renal Physiol, 2008
While some of these factors (the p53 gene family, hepatocyte nuclear factor-1beta) promote the terminal epithelial differentiation fate, others (Notch, Brn-1, IRX, KLF4, and Foxi1) tend to regulate differentiation of specific nephron segments and individual cell types.
Expression of Sox11 and Brn transcription factors during development and following transient forebrain ischemia in the rat.
Kim et al., South Korea. In Neurosci Lett, 2008
Collectively, overall results suggest that the expression of Sox11 and Brn1 may be modulated by the cell-type specific machinery.
[Functional characteristics of the individual genomic condensin binding sites of Saccharomyces cerevisiae using minichromosome mitotic segregation stability model].
Strunnikov et al., In Tsitologiia, 2007
Individual contribution of condensin binding sites in securing mitotic stability of the minichromosomes.
Transcriptional regulation of cortical neuron migration by POU domain factors.
Rosenfeld et al., San Diego, United States. In Science, 2002
Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons
Expression of transcription factors during oligodendroglial development.
Wegner, Erlangen, Germany. In Microsc Res Tech, 2001
Once turned on, expression of these proteins can either be permanent as in the above-mentioned cases or transient as exemplified by the POU domain proteins Tst-1/Oct6/SCIP, Brn-1 and Brn-2.
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.
Froguel et al., Lausanne, Switzerland. In Nat Genet, 2000
Islet-brain-1 (IB1, encoded by MAPK8IP1), a novel DNA-binding transactivator of the glucose transporter GLUT2 (encoded by SLC2A2), is the homologue of the c-Jun amino-terminal kinase-interacting protein-1 (JIP-1; refs 2-5).
Transcriptional control of cell phenotypes in the neuroendocrine system.
Scully et al., San Diego, United States. In Recent Prog Horm Res, 1995
Neurons comprising the endocrine hypothalamus develop in tandem with their ultimate target, the pituitary gland, and arise from a primordium in which three related class III POU domain factors-Brn-2, Brn-4, and Brn-1-are initially co-expressed.
Functional domains in the oxytocin gene for regulation of expression and biosynthesis of gene products.
Adan et al., Utrecht, Netherlands. In Adv Exp Med Biol, 1994
In the distal 5' flanking region the POU class III proteins Brn-1, Brn-2, Brn-4, that are expressed in magnocellular neurons, and Oct-6 are able to bind, but do not display a significant regulatory activity on the OT gene in heterologous expression systems.
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