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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Zinc finger protein 36, C3H type-like 2

Brf2, TIS11d, ZFP36L2, ERF-2, BRFU
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: tristetraprolin, POLYMERASE, CAN, IRF, TBP
Papers on Brf2
Emergence and evolution of Zfp36l3.
Blackshear et al., United States. In Mol Phylogenet Evol, Jan 2016
We provide evidence that Zfp36l3 arose by retrotransposition of an mRNA encoded by a related gene, Zfp36l2 into an ancestral rodent X chromosome.
BRF2 Is a Redox-Sensing RNA Pol III Core Transcription Factor.
In Cancer Discov, Jan 2016
UNASSIGNED: The DNA-bound BRF2-TBP complex crystal structure reveals a redox-sensing function of BRF2.
Three Residues Make an Evolutionary Switch for Folding and RNA-Destabilizing Activity in the TTP Family of Proteins.
Massi et al., Worcester, United States. In Acs Chem Biol, Jan 2016
The TTP protein family in humans includes two other proteins, TIS11b and TIS11d.
Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.
Vannini et al., Lausanne, Switzerland. In Cell, Jan 2016
TFIIB-related factor 2 (Brf2) is a member of the family of TFIIB-like core transcription factors.
Probing the structural and dynamical effects of the charged residues of the TZF domain of TIS11d.
Massi et al., Worcester, United States. In Biophys J, Apr 2015
A member of the TTP family of proteins, TIS11d binds RNA with high specificity using a pair of CCCH-type tandem zinc fingers separated by a 18 residue long linker.
Identification of common regulators of genes in co-expression networks affecting muscle and meat properties.
Wimmers et al., Germany. In Plos One, 2014
Zfp36l2 was confirmed as a regulator of genes of a module related to cell death or apoptosis pathways.
Functional regulation of Zfp36l1 and Zfp36l2 in response to lipopolysaccharide in mouse RAW264.7 macrophages.
Chang et al., Taipei, Taiwan. In J Inflamm (lond), 2014
BACKGROUND: The tristetraprolin (TTP) family of mRNA-binding proteins contains three major members, Ttp, Zfp36l1, and Zfp36l2.
Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification.
Reis-Filho et al., New York City, United States. In Genome Biol, 2014
In vitro experiments provided functional evidence to suggest that BRF2 and DSN1 overexpression/amplification, and the HER2 I767M mutation may be alterations that compensate for the lack of HER2 amplification in the HER2-negative components of HER2 heterogeneous breast cancers.
Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein.
Schramm et al., New York City, United States. In Bmc Cancer, 2014
BACKGROUND: BRF2 is a transcription factor required for synthesis of a small group of non-coding RNAs by RNA polymerase III.
Phylogenetic distribution and evolution of the linked RNA-binding and NOT1-binding domains in the tristetraprolin family of tandem CCCH zinc finger proteins.
Perera et al., United States. In J Interferon Cytokine Res, 2014
In humans, the tristetraprolin or TTP family of CCCH tandem zinc finger (TZF) proteins comprises 3 members, encoded by the genes ZFP36, ZFP36L1, and ZFP36L2.
ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors.
Lodish et al., Cambridge, United States. In Nature, 2013
Here we show that the RNA-binding protein ZFP36L2 is a transcriptional target of the glucocorticoid receptor (GR) in BFU-Es and is required for BFU-E self-renewal.
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
Chang et al., Taipei, Taiwan. In Int J Biol Sci, 2011
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
Demiryurek et al., Gaziantep, Turkey. In Endocr Pathol, 2011
ZFP36L2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia.
Asou et al., Kumamoto, Japan. In Int J Oncol, 2011
Data suggest that the dysregulation of TIS11D function is associated with the pathogenesis of certain types of leukemia.
The roles of TTP and BRF proteins in regulated mRNA decay.
Dixon et al., Columbia, United States. In Wiley Interdiscip Rev Rna, 2011
The roles of TTP and BRF proteins in regulated mRNA decay.
RNA polymerase III transcription in cancer: the BRF2 connection.
Schramm et al., Frederick, United States. In Mol Cancer, 2010
Recently, BRF2, a component of TFIIIB required for gene external RNA pol III transcription, was identified as an oncogene in squamous cell carcinomas of the lung through integrative genomic analysis.
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.
Turner et al., Cambridge, United Kingdom. In Nat Immunol, 2010
ZFP36L2 has a critical role in lymphocyte development and may function as a tumor suppressor.
Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.
Lam et al., Vancouver, Canada. In Plos Med, 2010
BRF2 can serve as a marker for lung squamous cell carcinoma and may provide a novel target for therapy.
Multiple modes of RNA recognition by zinc finger proteins.
Hall, United States. In Curr Opin Struct Biol, 2005
Recent structural studies of the C(2)H(2) zinc fingers of transcription factor IIIA (TFIIIA) and the CCCH zinc fingers of Tis11d in complex with their RNA targets have revealed new modes of zinc finger interaction with nucleic acid.
Zinc finger proteins: getting a grip on RNA.
Brown, Boston, United States. In Curr Opin Struct Biol, 2005
Additionally, the NMR structure of TIS11d bound to an AU-rich element reveals the molecular details of the interaction between CCCH fingers and single-stranded RNA.
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