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Signal transducing adaptor family member 1

BRDG1, STAP-1, BCR downstream signaling 1, signal-transducing adaptor protein-1
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, Hgb, Tec, BCR, FMS
Papers on BRDG1
Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction.
Schunkert et al., L├╝beck, Germany. In Eur J Hum Genet, Feb 2016
Eight variants were previously reported as disease-causing and three are novel (LDLR.c.811G>A p.(V271I)), PCSK9.c.610G>A (p.(D204N)) and STAP1.c.139A>G (p.(T47A))).
Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia.
Hovingh et al., Amsterdam, Netherlands. In Circ Res, 2014
METHODS AND RESULTS: Parametric linkage analysis combined with exome sequencing in a FH4 family resulted in the identification of the variant p.Glu97Asp in signal transducing adaptor family member 1 (STAP1), encoding signal transducing adaptor family member 1. Sanger sequencing of STAP1 in 400 additional unrelated FH4 probands identified a second p.Glu97Asp carrier and 3 additional missense variants, p.Leu69Ser, p.Ile71Thr, and p.Asp207Asn.
Mucosal plasma cell barrier disruption during intestine transplant rejection.
Sindhi et al., Pittsburgh, United States. In Transplantation, 2013
RESULTS: Among 107 differentially expressed genes, three B-cell lineage-specific genes, CCR10, STAP1, and IGLL1, were down-regulated during ITx rejection and were selected for and achieved technical quantitative reverse transcription polymerase chain reaction replication.
Loops govern SH2 domain specificity by controlling access to binding pockets.
Li et al., London, Canada. In Sci Signal, 2009
The structure of the SH2 domain of BRDG1 bound to a peptide revealed a binding pocket that was blocked by a loop residue in most other SH2 domains.
Induction of STAP-1 promotes neurotoxic activation of microglia.
Langmann et al., Regensburg, Germany. In Biochem Biophys Res Commun, 2009
Taken together, this study implicates a previously unknown role of STAP-1 in pro-inflammatory microglia activation potentially contributing to neuronal apoptosis and degeneration.
Defining the specificity space of the human SRC homology 2 domain.
Li et al., London, Canada. In Mol Cell Proteomics, 2008
We identified a number of novel binding motifs, which are exemplified by the BRDG1 SH2 domain that selects specifically for a bulky, hydrophobic residue at P + 4 relative to the Tyr(P) residue.
Physical and functional interactions between STAP-2/BKS and STAT5.
Matsuda et al., Sapporo, Japan. In J Biol Chem, 2005
STAP-1 has been shown to interact with STAT5 and the tyrosine kinase Tec.
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.
Dikic et al., Frankfurt am Main, Germany. In Mol Biol Cell, 2004
These effectors include phosphatidyl-inositol phosphatases SHIP-1 and synaptojanin 2B1, Arf GTPase-activating proteins ASAP1 and ARAP3, adaptor proteins Hip1R and STAP1, and a Rho exchange factor, p115Rho GEF.
STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.
Yoshimura et al., Fukuoka, Japan. In J Biol Chem, 2003
STAP-2 is structurally related to STAP-1/BRDG1 (BCR downstream signaling-1), which we had cloned previously from hematopoietic stem cells.
Isoform-dependent interaction of BRDG1 with Tec kinase.
Tokuhisa et al., Chiba, Japan. In Biochem Biophys Res Commun, 2001
We previously identified one of the downstream messengers for human Tec kinase, BRDG1.
Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
Osawa et al., Kurume, Japan. In Biochem Biophys Res Commun, 2000
By screening with c-kit as bait, we cloned a novel cDNA, designed STAP-1, encoding an adaptor protein with a Pleckstrin homology domain, the Src homology 2 (SH2) domain, and a number of tyrosine phosphorylation sites.
Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.
Mano et al., Tochigi, Japan. In Proc Natl Acad Sci U S A, 1999
The yeast two-hybrid system has identified several proteins that interact with the kinase domain of Tec, one of which is now revealed to be a previously unknown docking protein termed BRDG1 (BCR downstream signaling 1).
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