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Hyaluronan and proteoglycan link protein 2

Bral1, HAPLN2, brain link protein-2, brain link protein-1
mouse homolog is a brain-specific hyaluronan-binding protein that may play a role in neuronal conduction [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, tenascin-R, HAPLN4, SPINK5, Neurocan
Papers on Bral1
Bral1: "Superglue" for the extracellular matrix in the brain white matter.
Vargova et al., Praha, Czech Republic. In Int J Biochem Cell Biol, 2012
Bral1 is a link protein that stabilizes the binding between lecticans and hyaluronic acid and thus maintains the extracellular matrix assembly in the CNS.
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.
Andreassen et al., Oslo, Norway. In Biol Psychiatry, 2011
METHODS: Ten genes of importance for HNK-1 biosynthesis (B3GAT1, B3GAT2, and CHST10) or for the formation of perineuronal nets (TNR, BCAN, NCAN, HAPLN1, HAPLN2, HAPLN3, and HAPLN4) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects).
Bral1: its role in diffusion barrier formation and conduction velocity in the CNS.
Oohashi et al., Okayama, Japan. In J Neurosci, 2010
These findings provide an understanding of the mechanisms underlying the accumulation of cations due to diffusion barriers around the nodes during saltatory conduction, emphasizing the importance of the Bral1-based extramilieu for neuronal conductivity.
Neurocan contributes to the molecular heterogeneity of the perinodal ECM.
Oohashi et al., Okayama, Japan. In Arch Histol Cytol, 2009
Double immunolabeling for neurocan and a nodal marker, Bral1, or a paranodal marker, caspr, demonstrated that neurocan was localized at the node of Ranvier.
Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.
Viapiano et al., Columbus, United States. In J Biol Chem, 2009
Results indicate that HAPLN4 and HAPLN2 are the predominant members of this family in the adult human brain but are strongly reduced in the tumor parenchyma.
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
Dias-Neto et al., São Paulo, Brazil. In J Neural Transm, 2009
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS.
Oohashi et al., Okayama, Japan. In J Neurochem, 2009
The versican V2 and Bral1 distribution was not affected, thus indicating a brevican-independent role of these two molecules for establishing hyaluronan-binding matrices at the nodes.
Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord.
Fawcett et al., Cambridge, United Kingdom. In Eur J Neurosci, 2008
In situ hybridization showed that aggrecan and cartilage link protein (CRTL 1) and brain link protein-2 (BRAL 2) are produced by neurons.
Proteomic analysis of nicotine-associated protein expression in the striatum of repeated nicotine-treated rats.
Hahm et al., South Korea. In Biochem Biophys Res Commun, 2005
The 3 up- and 4 down-regulated proteins were selected and identified to be zinc-finger binding protein-89 (ZBP-89), 2'3'-cyclic nucleotide 3'-phosphodiesterase 1, deoxyribonuclease 1-like 3 (DNase1l3), tandem pore domain halothane inhibited K(+) channel (THIK-2), brain-specific hyaluronan-binding protein (BRAL-1), death effector domain-containing DNA binding protein (DEDD), and brain-derived neurotrophic factor (BDNF) by mass spectrophotometric fingerprinting.
A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.
Bowling et al., Houston, United States. In J Biol Chem, 2003
Two of the four link protein genes (HAPLN2 and HAPLN4) were restricted in expression to the brain/central nervous system, while one of the four genes (HAPLN3) was widely expressed.
Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.
Ninomiya et al., Okayama, Japan. In Acta Med Okayama, 2002
gene locus at chromosome 1q21-23.
Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems.
Ninomiya et al., Okayama, Japan. In Mol Cell Neurosci, 2002
colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems.
The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.
Ninomiya et al., Okayama, Japan. In Biochem Biophys Res Commun, 2000
We report here molecular cloning and expression analysis of the gene for a novel human brain link protein-1 (BRAL1) which is predominantly expressed in brain.
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