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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Bradykinin receptor B1

bradykinin receptor, B1R, bradykinin B1 receptor
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Angiotensin II, B2 receptor, HAD, CAN, V1a
Papers on bradykinin receptor
Nanofiltrated C1-esterase-inhibitor in the prophylactic treatment of bradykinin-mediated angioedema.
Strassen et al., Ulm, Germany. In Transfusion, Feb 2016
Current therapy consists of B2 bradykinin receptor antagonists, C1-esterase-inhibitor (C1-INH) concentrate, or the kallikrein inhibitor ecallantide.
Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice.
Liu et al., Xi'an, China. In Int J Mol Med, Feb 2016
Moreover, the mRNA and protein expression levels of bradykinin receptor B1 (BK1R)/bradykinin receptor B2 (BK2R) and EphB2/EphrinB2 were significantly decreased in the osteoblasts following exposure to high glucose.
Highly effective detection of inflamed cells using a modified bradykinin ligand labeled with FITC fluorescence.
Pack et al., South Korea. In Enzyme Microb Technol, Jan 2016
In this study, we developed an effective imaging system for detection of inflamed cells using a bradykinin ligand (BK) or a modified BK (mBK), which has specific affinity with the cellular B1R receptor.
Analgesic and anti-inflammatory effects of UP1304, a botanical composite containing standardized extracts of Curcuma longa and Morus alba.
Jia et al., Seattle, United States. In J Integr Med, Jan 2016
CONCLUSION: Data presented here suggest that UP1304, analgesic and anti-inflammatory agent of botanical origin, acted as a bradykinin receptor B1 and B2 antagonist, and inhibited COX and LOX enzyme activities.
Protective function of Pirfenidone and Everolimus on the development of chronic allograft rejection after experimental lung transplantation.
Lehle et al., Regensburg, Germany. In Histol Histopathol, Jan 2016
On POD 20, all groups showed severe acute rejection (ISHLT A3-4/B1R-B2R).
Glioblastoma-mesenchymal stem cell communication modulates expression patterns of kinin receptors: Possible involvement of bradykinin in information flow.
Ulrich et al., São Paulo, Brazil. In Cytometry A, Jan 2016
MMP9 expression is in line with significantly increased expression of kinin B1 (B1R) and B2 receptor (B2R) in U87-MG cells and their decreased levels in MSC, as confirmed by quantitative assessment using flow cytometric analysis.
Impairing effects of angiotensin-converting enzyme inhibitor Captopril on bone of normal mice.
Zhang et al., Nantong, China. In Eur J Pharmacol, Jan 2016
This study was aimed to investigate the effect of ACEI, Captopril, on bone metabolism and histology as well as the action of Captopril on skeletal renin-angiotensin system (RAS) and bradykinin receptor pathway in normal male mice.
Delayed onset muscle soreness: Involvement of neurotrophic factors.
Taguchi et al., Kasugai, Japan. In J Physiol Sci, Nov 2015
With our model we have found that two pathways are involved in inducing mechanical hyperalgesia after LC: activation of the B2 bradykinin receptor-nerve growth factor (NGF) pathway and activation of the COX-2-glial cell line-derived neurotrophic factor (GDNF) pathway.
Novel potential treatment modalities for ocular hypertension: focus on angiotensin and bradykinin system axes.
Sharif, Houston, United States. In J Ocul Pharmacol Ther, Apr 2015
Here, some contextual introductory information is provided first, followed by more detailed discussion of the properties and actions of diminazene aceturate (DIZE; a novel angiotensin-converting enzyme-2 activator) and FR-190997 (a nonpeptide bradykinin receptor-2 agonist) in relation to their anti-OHT activities in rodent and cynomolgus monkey eyes, respectively.
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
de Vries et al., Amsterdam, Netherlands. In Drug Resist Updat, Mar 2015
We provide an overview on methods to overcome the BBTB, including osmotic blood-brain barrier disruption (BBBD), bradykinin receptor-mediated BBTB opening, inhibition of multidrug efflux transporters, receptor-mediated transport systems and physiological circumvention of the BBTB.
Recombinant human C1 esterase inhibitor for the treatment of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE).
Craig et al., Penn Hills, United States. In Expert Rev Clin Immunol, Mar 2015
Plasma kallikrein inhibitor (ecallantide) and bradykinin receptor antagonist (icatibant) are both effective for treatment of acute attacks, but their short half-life limits the use for prophylaxis.
Roles of kinins in the nervous system.
Ulrich et al., São Paulo, Brazil. In Cell Transplant, 2014
This peptide is also an important player in spinal cord injury pathophysiology and recovery, in which bradykinin receptor blockers represent substantial therapeutic potential.
Expression patterns of kinin-dependent genes in endometrial cancer.
Mazurek et al., Sosnowiec, Poland. In Int J Gynecol Cancer, 2012
The transcriptional activity of the B1 receptor for kinins increased in patients with grade 1 and grade 2 endometrial cancer when compared to the control group, whereas it decreased in patients with grade 3 endometrial cancer.
Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways.
Calixto et al., Florianópolis, Brazil. In Br J Pharmacol, 2012
Inflammatory muscle pain involves a cascade of events that is dependent on the activation of PKC, p38 and JNK, and the synthesis of IL-1beta, TNF-alpha and IL-6 associated with the up-regulation of both B(1) and B(2) kinin receptors.
Expression of HER2 and bradykinin B₁ receptors in precursor lesions of gallbladder carcinoma.
Poblete et al., Valdivia, Chile. In World J Gastroenterol, 2012
The up-regulation of HER2 and B(1)R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis.
Bradykinin-evoked scratching responses in complete Freund's adjuvant-inflamed skin through activation of B1 receptor.
Ji et al., Guangzhou, China. In Exp Biol Med (maywood), 2012
B(1) and B(2) receptors play different roles in modulating bradykinin-induced itch-related behavior in complete Freund's adjuvant-inflamed mice.
Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptors.
Stein et al., Berlin, Germany. In Anesthesiology, 2012
In knockout mice lacking both B1 and B2 kinin receptors baseline nociceptive responses to heat were unaltered, nocifensive responses to bradykinin are abolished, and acute acetic acid-induced visceral nociception is reduced by approximately 70%.
Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.
Feener et al., Boston, United States. In Nat Med, 2007
CA-I-induced retinal edema was decreased by complement 1 inhibitor, neutralizing antibody to prekallikrein and bradykinin receptor antagonism.
Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough.
Barnes et al., London, United Kingdom. In Nat Med, 1996
Treatment of guinea pigs for two weeks with captopril led to an increased cough response to inhaled citric acid, which was prevented by concomitant treatment with the bradykinin receptor antagonist icatibant.
Regulation of prostaglandin synthesis mediated by thrombin and B2 bradykinin receptors in a fibrosarcoma cell line.
Baenziger et al., In Cell, 1982
HSDM1C1 cells possess a B2 bradykinin receptor, a type more sensitive to native bradykinin than to related peptides, including Met-Lys- and desArg9-bradykinin.
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