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Bol, boule-like

This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DAZ, CAN, MEN, HAD, V1a
Papers on BOULE
Bone morphogenetic protein 4 (BMP4) induces buffalo (Bubalus bubalis) embryonic stem cell differentiation into germ cells.
Chauhan et al., Karnāl, India. In Biochimie, Dec 2015
qPCR analysis revealed that BMP4 at a concentration of 50-100 ngml(-1) for a culture period of 14 days led to maximum induction of germ lineage genes like DAZL, VASA, PLZF (PGC-specific); SYCP3, MLH1, TNP1/2 and PRM2 (Meiotic genes); BOULE and TEKT1 (Spermatocyte markers); GDF9, ZP2 and 3 (Oocyte markers).
Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.
Chauhan et al., In Reprod Fertil Dev, Dec 2015
Quantitative polymerase chain reaction analysis revealed that 20%-40% CCM induced the highest expression of primordial germ cell-specific (deleted in Azoospermia- like (Dazl), dead (Asp-Glu-Ala-Asp) box polypeptide 4 (Vasa also known as DDX4) and promyelocytic leukemia zinc finger protein (Plzf)); meiotic (synaptonemal complex protein 3 (Sycp3), mutl homolog I (Mlh1), transition protein 1/2 (Tnp1/2) and protamine 2 (Prm2); spermatocyte-specific boule-like RNA binding protein (Boule) and tektin 1 (Tekt1)) and oocyte-specific growth differentiation factor 9 (Gdf9) and zona pellucida 2 /3 (Zp2/3)) genes over 8-14 days in culture.
Stable integration and expression of a cry1Ia gene conferring resistance to fall armywormand boll weevil in cotton plants.
Santos et al., Recife, Brazil. In Pest Manag Sci, Dec 2015
BACKGROUND: Boll weevil is a serious pest of cotton crop.
The Complexity of Posttranscriptional Small RNA Regulatory Networks Revealed by In Silico Analysis of Gossypium arboreum L. Leaf, Flower and Boll Small Regulatory RNAs.
Locy et al., Montgomery, United States. In Plos One, 2014
To understand the biological significance of these gene regulators in G. arboreum, a bioinformatics analysis was performed on G. arboreum small RNAs produced from G. arboreum leaf, flower, and boll tissues.
Epigenetic regulation of bovine spermatogenic cell-specific gene boule.
Li et al., Nanjing, China. In Plos One, 2014
Non-primate mammals have two deleted azoospermia (DAZ) family genes, DAZL and Boule; genes in this family encode RNA-binding proteins essential for male fertility in diverse animals.
DAZ Family Proteins, Key Players for Germ Cell Development.
Shen et al., Qingdao, China. In Int J Biol Sci, 2014
The family includes Boule (or Boll), Dazl (or Dazla) and DAZ genes.
Very small embryonic-like stem cells (VSELs) detected in azoospermic testicular biopsies of adult survivors of childhood cancer.
Bakshi et al., Mumbai, India. In Reprod Biol Endocrinol, 2014
Pluripotent transcripts Oct-4A, Nanog and Sox-2 were detected in azoospermic samples whereas marked reduction was observed in germ cell markers Oct-4 and Boule.
Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome.
Sandoval et al., Barcelona, Spain. In Plos One, 2014
Among the identified hypomethylated CpG-island associated genes, we confirmed the overexpression of three selected genes, BOLL, SYCP2 and NCRNA00221, in ICF compared to healthy controls, which are supposed to be expressed in germ line and silenced in somatic tissues.
The roles of DAZL in RNA biology and development.
Pantakani et al., Göttingen, Germany. In Wiley Interdiscip Rev Rna, 2014
The DAZ (Deleted in Azoospermia) family of proteins, which includes DAZ, DAZL, and BOULE, are germ cell-specific RNA-binding proteins that are implicated in translational regulation of several transcripts.
CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval.
Yogev et al., Tel Aviv-Yafo, Israel. In Fertil Steril, 2011
Assessing the expression of both CDY1 and BOULE by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue biopsies.
A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.
Xu et al., Chicago, United States. In Hum Mol Genet, 2010
Expression of key regulators of spermiogenesis was unaffected in Boule(-/-) mice, suggesting that Boule regulates germ-cell differentiation through a novel pathway.
Phenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population.
Yang et al., Chengdu, China. In J Androl, 2010
expression of spermatogenic phenotypes of partial AZFc deletions is independent of the variations in DAZL and BOULE in the Han population
Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A.
Lanska, United States. In Handb Clin Neurol, 2009
Early retinal photochemistry: In the 1870s, Boll found that light causes bleaching of the retinal pigment, and suggested that the outer segments of the rods contain a substance that conveys an impression of light to the brain by a photochemical process.
Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation.
Reijo Pera et al., Palo Alto, United States. In Nature, 2009
human DAZL (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related genes DAZ and BOULE (also called BOLL) promote later stages of meiosis and development of haploid gametes
New horizons for in vitro spermatogenesis? An update on novel three-dimensional culture systems as tools for meiotic and post-meiotic differentiation of testicular germ cells.
Wistuba et al., Münster, Germany. In Mol Hum Reprod, 2009
Boule)] obtained from immature mice pass through meiosis in vitro.
Posttranscriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis.
Cheng et al., Tainan City, Taiwan. In J Clin Endocrinol Metab, 2009
CDC25A is subject to translational control by BOLL, which is an evolutionarily conserved mechanism.
Role of the DAZ genes in male fertility.
Cooke et al., Edinburgh, United Kingdom. In Reprod Biomed Online, 2005
The DAZ family of genes (consisting of homologues of BOULE, DAZL and DAZ) encode highly conserved RNA-binding proteins that are essential for gametogenesis in metazoans.
Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule.
Wasserman et al., San Diego, United States. In Nat Cell Biol, 1999
Boule, a Drosophila orthologue of the vertebrate Dazl fertility factors, is a testis-specific regulator of meiotic entry and germline differentiation.
Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia.
Wasserman et al., Dallas, United States. In Nature, 1996
Here we describe the cloning and characterization of the Drosophila gene boule, which is a homologue of DAZ.
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