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CCCTC-binding factor

Boris, CTCFL
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Histone, OUT, V1a
Papers using Boris antibodies
The PhenX toolkit: get the most from your measures
Butte Atul J et al., In International Journal of Epidemiology, 2010
... We thank the Hewlett Packard Foundation for computer infrastructure and Alex Skrenchuk and Boris Oskotsky, PhD, of Stanford Biomedical Informatics Research (Stanford University ...
High sensitivity mapping of methylated cytosines
Rando Oliver, In PLoS Biology, 1993
... Immunization of rabbits with GST N-terminal CTCFL (1–229 aa) fusion protein was done in collaboration with Eurogentec (Seraing, Belgium) ...
Papers on Boris
Splitting methods for time integration of trajectories in combined electric and magnetic fields.
Ostermann et al., Innsbruck, Austria. In Phys Rev E Stat Nonlin Soft Matter Phys, Dec 2015
We present a second-order time integration method which preserves well the Poisson structure and compare it to commonly used algorithms, such as the Boris scheme.
Expression of the CTCFL Gene during Mouse Embryogenesis Causes Growth Retardation, Postnatal Lethality, and Dysregulation of the Transforming Growth Factor β Pathway.
McGrath et al., Antalya, Turkey. In Mol Cell Biol, Oct 2015
CTCFL, a paralog of CTCF, also known as BORIS (brother of regulator of imprinted sites), is a testis-expressed gene whose function is largely unknown.
Estimation of out-of-pocket costs of patients at the methadone maintenance therapy clinic in Malaysia.
Jafarian et al., Kuala Selangor, Malaysia. In Pak J Pharm Sci, Sep 2015
This survey utilizes the questionnaire by Boris ova & Goodman (2003) on the OOP, WTP and WTA.
Prohibiting juvenile access to tobacco: Violation rates, cigarette sales, and youth smoking.
Monnat et al., Las Vegas, United States. In Int J Drug Policy, Sep 2015
Some researchers claim that such policies have failed and ought to be abandoned (Craig & Boris, 2007; Etter, 2006; Glantz, 2002), while others insist that enforcement has indeed led to reduced tobacco use (DiFranza, 2011b; SAMHSA, 2011).
Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer.
Jarrard et al., Madison, United States. In Neoplasia, 2014
The chromatin regulator CTCF, its cofactor CHD8, and antagonistic paralogue BORIS have wide-ranging effects on gene regulation.
A Common Polymorphism within the IGF2 Imprinting Control Region Is Associated with Parent of Origin Specific Effects in Infantile Hemangiomas.
Narayan et al., New Haven, United States. In Plos One, 2014
We demonstrate that IGF2 expression in IH is strongly related to the expression of a cancer testes and suspected oncogene BORIS (paralog of CTCF), placing IH in the unique category of being the first known benign BORIS positive tumor.
Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells.
Benhattar et al., Lausanne, Switzerland. In Plos One, 2014
BORIS (Brother of Regulator of Imprinted Sites) or CTCFL (CTCF-like) is a DNA-binding protein that is expressed in normal tissues only in germ cells and is re-activated in tumors.
BORIS and CTCF are overexpressed in squamous intraepithelial lesions and cervical cancer.
Lazalde Medina et al., Durango, Mexico. In Genet Mol Res, 2014
We investigated the expression of Brother of Regulator of Imprinted Sites (BORIS) and CCCTC-binding factor (CTCF) in squamous intraepithelial lesions and cervical cancer.
Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions.
Lobanenkov et al., Rockville, United States. In Genome Biol, 2014
BACKGROUND: CTCF and BORIS (CTCFL), two paralogous mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutually exclusive manner in DNA binding and transcriptional regulation.
The endocrine quiz.
Nagesh et al., Karnāl, India. In Indian J Endocrinol Metab, 2014
Be it epic characters like Kumbhakarna and Bheema, fiction characters like Tintin or Orphan Annie, sportspersons like Gail Devers or heads of state like George Bush Sr and Boris Yeltsin, all have contributed to the melting pot of endocrine quizzing.
[On a contribution of Boris Balinsky to the comparative and ecological embryology of amphibians].
Desnitskiĭ, In Ontogenez, 2014
The outstanding embryologist Boris Ivanovich Balinsky (1905-1997) worked in the Soviet Union up to 1941 and in South Africa since 1949.
CTCF and BORIS in genome regulation and cancer.
Rasko et al., Australia. In Curr Opin Genet Dev, 2014
CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS.
Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer.
Kawakami et al., Tokyo, Japan. In Cancer Sci, 2012
BORIS may be a useful biomarker for prognostic diagnosis of ESCC patients and a potential target for treatment including by BORIS-specific immunotherapy and molecular target therapy.
Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma.
Giordano et al., Philadelphia, United States. In Cell Cycle, 2012
Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells.
BORIS in human cancers -- a review.
Martin-Kleiner, Zagreb, Croatia. In Eur J Cancer, 2012
Brother of the regulator of the imprinted site (BORIS) or CTCFL is an 11 zinc finger (ZF) protein, which is considered to be a new oncogene.
Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells.
Nir et al., Ramat Gan, Israel. In J Biol Chem, 2012
Transcription of the ferT gene in colon cancer cells was found to be driven by an intronic promoter residing in intron 10 of the fer gene and to be regulated by the Brother of the Regulator of Imprinted Sites (BORIS) transcription factor.
Genome-wide copy number profiling using a 100K SNP array reveals novel disease-related genes BORIS and TSHZ1 in juvenile angiofibroma.
Wendler et al., Homburg, Germany. In Int J Oncol, 2011
a significant up-regulation of BORIS (p<0.001) and TSHZ1 transcripts (p<0.05) for JAs compared to nasal mucosa.
Expression of the epigenetic factor BORIS (CTCFL) in the human genome.
Carrier et al., Loma Linda, United States. In J Transl Med, 2010
This review summarizes what is known about BORIS regarding its expression, structure, and function.
Single enzyme studies: a historical perspective.
Knight, United Kingdom. In Methods Mol Biol, 2010
In particular, I discuss the 1961 paper by Boris Rotman, which made inventive use of what now seems like primitive technology, and continues to be influential to this day.
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