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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Bone morphogenetic protein 7

BMP-7, bone morphogenetic protein-7, osteogenic protein-1, OP-1
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BMP7, CAN, BMP4, V1a, HAD
Papers on BMP-7
Bone healing in rabbit calvarial critical-sized defects filled with stem cells and growth factors combined with granular or solid scaffolds.
Sándor et al., Oulu, Finland. In Childs Nerv Syst, Feb 2016
This study aimed to assess the healing of rabbit calvarial critical-sized defects filled with osteogenic material, either with bioactive glass scaffolds or tricalcium phosphate granules in various combinations with adipose stem cells or bone marrow stem cells, BMP-2, BMP-7, or VEGF to enhance osteogenesis.
CD200 expression in human cultured bone marrow mesenchymal stem cells is induced by pro-osteogenic and pro-inflammatory cues.
Deschaseaux et al., Tours, France. In J Cell Mol Med, Feb 2016
In addition, osteogenic cues generated by bone morphogenetic protein 4 (BMP4) or BMP7 strongly induced CD200 expression.
Reduced Response of Human Meniscal Cells to Osteogenic Protein 1 during Osteoarthritis and Pro-inflammatory Stimulation.
Ferguson et al., Winston-Salem, United States. In Osteoarthritis Cartilage, Feb 2016
Osteogenic Protein 1 (OP1/BMP7) was evaluated for the ability to enhance extracellular matrix synthesis in healthy and OA meniscus cells.
Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells.
Takahashi et al., Nagasaki, Japan. In Invest Ophthalmol Vis Sci, Feb 2016
Connexin43 and aquaporin1 were expressed in both thin layers, and induced CE-like cells expressed ciliary marker genes, such as cyclinD2, zic1, tgfb2, aldh1a3, wfdc1, otx1, BMP4, and BMP7.
Therapeutic potential of regulatory cytokines that target B cells.
Yamamoto et al., Tokyo, Japan. In Int Immunol, Jan 2016
In contrast to TGF-β1, which induces extensive fibrosis, TGF-β3 and bone morphogenetic protein 6 (BMP-6)/BMP-7 induce non-scarring wound healing and counteract tissue fibrosis.
The missing effect of human recombinant Bone Morphogenetic Proteins BMP-2 and BMP-7 in surgical treatment of aseptic forearm nonunion.
Friederichs et al., Germany. In Injury, Dec 2015
Additional biological augmentation using BMP-2 or BMP-7 was performed in 24 patients.
Extracellular signaling molecules to promote fracture healing and bone regeneration.
Shaughnessy et al., East Lansing, United States. In Adv Drug Deliv Rev, Dec 2015
The first commercialized growth factors approved for bone regeneration, Bone Morphogenetic Protein 2 and 7 (BMP2 and BMP7), are direct inducers of osteoblast differentiation.
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
Van Cutsem et al., Barcelona, Spain. In Lancet Oncol, Aug 2015
We also measured the concentration of 15 proteins of interest-angiopoietin 2, interleukin 6, interleukin 8, placental growth factor, soluble TIE-1, soluble VEGFR1, VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metalloproteinase 2, and von Willebrand factor-in plasma samples from 611 patients.
Bone graft substitutes for spine fusion: A brief review.
El-Amin Iii et al., Springfield, United States. In World J Orthop, Aug 2015
Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins (recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion.
Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes.
Farmer et al., Boston, United States. In Cell, Feb 2015
Here, we report the identification of a BMP7-ROCK signaling axis regulating beige adipocyte formation via control of the G-actin-regulated transcriptional coactivator myocardin-related transcription factor A, MRTFA.
Biologic Agents for Periodontal Regeneration and Implant Site Development.
Wang et al., Ann Arbor, United States. In Biomed Res Int, 2014
It was the purpose of this comprehensive review to describe the origin and rationale, evidence, and the most current understanding of the following biologic agents: Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB), Enamel Matrix Derivate (EMD), Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2), Bone Morphogenic Proteins (BMPs, BMP-2 and BMP-7), Teriparatide PTH, and Growth Differential Factor-5 (GDF-5).
BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic Kidney Disease.
Moore et al., Saint Louis, United States. In Vitam Horm, 2014
The therapeutic potential of BMP-7 was first recognized nearly two decades ago with studies demonstrating its requirement for kidney development and ability to inhibit the pathogenesis of renal injury in models of CKD.
Osteogenesis induced by a bone forming peptide from the prodomain region of BMP-7.
Yoon et al., Kwangju, South Korea. In Biomaterials, 2012
analysis of osteogenesis induced by a bone forming peptide from the prodomain region of BMP-7
Gremlin-mediated decrease in bone morphogenetic protein signaling promotes aristolochic acid-induced epithelial-to-mesenchymal transition (EMT) in HK-2 cells.
Huang et al., Chongqing, China. In Toxicology, 2012
A decrease in BMP-7 expression results from knockdown of markers of epithelial-to-mesenchymal transition by gremlin protein.
Μolecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance.
Jiang et al., Beijing, China. In Int J Mol Med, 2012
BMP7 has an important role in controlling lung cancer cell motility and invasiveness.
Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway.
Tseng et al., Boston, United States. In Faseb J, 2012
results underscore the importance of BMP7 in regulating both food intake and energy expenditure, and suggest new therapeutic approaches for obesity and its comorbidities
TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.
Settleman et al., United States. In Cell, 2012
In APC mutant/KRAS-dependent cells, KRAS stimulates BMP-7 secretion and BMP signaling, leading to TAK1 activation and enhancement of Wnt-dependent transcription.
Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.
Graf et al., Greece. In Plos One, 2011
Data show that Bmp7 regulates Ngn2 steady-state transcript levels in the E14.5 cortex.
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.
Brown et al., Houston, United States. In Endocr Rev, 2011
Although bone morphogenetic protein (BMP) 4 is generally considered a protein that promotes the differentiation of white adipocytes, BMP7 has emerged as a selective regulator of brown adipogenesis.
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Kahn et al., Boston, United States. In Nature, 2008
expression of BMP7 in mice results in a significant increase in brown, but not white, fat mass and leads to an increase in energy expenditure and a reduction in weight gain
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