Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Ottawa, Canada. In Am J Clin Nutr, Jun 2015
Vitamin status was associated mainly with SNPs in genes directly involved in vitamin absorption/uptake (CUBN, CD320), transport (TCN1, TCN2), or metabolism (BHMT2, CBS, MTHFR, MUT, SHMT1).
Genome-wide expression in visceral adipose tissue from obese prepubertal children.
Armilla, Spain. In Int J Mol Sci, 2014
As validated by qPCR, expression was upregulated in genes involved in lipid and amino acid metabolism (CES1, NPRR3 and BHMT2), oxidative stress and extracellular matrix regulation (TNMD and NQO1), adipogenesis (CRYAB and AFF1) and inflammation (ANXA1); by contrast, only CALCRL gene expression was confirmed to be downregulated.
Genetic variants associated with protein C levels.
Utrecht, Netherlands. In J Thromb Haemost, 2013
Next-generation sequencing of 113 candidate genes under the linkage peak revealed four SNPs in BHMT2, ACOT12, SSBP2 and XRCC4, which significantly increased PC levels in our thrombophilic family, but not in LETS.
Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk.
Winston-Salem, United States. In Neurology, 2011
METHODS: Eighty-six SNPs in 9 candidate genes (BHMT1, BHMT2, CBS, CTH, MTHFR, MTR, MTRR, TCN1, and TCN2) were genotyped in 2,206 subjects (83% European American).
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Poland. In Eur J Obstet Gynecol Reprod Biol, 2011
STUDY DESIGN: We studied 16 SNPs in 12 folate and choline metabolism genes, including BHMT (rs7356530 and rs3733890), BHMT2 (rs625879), CBS (844ins68), CHDH (rs893363 and rs2289205), CHKA (rs7928739), MTHFD1 (rs2236225), MTHFR (rs1801133), MTR (rs1805087), MTRR (rs1801394), PCYT1A (rs712012 and rs7639752), PEMT (rs4244593 and rs4646406) and TCN (rs1801198) in one hundred and sixty-three infertile women with minimal endometriosis and one hundred and fifty fertile women.
Folate pathway and nonsyndromic cleft lip and palate.
Miami, United States. In Birth Defects Res A Clin Mol Teratol, 2011
RESULTS: Evidence for a risk association between NSCLP and SNPs in NOS3 and TYMS was detected in the non-Hispanic white group, whereas associations with MTR, BHMT2, MTHFS, and SLC19A1 were detected in the Hispanic group.