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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Betaine--homocysteine S-methyltransferase 2

BHMT2, betaine-homocysteine methyltransferase 2, Betaine-homocysteine S-methyltransferase-2
Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: BHMT, methylenetetrahydrofolate reductase, methionine synthase, ACID, SRA
Papers on BHMT2
A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects.
Hobbs et al., Bloomington, United States. In Ann Hum Genet, Jan 2016
These three variants are located within genes BHMT2, GSTP1, and GPX3, respectively.
Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.
Ulrich et al., New Brunswick, United States. In Cancer, Nov 2015
Significant interactions between nutrient biomarkers and candidate polymorphisms were observed for 1) plasma/RBC folate and folate hydrolase 1 (FOLH1), paraoxonase 1 (PON1), transcobalamin II (TCN2), DNMT1, and DNMT3B; 2) plasma PLP and TYMS TS3; 3) plasma B12 and betaine-homocysteine S-methyltransferase 2 (BHMT2); and 4) homocysteine and methylenetetrahydrofolate reductase (MTHFR) and alanyl-transfer RNA synthetase (AARS).
Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.
National Birth Defects Prevention Study et al., Palo Alto, United States. In Am J Med Genet A, Jun 2015
In addition, multiple SNPs in betaine-homocysteine methyltransferase (BHMT and BHMT2) were also identified to be associated with the occurrence of OHDs through significant main infant genetic effects and interaction effects with maternal use of folic acid supplements.
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
MacFarlane et al., Ottawa, Canada. In Am J Clin Nutr, Jun 2015
Vitamin status was associated mainly with SNPs in genes directly involved in vitamin absorption/uptake (CUBN, CD320), transport (TCN1, TCN2), or metabolism (BHMT2, CBS, MTHFR, MUT, SHMT1).
Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.
Schook et al., Urbana, United States. In Plos One, 2014
Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl donor substrates.
Genome-wide expression in visceral adipose tissue from obese prepubertal children.
Gil et al., Armilla, Spain. In Int J Mol Sci, 2014
As validated by qPCR, expression was upregulated in genes involved in lipid and amino acid metabolism (CES1, NPRR3 and BHMT2), oxidative stress and extracellular matrix regulation (TNMD and NQO1), adipogenesis (CRYAB and AFF1) and inflammation (ANXA1); by contrast, only CALCRL gene expression was confirmed to be downregulated.
Genetic variants associated with protein C levels.
Bovill et al., Utrecht, Netherlands. In J Thromb Haemost, 2013
Next-generation sequencing of 113 candidate genes under the linkage peak revealed four SNPs in BHMT2, ACOT12, SSBP2 and XRCC4, which significantly increased PC levels in our thrombophilic family, but not in LETS.
Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2.
Jiráček et al., Praha, Czech Republic. In J Med Chem, 2012
Betaine-homocysteine S-methyltransferase 2 (BHMT-2) catalyzes the transfer of a methyl group from S-methylmethionine to l-homocysteine, yielding two molecules of l-methionine.
Polymorphic variants of genes involved in homocysteine metabolism in celiac disease.
Jagodzinski et al., Warsaw, Poland. In Mol Biol Rep, 2012
A set of 10 gene polymorphisms (MTHFR rs1801133, MTR rs1805087, MTHFD1 rs2236225, MTRR rs1801394, CBS 844ins68, BHMT1 rs7356530 and rs3733890, BHMT2 rs526264 and rs625879, and TCN2 rs1801198) was tested in 134 patients with CD and 160 matched healthy controls.
A splicing variant leads to complete loss of function of betaine-homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma.
Forges et al., Nancy, France. In Int J Biochem Cell Biol, 2012
We aimed to investigate BHMT, BHMT2, and MTR expression in HepG2 cells and human hepatocarcinoma tissues.
Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk.
Sale et al., Winston-Salem, United States. In Neurology, 2011
METHODS: Eighty-six SNPs in 9 candidate genes (BHMT1, BHMT2, CBS, CTH, MTHFR, MTR, MTRR, TCN1, and TCN2) were genotyped in 2,206 subjects (83% European American).
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Jagodziński et al., Poland. In Eur J Obstet Gynecol Reprod Biol, 2011
STUDY DESIGN: We studied 16 SNPs in 12 folate and choline metabolism genes, including BHMT (rs7356530 and rs3733890), BHMT2 (rs625879), CBS (844ins68), CHDH (rs893363 and rs2289205), CHKA (rs7928739), MTHFD1 (rs2236225), MTHFR (rs1801133), MTR (rs1805087), MTRR (rs1801394), PCYT1A (rs712012 and rs7639752), PEMT (rs4244593 and rs4646406) and TCN (rs1801198) in one hundred and sixty-three infertile women with minimal endometriosis and one hundred and fifty fertile women.
New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate.
Scapoli et al., Bologna, Italy. In Eur J Oral Sci, 2011
No significant level of association was found with cleft lip with or without cleft palate and BHMT2 variants.
Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes.
Schook et al., Urbana, United States. In Gene, 2011
Betaine homocysteine methyltransferase (BHMT) and BHMT-2 enzymes methylate homocysteine to form methionine using betaine and S-methylmethionine, respectively.
Folate pathway and nonsyndromic cleft lip and palate.
Hecht et al., Miami, United States. In Birth Defects Res A Clin Mol Teratol, 2011
RESULTS: Evidence for a risk association between NSCLP and SNPs in NOS3 and TYMS was detected in the non-Hispanic white group, whereas associations with MTR, BHMT2, MTHFS, and SLC19A1 were detected in the Hispanic group.
Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.
Jagodzinski et al., Poznań, Poland. In Eur J Oral Sci, 2010
gene-gene interaction analysis revealed a significant epistatic interaction of BHMT2 (rs673752), PEMT (rs12325817), and PCYT1A (rs712012) with maternal NCL/P susceptibility.
Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization.
Weinshilboum et al., Rochester, United States. In Mol Genet Metab, 2008
Common genetic variation in BHMT and BHMT2 and functionally characterized BHMT SNPs.
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.
Garrow et al., Urbana, United States. In J Biol Chem, 2008
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.
Rozen et al., Montréal, Canada. In Atherosclerosis, 2003
Hyperhomocysteinemia, a risk factor for coronary diseases, can be caused by genetic mutations in BHMT2 metabolism.
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