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Transforming growth factor, beta receptor III

Betaglycan, TGFBR3, TGF-beta receptor type III
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: TGF-beta, CAN, SFRP1, V1a, TGF-beta type I receptor
Papers on Betaglycan
Significance of TGFBR3 allelic loss in the deregulation of TGFβ signaling in primary human endometrial carcinomas.
Krajewska et al., Łódź, Poland. In Oncol Rep, Feb 2016
Downregulation of betaglycan (β-glycan) [transforming growth factor β receptor type III (TGFβR3)], which belongs to co-receptors of the TGFβ pathway, occurs in a broad spectrum of primary human malignancies.
BMP2 rescues deficient cell migration in Tgfbr3(-/-) epicardial cells and requires Src kinase.
Camenisch et al., Tucson, United States. In Cell Adh Migr, Jan 2016
Utilizing a primary epicardial cell line derived from Tgfbr3(+/+) and Tgfbr3(-/-) mouse embryos, we show that Tgfbr3(-/-) epicardial cells are deficient in BMP2 mRNA expression.
A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore.
Vithana et al., Singapore, Singapore. In Ophthalmology, Dec 2015
Single nucleotide polymorphisms (SNPs) and their proxies from 10 POAG-associated loci (CAV1-CAV2, CDKN2B-AS1, SIX1-SIX6, an intergenic region on chromosome 8q22, ABCA1, GAS7, AFAP1, GMDS, PMM2, and TGFBR3-CDC7) identified from genome-wide association studies were tested for association with VF progression using logistic regression with an additive genetic model adjusting for age, gender, average intraocular pressure (IOP), central corneal thickness (CCT), and baseline vertical cup-to-disc ratio (VCDR).
Pleomorphic hyalinizing angiectatic tumor revisited: all tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity.
Michal et al., Plzeň, Czech Republic. In Ann Diagn Pathol, Nov 2015
Recently described TGFBR3 and MGEA5 gene rearrangements in these tumors have confirmed the long-hypothesized link between PHAT and another soft tissue entity, the myxoinflammatory fibroblastic sarcoma (MIFS).
Exploring evidence of positive selection reveals genetic basis of meat quality traits in Berkshire pigs through whole genome sequencing.
Lee et al., Seoul, South Korea. In Bmc Genet, 2014
We identified several associated genes related to lipid metabolism, intramuscular fatty acid deposition, and muscle fiber type which attribute to pork quality (TG, FABP1, AKIRIN2, GLP2R, TGFBR3, JPH3, ICAM2, and ERN1) by applying between population statistical tests (XP-EHH and XP-CLR).
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Chalam et al., Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) at different loci including CAV1/CAV2, TMCO1, CDKN2B-AS1, CDC7-TGFBR3, SIX1/SIX6, GAS7 and ATOH7 to be associated with POAG and its related quantitative traits (endophenotypes).
Myxoinflammatory fibroblastic sarcoma: morphologic and genetic updates.
Thway et al., London, United Kingdom. In Arch Pathol Lab Med, 2014
Distinct and reproducible genetic abnormalities identified in MIFS are translocation t(1;10)(p22:q24), with rearrangements of the TGFBR3 and MGEA5 genes associated with increased levels of FGF8, and formation of marker/ring chromosome 3, with amplification of the VGLL3 locus.
Understanding tissue context influences on intratumour heterogeneity.
Weaver et al., Boston, United States. In Nat Cell Biol, 2014
Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3-JUND signalling circuit in an extracellular-matrix-dependent manner.
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.
Janes et al., Charlottesville, United States. In Nat Cell Biol, 2014
The first contains multiple TGF-β-related genes including TGFBR3, whereas the second contains JUND and the basal-like marker KRT5.
HMGA2 functions as a competing endogenous RNA to promote lung cancer progression.
Downward et al., Stanford, United States. In Nature, 2014
Integrated analysis of miRNA target prediction algorithms and metastatic lung cancer gene expression data reveals the TGF-β co-receptor Tgfbr3 (ref.
BMP-7 counteracting TGF-beta1 activities in organ fibrosis.
Meurer et al., Aachen, Germany. In Front Biosci, 2012
CCN proteins), Endoglin, Betaglycan, BAMBI and the members of the repulsive guidance molecule family that modulate cellular proliferation, migration, adhesion and extracellular matrix production.
The genetics of Behçet's disease in a Chinese population.
Yang et al., Chongqing, China. In Front Med, 2012
Significant associations were found between Behçet's disease and STAT4, IL23R, CD40, CCR1/CCR3, STAT3, MCP-1, TGFBR3, FCRL3, SUMO4, UBAC2.
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.
Kiel et al., Boston, United States. In J Clin Endocrinol Metab, 2012
Among 59 novel BMD GWAS loci that have not been reported by previous candidate gene association studies, some have been shown to be involved in key biological pathways involving the skeleton, particularly Wnt signaling (AXIN1, LRP5, CTNNB1, DKK1, FOXC2, HOXC6, LRP4, MEF2C, PTHLH, RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, PTHLH, RUNX2, SOX6, SOX9, SPP1, SP7), mesenchymal-stem-cell differentiation (FAM3C, MEF2C, RUNX2, SOX4, SOX9, SP7), osteoclast differentiation (JAG1, RUNX2), and TGF-signaling (FOXL1, SPTBN1, TGFBR3).
BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion.
Barnett et al., Nashville, United States. In Cell Signal, 2012
the relative roles of TGFbetaR3-dependent and -independent signaling in the actions of BMP2 on epicardial cell behavior and demonstrate the critical role of TGFbetaR3 in mediating BMP2-stimulated invasion.
Association analysis of TGFBR3 gene with Vogt-Koyanagi-Harada disease and Behcet's disease in the Chinese Han population.
Kijlstra et al., Chongqing, China. In Curr Eye Res, 2012
rs1805110 CC genotype in TGFBR3 is probably associated with the protection from BD. The tested two TGFBR3 SNPs are not associated with VKH disease.
A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation.
Gupta et al., Copenhagen, Denmark. In J Med Genet, 2012
Markers located in the region of TGFBR3 and BMP7 showed association with all testicular dysgenesis syndrome phenotypes in both the discovery and replication cohorts
TGFBR3 variation is not a common cause of Marfan-like syndrome and Loeys-Dietz-like syndrome.
Arslan-Kirchner et al., Hannover, Germany. In J Negat Results Biomed, 2011
Variations in TGFBR3 gene appear not to be associated with Marfan syndrome or related phenotype.
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.
Granville et al., Vancouver, Canada. In Plos One, 2011
Data show that granzyme B (GrB) liberated TGF-beta1 from substrates decorin, biglycan and betaglycan.
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling.
Vale et al., Los Angeles, United States. In Nature, 2000
Here we show that the type III TGF-beta receptor, betaglycan, can function as an inhibin co-receptor with ActRII.
Betaglycan presents ligand to the TGF beta signaling receptor.
Massagué et al., New York City, United States. In Cell, 1993
This limitation is overcome by the action of betaglycan (TGF beta type III receptor), a separate TGF beta-binding membrane protein of previously unknown function.
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