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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


betacellulin, BTC
The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Epidermal Growth Factor, amphiregulin, EGFR, Insulin, CAN
Papers using betacellulin antibodies
Papers on betacellulin
Different EGF Receptor Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Protein.
Pike et al., Washington, D.C., United States. In J Biol Chem, Feb 2016
Ensemble clustering of the overall response to the different growth factors suggests that these EGF receptor ligands fall into two major groups: i) EGF, AREG and EPR; and ii) BTC, TGFα, and EPG.
Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers.
Serra et al., Toronto, Canada. In J Clin Pathol, Feb 2016
AIMS: To investigate the predictive and prognostic values of DNA repair genes excision repair cross-complementation group 1 (ERCC1) and X-ray repair cross-complementing group 1 (XRCC1) in tumour samples from patients with a diagnosis of biliary tract cancer (BTC).
A smart approach for in situ one step encapsulation and controlled delivery of chemotherapeutic drug using metal organic framework-drug composite in aqueous medium.
Adhikari et al., Indore, India. In Chemphyschem, Feb 2016
We found that drug release rateis higher for Zn-BTC-Dox composite than for Fe-BTC-Dox composite.This is attributed to the stronger binding betweenDOX and Fe-BTC than that between DOX and Zn-BTC.
Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells.
Nagano et al., Tokyo, Japan. In Biochem Biophys Res Commun, Feb 2016
ErbB4/HER4, which contains a ligand-binding extracellular region, is activated by several ligands, including neuregulins (NRGs), heparin-binding EGF-like growth factor, betacellulin and epiregulin.
Diagnostic significance of elevated expression of HBME-1 in papillary thyroid carcinoma.
Chen et al., Xi'an, China. In Tumour Biol, Feb 2016
Specimens from 96 patients with PTC and 110 patients with BTC were reviewed.
A Histone Deacetylase Inhibitor Suppresses Epithelial-Mesenchymal Transition and Attenuates Chemoresistance in Biliary Tract Cancer.
Mori et al., Suita, Japan. In Plos One, Dec 2015
In biliary tract cancer (BTC), EMT is induced by transforming growth factor-beta 1 (TGF-β1).
New genomic landscapes and therapeutic targets for biliary tract cancers.
Scarpa et al., Verona, Italy. In Front Biosci, Dec 2015
BTC-specific alterations include disorders of major regulators of cell cycle and chromatin remodeling processes, as well as deregulation of the mTOR-, TGF-beta/Smad- and receptor tyrosine kinases signaling.
Genomic spectra of biliary tract cancer.
Shibata et al., Tokyo, Japan. In Nat Genet, Sep 2015
The incidence of biliary tract cancer (BTC), including intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinoma and gallbladder cancer, has increased globally; however, no effective targeted molecular therapies have been approved at the present time.
The role of polycomb repressive complexes in biliary tract cancer.
Kiesslich et al., Salzburg, Austria. In Expert Opin Ther Targets, Mar 2015
Biliary tract cancer (BTC) is a rare malignancy associated with high chemoresistance and poor clinical outcome.
Biomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer.
Swain et al., Barcelona, Spain. In J Clin Oncol, 2014
PATIENTS AND METHODS: Mandatory tumor and serum samples were collected (N = 808; 58% to 99.8% were assessable), and amphiregulin, betacellulin, epidermal growth factor (EGF), transforming growth factor alpha, EGF receptor, HER2, HER3, insulin-like growth factor 1 receptor, PTEN, phosphorylated AKT, PIK3CA, CMYC, serum HER2 extracellular domain (sHER2), and FCγR were assessed using appropriate assays.
The ABC of BTC: structural properties and biological roles of betacellulin.
Schneider et al., München, Germany. In Semin Cell Dev Biol, 2014
Betacellulin was initially detected as a growth-promoting factor in the conditioned medium of a mouse pancreatic β-cell tumor cell line.
Recent developments in β-cell differentiation of pluripotent stem cells induced by small and large molecules.
Higuchi et al., Kuala Selangor, Malaysia. In Int J Mol Sci, 2013
activin A, betacellulin, bone morphogentic protein (BMP4), epidermal growth factor (EGF), fibroblast growth factor (FGF), keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), noggin, transforming growth factor (TGF-α), and WNT3A) are thought to contribute from the initial stages of definitive endoderm formation to the final stages of maturation of functional endocrine cells.
New and emerging treatment options for biliary tract cancer.
Hezel et al., Rochester, United States. In Onco Targets Ther, 2012
Biliary tract cancer (BTC) is a group of relatively rare tumors with a poor prognosis.
Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis.
Lovell-Badge et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2012
BTC induces expansion of neural stem cells and neuroblasts, and promotes neurogenesis in the olfactory bulb and dentate gyrus.
Regulation of retinal vascular permeability by betacellulin.
Anand-Apte et al., Cleveland, United States. In Adv Exp Med Biol, 2011
BTC has properties of increasing retinal vascular leakage that could contribute to the development of diabetic retinopathy.
Betacellulin overexpression in mesenchymal stem cells induces insulin secretion in vitro and ameliorates streptozotocin-induced hyperglycemia in rats.
Cirne-Lima et al., Porto Alegre, Brazil. In Stem Cells Dev, 2011
BTC overexpression enhances glucose-induced insulin secretion in Mesenchyma Stem Cells
Betacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors.
Jun et al., Inch'ŏn, South Korea. In Plos One, 2010
Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors
Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth.
Dempsey et al., Ann Arbor, United States. In J Cell Sci, 2010
Data suggest a novel receptor-independent role for betacellulin intracellular-domain fragment signaling due to its ability to inhibit cell growth in vitro.
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.
Chan et al., Houston, United States. In Nat Med, 2003
The diabetes of STZ mice was partially reversed by HDAD-mediated transfer of NeuroD (Neurod), a factor downstream of Ipf1, and completely reversed by a combination of Neurod and betacellulin (Btc), without producing hepatitis.
Betacellulin: a mitogen from pancreatic beta cell tumors.
Folkman et al., Boston, United States. In Science, 1993
Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors.
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