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Mannosidase, beta A, lysosomal

This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, lacZ, HAD, Endo, fibrillin-1
Papers on beta-Mannosidase
High-level expression and characterization of a thermophilic β-mannanase from Aspergillus niger in Pichia pastoris.
Ma et al., Wuhan, China. In Biotechnol Lett, Sep 2015
OBJECTIVES: A novel, high-level expression, thermostable mannan endo-1,4-beta-mannosidase is urgently needed for industrial applications.
Isolation and characterization of novel multifunctional recombinant family 26 glycoside hydrolase from mehsani buffalo rumen metagenome.
Joshi et al., Ānand, India. In Biotechnol Appl Biochem, Mar 2015
2_1_33B encoded mannan endo-1, 4-beta-mannosidase.
Quantitative iTRAQ secretome analysis of Aspergillus niger reveals novel hydrolytic enzymes.
Sze et al., Singapore, Singapore. In J Proteome Res, 2010
The enzymes have potential application in lignocellulosic biomass hydrolysis for biofuel production, for example, the cellulolytic and hemicellulolytic enzymes glucan 1,4-alpha-glucosidase, alpha-glucosidase C, endoglucanase, alpha l-arabinofuranosidase, beta-mannosidase, glycosyl hydrolase; proteases such as tripeptidyl-peptidase, aspergillopepsin, and other enzymes including cytochrome c oxidase, cytochrome c oxidase, glucose oxidase were highly expressed in A. niger and its mutant secretion.
Comparative analyses of two thermophilic enzymes exhibiting both beta-1,4 mannosidic and beta-1,4 glucosidic cleavage activities from Caldanaerobius polysaccharolyticus.
Cann et al., Urbana, United States. In J Bacteriol, 2010
The hydrolysis of polysaccharides containing mannan requires endo-1,4-beta-mannanase and 1,4-beta-mannosidase activities.
Production of ethanol and feed by high dry matter hydrolysis and fermentation of palm kernel press cake.
Ernst et al., Frederiksberg, Denmark. In Appl Biochem Biotechnol, 2010
Using a combination of mannanase, beta-mannosidase, and cellulases, it was possible without any pretreatment to hydrolyze PKC at solid concentrations of 35% dry matter with mannose yields up to 88% of theoretical.
Transcriptional regulation and molecular characterization of the manA gene encoding the biofilm dispersing enzyme mannan endo-1,4-beta-mannosidase in Xanthomonas campestris.
Tseng et al., Taiwan. In J Agric Food Chem, 2010
Addition of DSF or Xcc extracellular protein containing partially purified mannanase (EC,
Pyridylamination as a means of analyzing complex sugar chains.
Hase, Toyonaka, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2009
This novel approach was applied and some of the results are described: i) a glucosyl-serine type sugar chain found in blood coagulation factors; ii) discovery of endo-beta-mannosidase (EC
Efficient recombinant expression and secretion of a thermostable GH26 mannan endo-1,4-beta-mannosidase from Bacillus licheniformis in Escherichia coli.
Yamabhai et al., Nakhon Ratchasima, Thailand. In Microb Cell Fact, 2009
The Mannan endo-1,4-beta-mannosidase or 1,4-beta-D-mannanase (EC,
A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant.
Levade et al., Toulouse, France. In Bmc Med Genet, 2008
The present analysis of the c.1922G>A MANBA mutation underlines the lack of genotype-phenotype correlation in beta-mannosidosis
Cloning, expression in Pichia pastoris, and characterization of a thermostable GH5 mannan endo-1,4-beta-mannosidase from Aspergillus niger BK01.
Yamabhai et al., Nakhon Ratchasima, Thailand. In Microb Cell Fact, 2008
Biodegradation of beta-mannans by the action of thermostable mannan endo-1,4-beta-mannosidase offers significant technical advantages in biotechnological industrial applications, i.e. delignification of kraft pulps or the pretreatment of lignocellulosic biomass rich in mannan for the production of second generation biofuels, as well as for applications in oil and gas well stimulation, extraction of vegetable oils and coffee beans, and the production of value-added products such as prebiotic manno-oligosaccharides (MOS).
An overview of mannan structure and mannan-degrading enzyme systems.
Filho et al., Brasília, Brazil. In Appl Microbiol Biotechnol, 2008
The main-chain mannan-degrading enzymes include beta-mannanase, beta-glucosidase, and beta-mannosidase.
MANBA polymorphism was related to increased risk of colorectal cancer in Swedish but not in Chinese populations.
Sun et al., Linköping, Sweden. In Acta Oncol, 2007
The MANBA genotypes for a polymorphic CA repeat were related to colorectal cancer risk in a Swedish population but not a Chinese one. In the Swedish population, individuals with < 22 CAs/< 22 CAs had a significantly increased risk for CRC.
Angiokeratoma corporis diffusum in human beta-mannosidosis: Report of a new case and a novel mutation.
Zlotogorski et al., Jerusalem, Israel. In J Am Acad Dermatol, 2007
So far, mutational analysis has been performed in only seven families and revealed 11 mutations in the MANBA gene which encodes the enzyme beta-mannosidase.
Human beta-mannosidase deficiency associated with peripheral neuropathy.
Salvayre et al., Toulouse, France. In Ann Neurol, 1994
We present a further case in a black African 14-year-old boy with severely deficient beta-mannosidase activity, bilateral thenar and hypothenar amyotrophy, electrophysiologically demonstrable demyelinating peripheral neuropathy, and cytoplasmic vacuolation of skin fibroblasts and lymphoid cells.
Mammalian beta-D-mannosidase and beta-mannosidosis.
Ricard et al., Paris, France. In Biochimie, 1992
Our own results concerning human enzyme (from kidney and urine, seminal plasma and blood cells) suggest that, apart from the case of the inherited disease, beta-mannosidase may become a useful tool in other pathologies.
Purification and properties of a beta-mannosidase from shrimp (Penaeus japonicus) hepatopancreas.
Yang et al., Taipei, Taiwan. In Comp Biochem Physiol B, 1990
A beta-mannosidase was purified ca 720-fold to homogeneity from Penaeus japonicus, with a final spec.
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