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Coatomer protein complex, subunit beta 1

beta-COP, CopB, Replication Protein C
This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CopA, ACID, COPI, HAD, CIs
Papers on beta-COP
The copYAZ Operon Functions in Copper Efflux, Biofilm Formation, Genetic Transformation, and Stress Tolerance in Streptococcus mutans.
Cvitkovitch et al., Toronto, Canada. In J Bacteriol, Sep 2015
Most Gram-positive bacteria utilize the copYABZ operon for copper homeostasis, where copA and copB encode copper-transporting P-type ATPases, whereas copY and copZ regulate the expression of the cop operon.
Copper homeostasis-related genes in three separate transcriptional units regulated by CsoR in Corynebacterium glutamicum.
Inui et al., Kyoto, Japan. In Appl Microbiol Biotechnol, Apr 2015
In Corynebacterium glutamicum R, CsoR acts as a transcriptional repressor not only of the cognate copA-csoR operon but also of the copZ1-copB-cgR_0126 operon.
CopM is a novel copper-binding protein involved in copper resistance in Synechocystis sp. PCC 6803.
Florencio et al., Sevilla, Spain. In Microbiologyopen, Feb 2015
Mutants lacking copM showed a sensitive copper phenotype similar to mutants affected in copB, but lower than mutants of the two-component system CopRS, suggesting that CopBAC and CopM constitute two independent resistance mechanisms.
Coupling between the basic replicon and the Kis-Kid maintenance system of plasmid R1: modulation by Kis antitoxin levels and involvement in control of plasmid replication.
Díaz-Orejas et al., Madrid, Spain. In Toxins (basel), Feb 2015
kis-kid, the auxiliary maintenance system of plasmid R1 and copB, the auxiliary copy number control gene of this plasmid, contribute to increase plasmid replication efficiency in cells with lower than average copy number.
Chlamydia Outer Protein (Cop) B from Chlamydia pneumoniae possesses characteristic features of a type III secretion (T3S) translocator protein.
Mahony et al., Hamilton, Canada. In Bmc Microbiol, 2014
CopB is a predicted hydrophobic translocator protein within the chlamydial T3SS.
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Hirotsune et al., Ōsaka, Japan. In Nat Med, 2009
Here we show that inhibition or knockdown of calpains protects LIS1 from proteolysis, resulting in the augmentation of LIS1 amounts in Lis1(+/-) mouse embryonic fibroblast cells and rescue of the aberrant distribution of cytoplasmic dynein, mitochondria and beta-COP-positive vesicles.
Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.
Dobson et al., Worcester, United States. In Am J Physiol Heart Circ Physiol, 2009
A(1)R stimulation of the heart is associated with PLC-initiated PKC-epsilon translocation and association with RACK2
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function.
Collins et al., Ithaca, United States. In Bmc Cell Biol, 2007
Together, these results indicate an essential function for the predicted betaCOP appendage and suggest that both COPI appendages perform a biologically active regulatory role with a structure related to adaptin-family appendage domains.
Novel cargo-binding site in the beta and delta subunits of coatomer.
Schwappach et al., Heidelberg, Germany. In J Cell Biol, 2007
Two highly conserved stretches--in the beta- and delta-COPI subunits--are required to maintain Pmp2GFP reporters exposing R-based signals in the endoplasmic reticulum.
Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA.
Wei et al., Minneapolis, United States. In Proc Natl Acad Sci U S A, 2007
provides evidence for a microtubule-dependent, active axonal kappa opioid receptor mRNA-transport process that involves Copb1 and can stimulate localized translation
Plasmid R1--replication and its control.
Nordström, Uppsala, Sweden. In Plasmid, 2006
Plasmid R1 also has an ancillary control system, CopB, that derepresses the synthesis of repA-mRNA in cells that happen to contain lower than normal number of copies.
Copper chaperone cycling and degradation in the regulation of the cop operon of Enterococcus hirae.
Solioz et al., Bern, Switzerland. In Biometals, 2005
The cop operon of E. hirae consists of four genes that encode a repressor, CopY, a copper chaperone, CopZ, and two CPx-type copper ATPases, CopA and CopB.
Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes.
Walker et al., Boca Raton, United States. In J Cell Sci, 2004
RACK2 plays a role in epsilon-PKC anchoring in cardiac myofilaments.
Copper homeostasis in Enterococcus hirae.
Stoyanov et al., Bern, Switzerland. In Fems Microbiol Rev, 2003
It consists of four genes that encode a repressor, CopY, a copper chaperone, CopZ, and two CPx-type copper ATPases, CopA and CopB.
Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.
Goldstein et al., New Haven, United States. In Cell, 2002
Here, KCNK3 potassium channels are shown to bear two cytoplasmic trafficking motifs: an N-terminal dibasic site that binds beta-COP to hold channels in ER and a C-terminal "release" site that binds the ubiquitous intracellular regulator 14-3-3beta on a nonclassical motif in a phosphorylation-dependent fashion to suppress beta-COP binding and allow forward transport.
Vaccines for Moraxella catarrhalis.
McMichael, United States. In Vaccine, 2001
This set includes the lactoferrin binding protein A (LbpA) and lactoferrin binding protein B (LbpB), the transferrin binding protein A (TbpA) and transferrin binding protein B (TbpB), the CD and E porins, and the Catarrhalis outer membrane protein B (CopB).
Progress toward the development of a vaccine to prevent Moraxella (Branhamella) catarrhalis infections.
McMichael, United States. In Microbes Infect, 2000
This review examines the more promising antigens, including the 200K protein, the hemagglutinins, the lactoferrin-binding proteins, the UspA proteins, the CopB protein, the transferrin-binding proteins, the CD protein, the E protein and lipooligosaccharide conjugates.
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes.
Trono et al., Genève, Switzerland. In Cell, 1999
A sequence encompassing a critical acidic dipeptide, located nearby but distinct from the AP-binding determinant of HIV-1 Nef, is responsible for beta-COP recruitment and for routing to lysosomes.
Cytoplasmic coat proteins involved in endosome function.
Mellman et al., New Haven, United States. In Cell, 1996
Since microinjection of antibodies to beta-COP inhibits the entry of enveloped viruses via the endocytic pathway, it is apparent that the recruitment of COP-I or COP-I-related proteins plays an important role in the function of endosomes in intact cells.
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone.
Malhotra et al., San Diego, United States. In Cell, 1993
In addition, like brefeldin A (BFA), IQ treatment prevents the association of beta-COP and ADP-ribosylation factor to the Golgi membranes; however, unlike BFA treatment, there is no retrograde transport of Golgi enzymes into ER.
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