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Tubulin, beta 3 class III

beta-4, TUBB3, Bhlhb4, H-20
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Actin, V1a
Papers using beta-4 antibodies
Papers on beta-4
A novel TUBB3 mutation in a sporadic patient with asymmetric cortical dysplasia.
Yamamoto et al., Kawaguchi, Japan. In Am J Med Genet A, Feb 2016
The beta-tubulin class III gene (TUBB3) was identified as a gene responsible for MCDs.
Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery.
Huisman et al., Maastricht, Netherlands. In Cytotechnology, Jan 2016
The cells expressed class III β-tubulin (TUBB3) and synapsin-1 after 3 weeks of neuronal differentiation.
A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis.
Yu et al., Guangzhou, China. In Dev Comp Immunol, Jan 2016
UNASSIGNED: Thymosin beta-4 (Tβ4) is a ubiquitous protein with multiple and diverse intracellular and extracellular functions in vertebrates.
Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin-microtubule interface.
Muto et al., Wako, Japan. In Nat Commun, Dec 2015
Mutations in human β3-tubulin (TUBB3) cause an ocular motility disorder termed congenital fibrosis of the extraocular muscles type 3 (CFEOM3).
Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
Kim et al., Ch'ŏnan, South Korea. In Plos One, Dec 2015
BACKGROUND: Recent reports suggest that thymosin beta-4 (Tβ4) is a key regulator for wound healing and anti-inflammation.
Mitochondrial dynamics and inherited peripheral nerve diseases.
Piscosquito et al., Milano, Italy. In Neurosci Lett, Jul 2015
Microtubules, neurofilaments, and chaperones such as heat shock proteins (HSPs) also have a fundamental role in mitochondrial transport and mutations in some of related encoding genes cause peripheral neuropathy (TUBB3, NEFL, HSPB1, HSPB8, HSPB3, DNAJB2).
Biomarkers for efficacy of adjuvant chemotherapy following complete resection in NSCLC stages I-IIIA.
Sørensen et al., Copenhagen, Denmark. In Eur Respir Rev, Jun 2015
A statistically significant prognostic impact was reported for: iNTR, TUBB3, RRM1, ERCC1, BRCA1, p53, MRP2, MSH2, TS, mucin, BAG-1, pERK1/2, pAkt-1, microRNA, TopIIA, 15-gene profile, 92-gene profile, 31-gene profile and 14-gene profile.
Mutations in α- and β-tubulin encoding genes: implications in brain malformations.
Borgatti et al., Lecco, Italy. In Brain Dev, Mar 2015
Different mutations in α/β-tubulin genes (TUBA1A, TUBA8, TUBB2A, TUBB4A, TUBB2B, TUBB3, and TUBB) might alter the dynamic properties and functions of microtubules in several ways, effecting a reduction in the number of functional tubulin heterodimers and causing alterations in GTP binding and disruptions of the binding of other proteins to microtubules (motor proteins and other microtubule interacting proteins).
Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I-III Non-Small Cell Lung Cancer.
Merlo et al., Genova, Italy. In Dis Markers, 2014
The following biomarkers were investigated using IHC and q RT-PCR: excision repair cross-complementation group 1 (ERCC1), breast cancer 1 (BRCA1), ribonucleotide reductase subunits M1 and M2 (RRM1 and RRM2), subunit p53R2, thymidylate synthase (TS), and class III beta-tubulin (TUBB3).
Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor.
García-Borrón et al., Murcia, Spain. In Plos One, 2014
Human MC1R has an inefficient poly(A) site allowing intergenic splicing with its downstream neighbour Tubulin-β-III (TUBB3).
[TUBB3 role in the response of tumor cells to epothilones and taxanes].
Rogalska et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
On the basis of the literature data it can be concluded that one reason for the ineffectiveness of taxane is the resistance growing in the case of overexpression of b-tubulin class III- (TUBB3).
Regulation of microtubule motors by tubulin isotypes and post-translational modifications.
Vale et al., San Francisco, United States. In Nat Cell Biol, 2014
Revealing the importance and specificity of PTMs, we show that kinesin-1 motility on neuronal β-tubulin (TUBB3) is increased by polyglutamylation and that robust kinesin-2 motility requires detyrosination of α-tubulin.
Brain malformations and mutations in α- and β-tubulin genes: a review of the literature and description of two new cases.
Borgatti et al., Lecco, Italy. In Dev Med Child Neurol, 2014
AIM: The aim of this study was to determine the frequency of mutations in tubulin genes (TUBB2B, TUBA1A, and TUBB3) in patients with malformations of cortical development (MCDs) of unknown origin.
Gender influences the class III and V β-tubulin ability to predict poor outcome in colorectal cancer.
Ferlini et al., Danbury, United States. In Clin Cancer Res, 2012
in colorectal cancer patients, there was a link between poor survival, the expression of TUBB3/TUBB6, and androgen receptor only in females
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression.
Santin et al., Brescia, Italy. In Gynecol Oncol, 2012
Higher levels of TUBB3 were detected in uterine carcinosarcoma (CS) cell lines and fresh frozen tissues when compared to ovarian CS and were associated with sensitivity to patupilone.
Overexpression of βIII-tubulin and survivin associated with drug resistance to docetaxel-based chemotherapy in advanced gastric cancer.
Chen et al., Wenzhou, China. In J Buon, 2012
Overexpression of betaIII-tubulin is associated with drug resistance to docetaxel-based chemotherapy in advanced gastric cancer.
Mutation in the AP4B1 gene cause hereditary spastic paraplegia type 47 (SPG47) .
Schöls et al., Tübingen, Germany. In Neurogenetics, 2012
Data suggest that AP4B1 mutations cause spastic paraplegia type 47 and should be considered in early onset spastic paraplegia with intellectual disability.
Expression of β-tubulin III and survivin in advance stage breast cancer correlates with chemotherapeutic effects of docetaxel.
Chen et al., Wenzhou, China. In Asian Pac J Cancer Prev, 2011
High beta III-tubulin expression is associated with drug resistance to docetaxel in patients with advanced breast cancer.
Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.
Engle et al., Boston, United States. In Cell, 2010
Work to define the TUBB3 syndromes establishes the requirement for a neuronal beta-tubulin isotype in axon guidance and normal brain development.
MicroTUB(B3)ules and brain development.
Tsai et al., Cambridge, United States. In Cell, 2010
Tischfield et al. (2010) now report that mutations in the tubulin-encoding gene TUBB3 have a striking impact on microtubule dynamics in neurons, resulting in a diverse set of disease symptoms.
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