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Defensin, beta 1

BDI, hBD-1, beta-defensin-1
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Defensin, hBD-2, HAD, AGE, CAN
Papers on BDI
The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders.
Fennig et al., Petah Tikva, Israel. In J Child Adolesc Psychopharmacol, Feb 2016
Clinical response was measured with several scales, including the Children's Depression Rating Scale-Revised (CDRS-R), the Beck Depression Inventory (BDI), and the Screen for Child Anxiety Related Emotional Disorders (SCARED) Results: The overall response rate was 56%.
Kinetic analysis and molecular modelling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.
Giannini et al., Parma, Italy. In Glycobiology, Feb 2016
In particular, docking solutions were obtained in which i) a single roneparstat molecule interacts with both heparin-binding domains (HBD) of heparanase or ii) two fragments of roneparstat interact with either HBD-1 or HBD-2, consistent with the possibility of different inhibitor:enzyme binding stoichiometries.
Depressive symptomatology and the influence of the behavioral avoidance and activation: A gender-specific investigation.
Blairy et al., Liège, Belgium. In J Affect Disord, Feb 2016
METHODS: This study's aim was two-fold: (1) to assess the presence of gender differences on the BDI-II; (2) to investigate the respective predictive value of behavioral avoidance and of behavioral activation on each depressive symptom assessed by the BDI-II depending on gender.
Systemic levels of human β-defensin 1 are elevated in patients with cirrhosis.
Ladas et al., Athens, Greece. In Ann Gastroenterol, Jan 2016
Human beta defensin-1 (hBD-1) is a member of the family of natural antimicrobial peptides produced by epithelial cells and participates in the mucosal defensive mechanisms that prevent BT.
Affective regulation in trichotillomania before and after self-help interventions.
Rufer et al., Zürich, Switzerland. In J Psychiatr Res, Jan 2016
Affective Regulation Scale (ARS), Massachusetts General Hospital Hair-Pulling Scale (MGH-HPS), and Beck Depression Inventory (BDI) scores were obtained at baseline, post-treatment (4 weeks), and follow-up (6 months).
Repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression in Parkinson disease: a meta-analysis of randomized controlled clinical trials.
Wang et al., Wenzhou, China. In Neurol Sci, Oct 2015
However, we found similar antidepressant efficacy between rTMS and SSRIs groups in terms of HRSD and BDI score (p = 0.65; p = 0.75, respectively).
The host and the flora.
Stange et al., Tübingen, Germany. In Dig Dis, 2012
Commensal species may tolerate intestinal antimicrobial peptides, for example Bacteroides ssp. or Parabacteroides ssp. as major species in the human colon were highly resistant to the constitutive defensin HBD-1 and only susceptible to the inducible defensin HBD-3.
[Human beta-defensin 1: from defence to offence].
Wehkamp et al., Stuttgart, Germany. In Z Gastroenterol, 2012
The human beta-defensin 1 (hBD-1) plays a major role because it is produced constitutively by all human epithelia and some immune cells.
Functional single-nucleotide polymorphisms in the DEFB1 gene are associated with systemic lupus erythematosus in Southern Brazilians.
Crovella et al., Recife, Brazil. In Lupus, 2012
Functional single-nucleotide polymorphisms in the DEFB1 gene are associated with systemic lupus erythematosus in Southern Brazilians.
Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children.
De Rossi et al., Padova, Italy. In Aids, 2012
in children with HIV, TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEFbeta1 -44CG genotype and DEFbeta1 [G;G] haplotype correlated with a better clinical outcome.
Genetic variability in beta-defensins is not associated with susceptibility to Staphylococcus aureus bacteremia.
Andersen et al., Copenhagen, Denmark. In Plos One, 2011
Using a large, unique cohort of pediatric CA-SAB, this study found no significant association between DEFB1 genetic variation or DEFB4/DEFB103 gene copy number and susceptibility for Staphylococcus aureus bacteremia
Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.
Weyrich et al., Salt Lake City, United States. In Plos Pathog, 2011
data demonstrate that hBD-1 is a previously-unrecognized component of platelets that displays classic antimicrobial activity and, in addition, signals PMNs to extrude DNA lattices that capture and kill bacteria
Differential expression of human beta defensins in placenta and detection of allelic variants in the DEFB1 gene from HIV-1 positive mothers.
Rugeles et al., Antioch, Turkey. In Biomedica, 2011
Data suggest that HIV-1 induces a differential expression of human beta defensins, and describe variants of DEFB1, in placenta and suggest these proteins could be involved in protecting against HIV-1 at least early in pregnancy.
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1.
Wehkamp et al., Stuttgart, Germany. In Nature, 2011
reduced hBD-1 shields the healthy epithelium against colonisation by commensal bacteria and opportunistic fungi
(99m)Tc-Human β-defensin-3
Leung, Bethesda, United States. In Unknown Journal, 2009
Similar to HBD-1 and HBD-2, HBD-3 has microbicidal activity toward the Gram-negative bacteria (e.g., Pseudomonas aeruginosa, Escherichia coli) and yeasts.
Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial.
CREATE Investigators et al., Montréal, Canada. In Jama, 2007
the secondary outcome measure was self-reported Beck Depression Inventory II (BDI-II) score (tested at alpha = .017).
Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator.
Gudmundsson et al., Dhaka, Bangladesh. In Nat Med, 2001
infections, expression of the antibacterial peptides LL-37 and human beta-defensin-1 is reduced or turned off.
Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis.
Wilson et al., Philadelphia, United States. In Cell, 1997
A full-length clone for the only known human beta-defensin (i.e., hBD-1) was isolated.
Immortalization of human T lymphocytes after transfection of Epstein-Barr virus DNA.
Volsky et al., In Science, 1986
One of these lines, which has been fully characterized, is termed HBD-1.
McAllister-Williams et al., Southampton, United Kingdom. In Unknown Journal, 0001
RESULTS: The estimated mean difference for each of our study outcomes between randomised groups, 5 weeks post randomisation (allowing for variation between centres and whether or not patients originate from primary or secondary care) was MADRS –0.51 [95% confidence interval (CI) –3.48 to 2.46]; Beck Depression Inventory (BDI) –2.65 (95% CI –6.41 to 1.10); Clinical Anxiety Scale 0.46 (95% CI –1.20 to 2.12); State–Trait Anxiety Inventory 1.2 (95% CI –0.6 to 3.0); European Quality of Life-5 Dimensions 0.015 (95% CI –0.069 to 0.099); EuroQol visual analogue scale 5.6 (95% CI –0.7 to 12.0); and Young Mania Rating Scale –0.04 (95% CI –0.52 to 0.45).
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