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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

C-type lectin domain family 4, member C

BDCA-2, CD303
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD123, CD1c, CAN, CD4, CD11c
Papers using BDCA-2 antibodies
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Zheng Song Guo, In PLoS ONE, 2004
... anti-CD80 (MAB104, Beckman Coulter), anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), anti-CD303 (AC144, Miltenyi Biotec), anti-Foxp3 (259D, eBioscience), anti-CTLA-4 ...
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
Gilliet Michel et al., In The Journal of Experimental Medicine, 2003
... specimens were fixed in acetone, subsequently stained with an excess of primary Ab, including anti–human BDCA-2 mAb (Miltenyi Biotec), anti–human MxA (a gift ...
CXC-chemokine receptor 4 is not a coreceptor for human herpesvirus 7 entry into CD4(+) T cells.
Cornelissen Marion et al., In Archives of Dermatological Research, 1999
... Columbia, MD), CD3 (pan T cell marker; clone SK7, FITC-conjugated; BD Biosciences, San Jose, CA), and BDCA-2 (plasmacytoid dendritic cell marker; clone AC144, FITC conjugated; Miltenyi Biotec, Bergisch Gladbach, Germany) ...
BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction
Schmitz Jürgen et al., In The Journal of Experimental Medicine, 1999
... As determined by staining with PE-conjugated anti–BDCA-2 mAb (AC144; Miltenyi Biotec; reference 19) and flow cytometric analysis using a FACSCalibur™ (Becton Dickinson) and CELLQuest™ software (Becton ...
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development
Blom Bianca et al., In The Journal of Experimental Medicine, 1998
... Anti–BDCA2-PE was obtained from Miltenyi Biotec and anti–NGFR-PE was obtained ...
Papers on BDCA-2
Endogenously produced TNF-α contributes to the expression of CXCL10/IP-10 in IFN-λ3-activated plasmacytoid dendritic cells.
Cassatella et al., Verona, Italy. In J Leukoc Biol, Jan 2016
We report that plasmacytoid dendritic cells incubated with IFN-λ3 prolong their survival; alter their expression pattern of surface HLA-DRα, CD123, CD86, and CD303; and time dependently produce IFN-α, CXCL10/IFN-γ-induced protein 10, and even modest quantities of TNF-α.
Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood: A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses.
Gerl et al., Heidelberg, Germany. In Clin Immunol, Jan 2016
These pDCs express lower BDCA-2 and CD123 and higher HLA-DR and CD11c than Siglec-1-negative pDCs and do not produce IFN-α via TLR7/TLR9 engagement.
Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma.
Komohara et al., Kumamoto, Japan. In Cancer Immunol Res, Dec 2015
High CD169 expression in macrophages could be stimulated by IFNα in vitro, and in RLNs, IFNα-producing macrophages and CD303(+) plasmacytoid dendritic cells were identified surrounding CD169(+) macrophages.
Profiling of primary peripheral blood- and monocyte-derived dendritic cells using monoclonal antibodies from the HLDA10 Workshop in Wollongong, Australia.
Bühring et al., Tübingen, Germany. In Clin Transl Immunology, Nov 2015
Mainly three phenotypically and functionally distinct DC subsets are described in the human peripheral blood (PB): plasmacytoid DCs (pDCs), which express the key marker CD303 (BDCA-2), and two myeloid DC subsets (CD1c(+) DC (mDC1) and CD141(+) DC (mDC2)), which express the key markers CD1c (BDCA-1) and CD141 (BDCA-3), respectively.
[Differential diagnostic specific skin infiltrates in chronic myelomonocytic leukemia].
Fend et al., Tübingen, Germany. In Pathologe, Sep 2015
The skin biopsy showed a perivascular infiltration of medium-sized cells with positivity for CD123, CD303 and CD4 with a low proliferation activity so that a diagnosis of a CMML-associated proliferation of plasmacytoid dendritic cells was made.
Role of Toll-like receptors and retinoic acid inducible gene I in endogenous production of type I interferon in dermatomyositis.
Yan et al., Jinan, China. In J Neuroimmunol, Sep 2015
Immunofluorescence showed extensive co-localization of BDCA-2 with TLR-9 and little co-localization with TLR-7.
Blastic plasmacytoid dendritic cell neoplasm presenting as leukemia without cutaneous involvement in a 25 years male patient: Unusual presentation of a rare entity.
Rahman et al., Lucknow, India. In Indian J Pathol Microbiol, Jul 2015
Characteristic immunophenotype of CD4 + /CD56 +/- cells expressing antigens associated with plasmacytoid dendritic cells like CD123, TCL1, BDCA2/CD303, cutaneous lymphocyte-associated and interferon dependent molecule MxA, in absence of any other lineage specific marker confirms the diagnosis.
[Expression of retinoic acid-I nducible gene I in the muscle tissues of idiopathic inflammatory myopathies].
Yan et al., Jinan, China. In Zhonghua Yi Xue Za Zhi, Jul 2015
We also examined the co-localization of RIG-I and CD303, which is the specific surface marker of plasmacytoid dendridic cells (pDCs), by means of double immunofluorescence staining.
Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation.
Döring et al., München, Germany. In Plos One, 2014
Hence, we investigated the role of pDCs in atherogenesis vs atheroprogression by specifically depleting this cell population using the BDCA2-DTR mouse model bred to Apolipoprotein E (Apoe-/-) deficient mice.
Gut-Associated Plasmacytoid Dendritic Cells Display an Immature Phenotype and Upregulated Granzyme B in Subjects with HIV/AIDS.
Lombardi et al., Kazan', Russia. In Front Immunol, 2014
We observed that subjects with HIV/AIDS had increased infiltration of Ki-67(+)/CD303(+) pDCs, a phenotype consistent with bone marrow-derived pre-pDCs.
A leading role for the immune system in the pathophysiology of preeclampsia.
Laresgoiti-Servitje, Mexico. In J Leukoc Biol, 2013
Furthermore, preeclamptic women have higher levels of nonclassic and intermediate monocytes and lower levels of lymphoid BDCA-2(+) DCs.
Diagnostic and therapeutic advances in blastic plasmacytoid dendritic cell neoplasm: a focus on hematopoietic cell transplantation.
Hamadani et al., Tampa, United States. In Biol Blood Marrow Transplant, 2013
BPDCN frequently expresses CD123, TCL1, BDCA-2, and CD2AP.
The Dectin-2 family of C-type lectin-like receptors: an update.
Brown et al., Aberdeen, United Kingdom. In Int Immunol, 2013
Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell immunoactivating receptor (DCAR), dendritic cell immunoreceptor (DCIR), Dectin-2, C-type lectin superfamily 8 (CLECSF8) and macrophage-inducible C-type lectin (Mincle).
Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides.
Sozzani et al., Brescia, Italy. In J Biol Chem, 2011
Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides.
Immunohistochemical characterisation of dendritic cells in human atherosclerotic lesions: possible pitfalls.
Bult et al., Antwerp, Belgium. In Pathology, 2011
Accumulation of BDCA-1 and BDCA-2 around neovessels showed that mDCs and pDCs are recruited to advanced arteriosclerotic plaques.
Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood.
Bult et al., Antwerp, Belgium. In J Immunol Methods, 2010
Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood.
Indoleamine 2,3-dioxygenase+ cells correspond to the BDCA2+ plasmacytoid dendritic cells in human melanoma sentinel nodes.
Borgognoni et al., In J Invest Dermatol, 2010
Indoleamine 2,3-deoxigenase positive plasmacytoid dentritic cells are the classical BDCA2 positive cells in melanoma lymph nodes
The Dectin-2 family of C-type lectins in immunity and homeostasis.
Brown et al., Cape Town, South Africa. In Cytokine, 2009
This review focuses on the Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes are clustered in the telomeric region of the NK-gene cluster on mouse chromosome 6 and human chromosome 12.
Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells.
Bosisio et al., Brescia, Italy. In Immunobiology, 2008
Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells.
Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2.
Miyachi et al., Kyoto, Japan. In Immunobiology, 2003
Two other lectins, dectin-2 and BDCA-2, are highly related to DCAR by similarities of their amino acid sequence, molecular structure and chromosomal localization.
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