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Beta-carotene oxygenase 2

BCO2, Beta-Carotene Oxygenase 2, BCDO2, beta-carotene dioxygenase-2
This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, ACID, Apo, HAD, STEP
Papers on BCO2
Parallel Selection Revealed by Population Sequencing in Chicken.
Simianer et al., München, Germany. In Genome Biol Evol, Dec 2015
We confirmed parallel fixation in BCDO2 and TSHR genes and found four candidates including AGTR2, a gene heavily involved in "Ascites" in commercial birds.
Xanthophyll supplementation regulates carotenoid and retinoid metabolism in hens and chicks.
Bi et al., Fuzhou, China. In Poult Sci, Dec 2015
UNASSIGNED: This study investigated the effects of xanthophylls (containing 40% lutein and 60% zeaxanthin; Juyuan Biochemical Co., Ltd., GuangZhou, China) on gene expression associated with carotenoid cleavage enzymes (β-carotene 15, 15'-monooxygenase, BCMO1; and β-carotene 9', 10'-dioxygenase, BCDO2) and retinoid metabolism (lecithin:retinol acyl transferase (LRAT) and STRA6) of breeding hens and chicks.
Properties of different selection signature statistics and a new strategy for combining them.
Simianer et al., Beijing, China. In Heredity (edinb), Nov 2015
Our analysis suggests that a set of well-known genes such as BCO2, MC1R, ASIP and TYR were involved in the divergent selection for this trait.
A novel AAT-deletion mutation in the coding sequence of the BCO2 gene in yellow-fat rabbits.
Gugołek et al., Olsztyn, Poland. In J Appl Genet, Nov 2015
One of the main candidate genes associated with the yellow-fat trait is β-carotene 9',10'-oxygenase (BCO2).
Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.
von Lintig et al., Cleveland, United States. In J Biol Chem, Nov 2015
A member of this family, the β-carotene 9,10-dioxygenase (BCO2), converts xanthophylls to rosafluene and ionones.
Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine.
Harrison et al., Columbus, United States. In Arch Biochem Biophys, May 2015
β-Carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) are the two known carotenoid cleavage enzymes in humans.
Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice.
Wang et al., Boston, United States. In J Nutr, Feb 2015
Apo-10'-lycopenoic acid (APO10LA), a potential oxidation product of apo-10'-lycopenal that is generated endogenously by β-carotene-9',10'-oxygenase (BCO2) cleavage of lycopene, inhibited hepatic steatosis in BCO2-expressing mice.
In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.
Costa et al., New York City, United States. In J Toxicol Environ Health A, 2014
Many of the 107 genes are involved in metabolic syndrome and include ALDH4A1, BCO2, CYP1A, CYP2U, TOP2A.
Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.
Wang et al., Boston, United States. In Cancer Prev Res (phila), 2014
We recently showed that apo-10'-lycopenoic acid, a lycopene metabolite generated by beta-carotene-9',10'-oxygenase (BCO2), inhibited carcinogen-initiated, high-fat diet (HFD)-promoted liver inflammation, and hepatic tumorigenesis development.
Evidence for compartmentalization of mammalian carotenoid metabolism.
von Lintig et al., Cleveland, United States. In Faseb J, 2014
The biochemical and molecular identification of a second structurally related β-carotene metabolizing enzyme, BCO2, has led to a prolonged debate about its relevance in vitamin A biology.
Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.
Bernstein et al., Salt Lake City, United States. In Proc Natl Acad Sci U S A, 2014
We focused on β,β-carotene-9',10'-dioxygenase (BCO2, also known as BCDO2), the only known mammalian xanthophyll cleavage enzyme.
The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon.
Våge et al., Portugal. In Gene, 2014
In mammals, two carotenoid cleaving oxygenases are known; beta-carotene 15,15'-monooxygenase (BCMO1) and beta-carotene 9',10'-oxygenase (BCO2).
Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.
Lu et al., Stillwater, United States. In Mol Nutr Food Res, 2014
HD lowered hepatic lutein and zeaxanthin contents, inhibited protein expression of β,β-carotene 9',10'-oxygenase 2 (BCO2) and heat shock protein 60 in mitochondria, increased reactive oxygen species level, and suppressed mitophagy and mitochondrial biogenesis as determined by accumulation of p62, inhibited phosphorylation of Unc-51-like kinase 1 on Ser555, and declined expression of peroxisome proliferator-activated receptor γ coactivator 1 α, resulting in hepatic steatosis in B6 and knockout mice.
Genetic variations involved in interindividual variability in carotenoid status.
Borel, Marseille, France. In Mol Nutr Food Res, 2012
The proteins clearly identified so far are (i) the carotene oxygenases β,β-carotene-15,15'-monooxygenase (BCMO1) and β,β-carotene-9',10'-oxygenase (BCDO2), which are involved in carotenoid cleavage, (ii) scavenger receptor class B type I (SR-BI), cluster determinant 36 (CD36), and Niemann Pick C1-like 1 (NPC1L1), which are involved in carotenoid uptake by cells, and (iii) glutathione S-transferase Pi 1 (GSTP1) and human retinal lutein-binding protein (HR-LBP), which are involved in the transport of xanthophylls in the retina.
Importance of β,β-carotene 15,15'-monooxygenase 1 (BCMO1) and β,β-carotene 9',10'-dioxygenase 2 (BCDO2) in nutrition and health.
Kobayashi et al., Newcastle upon Tyne, United Kingdom. In Mol Nutr Food Res, 2012
The other carotenoid cleavage enzyme β,β-carotene 9',10'-dioxygenase (BCDO2) cleaves β-carotene at the 9',10' double bond forming β-apo-10'-carotenal and β-ionone.
Association between CSN3 and BCO2 gene polymorphisms and milk performance traits in the Czech Fleckvieh cattle breed.
Urban et al., Brno, Czech Republic. In Genet Mol Res, 2011
BCO2 gene (genotypes AA and AG) shows a statistically significant relationship (P = 0.05) with daily milk, protein yield and SCC
Production of β-apo-10'-carotenal from β-carotene by human β-carotene-9',10'-oxygenase expressed in E. coli.
Oh et al., Seoul, South Korea. In Biotechnol Lett, 2011
The gene encoding beta-carotene-9',10'-oxygenase, which cleaves the 9',10' double bond in beta-carotene into beta-apo-10'-carotenal, was cloned and expressed in Escherichia coli.
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.
von Lintig et al., Cleveland, United States. In Faseb J, 2011
we found that the third family member, beta,beta-carotene-9',10'-oxygenase (BCDO2), is a mitochondrial carotenoid-oxygenase with broad substrate specificity
Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colour in bovine adipose tissue and milk.
Bottema et al., Adelaide, Australia. In Anim Genet, 2010
Animals with the BCO2 AA genotype had more yellow beef fat and a higher beta-carotene concentration in adipose tissues than those with the GA or GG genotype.
Mutation in bovine beta-carotene oxygenase 2 affects milk color.
Snell et al., Auckland, New Zealand. In Genetics, 2009
The BCO2 enzyme is identified as a key regulator of beta-carotene metabolism.
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