GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
B-cell CLL/lymphoma 9
BCL9, LGs, LGSN
BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
CAN, SIMPLE, Lacrimal, ACID, HAD
Papers on
BCL9
Regulation of isoprenoid pheromone biosynthesis in bumblebee males.
New
Praha, Czech Republic. In Chembiochem, Jan 2016
Contrary, in B. lucorum, transcript abundances of AACT, HMGR, and FPPS were low and AACT activity was not detected in B. lucorum LGs.
Lacrimal Gland Inflammation Deregulates Extracellular Matrix Remodeling and Alters Molecular Signature of Epithelial Stem/Progenitor Cells.
New
Los Angeles, United States. In Invest Ophthalmol Vis Sci, Jan 2016
PURPOSE: The adult lacrimal gland (LG) is highly regenerative and is able to repair itself even after substantial damage; however, this ability to regenerate is lost with the development of dry eye conditions in chronically inflamed LGs.This study compares changes in the cell adhesion and cell matrix molecules and stem cell transcription factors in the LGs of healthy mice and of two mouse models of Sjögren's syndrome: nonobese diabetic (NOD) and MRL-lpr/lpr (MRL/lpr) mice during the early stage of inflammation.
[Association of BCL9 expression with prostate cancer clinicopathological features and survival].
New
Dongguan, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
OBJECTIVE: B-cell lymphoma 9 (BCL9) as a co-activator for β-catenin-mediated transcription is highly expressed in tumors.
The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.
New
Impact
Boston, United States. In Nat Med, Jun 2015
The expression and secretion of eCyPA by BMECs was enhanced by BCL9, a Wnt-β-catenin transcriptional coactivator that is selectively expressed by these cells.
High-density genetic map construction and gene mapping of pericarp color in wax gourd using specific-locus amplified fragment (SLAF) sequencing.
Guangzhou, China. In Bmc Genomics, 2014
And finally, 4,607 of the polymorphic markers were selected for genetic map construction, and 12 linkage groups (LGs) were generated.
[β-Catenin: Structure, Function and Role in Malignant Transformation of Epithelial Cells].
Review
In Vestn Ross Akad Med Nauk, 2014
Primary structure of β-catenin allows it to interact with many factors and ligands, including transcription factors, α-catenin, cadherin, Axin, Rho family GTPases, Bcl9 et al.
A high-density genetic map for anchoring genome sequences and identifying QTLs associated with dwarf vine in pumpkin (Cucurbita maxima Duch.).
Beijing, China. In Bmc Genomics, 2014
Three QTLs on linkage groups (LGs) 1, 3 and 4, respectively, were recovered.
Major Quantitative Trait Loci and Putative Candidate Genes for Powdery Mildew Resistance and Fruit-Related Traits Revealed by an Intraspecific Genetic Map for Watermelon (Citrullus lanatus var. lanatus).
Miryang, South Korea. In Plos One, 2014
The map consists of 14 linkage groups (LGs) defined by 174 cleaved amplified polymorphic sequences (CAPS), 2 derived-cleaved amplified polymorphic sequence markers, 20 sequence-characterized amplified regions, and 8 expressed sequence tag-simple sequence repeat markers spanning 1,404.3
Crosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: implications for multiple myeloma therapy.
Review
Boston, United States. In Cancer Res, 2014
Because BCL9 is a critical transcriptional coactivator of β-catenin that is aberrantly expressed in many human cancers but is of low abundance in normal tissues, [corrected] the Wnt/β-catenin/BCL9 complex has emerged as a promising and most likely relatively safe therapeutic target in cancers with dysregulated Wnt/β-catenin activity.
Harlequin ichthyosis: ABCA12 mutations underlie defective lipid transport, reduced protease regulation and skin-barrier dysfunction.
Review
London, United Kingdom. In Cell Tissue Res, 2013
ATP-binding cassette transporter A12 (ABCA12) is a member of the subfamily of ATP-binding cassette transporters and functions to transport lipid glucosylceramides (GlcCer) to the extracellular space through lamellar granules (LGs).
MicroRNA-30c-2* expressed in ovarian cancer cells suppresses growth factor-induced cellular proliferation and downregulates the oncogene BCL9.
GeneRIF
Athens, United States. In Mol Cancer Res, 2011
growth factor induced proliferation mediates a neutralizing response by significantly increasing miR-30c-2* which reduces BCL9 expression and cell proliferation in SKOV-3 and OVCAR-3 cells
Common variants in the BCL9 gene conferring risk of schizophrenia.
GeneRIF
Shanghai, China. In Arch Gen Psychiatry, 2011
These findings indicate that common variations in the BCL9 gene confer risk of schizophrenia and may also be associated with bipolar disorder and major depressive disorder in the Chinese Han population.
Generation and detection of levuglandins and isolevuglandins in vitro and in vivo.
Review
Wuhan, China. In Molecules, 2010
Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl ε-amino groups.
Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.
GeneRIF
Cambridge, United Kingdom. In J Mol Biol, 2010
Pygo2 PHD is the only known PHD finger that is capable of interacting simultaneously with two functional ligands, B9L and BCL9
Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation.
GeneRIF
Kodaira, Japan. In J Neurosci, 2010
These results indicate that the ZNRF1-GS system may play an important role in correlating Schwann cell metabolism with its differentiation.
BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.
GeneRIF
Boston, United States. In Cancer Res, 2009
Findings suggest that deregulation of BCL9 is an important contributing factor to tumor progression in multiple myeloma and colon neoplasms.
Structural dynamics and folding of beta-lactoglobulin probed by heteronuclear NMR.
Review
Suita, Japan. In Biochim Biophys Acta, 2009
Recently, the expression of various types of recombinant beta LGs combined with heteronuclear NMR analysis has significantly improved understanding of the physico-chemical properties of beta LG.
Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.
Impact
GeneRIF
Cambridge, United Kingdom. In Nat Cell Biol, 2004
Pygo and Lgs function in targeting Armadillo/beta-catenin to the nucleus, thus ensuring its availability to TCF during Wnt signalling.
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.
Impact
Zürich, Switzerland. In Cell, 2002
Here we report the identification of two segment polarity genes in Drosophila, legless (lgs), and pygopus (pygo), and we show that their products are required for Wnt signal transduction at the level of nuclear beta-catenin.
