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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

BCL2-like 14

Bcl-G, BCL2L14, BCL2-like 14
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: bcl-2, Ubiquitin, CAN, MKP-7, ETV6
Papers on Bcl-G
An RNA interference screen identifies new avenues for nephroprotection.
Kandel et al., Buffalo, United States. In Cell Death Differ, Dec 2015
We used an RNA interference screen to identify genes (BCL2L14, BLOC1S2, C2ORF42, CPT1A, FBP1, GCNT3, RHOB, SCIN, TACR1, and TNFAIP6) whose suppression improves survival of kidney epithelial cells in in vitro models of oxygen and glucose deprivation.
Ubiquitin-like protein MNSFβ covalently binds to cytosolic 10-formyltetrahydrofolate dehydrogenase and regulates thymocyte function.
Notsu et al., Izumo, Japan. In Biochem Biophys Res Commun, Oct 2015
Previous studies have demonstrated that MNSFβ covalently binds to various target proteins including Bcl-G, a proapoptotic protein.
Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
Wang et al., Shanghai, China. In Mol Reprod Dev, Jun 2015
The uterine Day-5 abundance of P53, BAX, and BCL-G in pregnant Mnsfb(+/-) mice was significantly decreased compared to that of wild-type mice, whereas the expression of P27 and tumor necrosis factor alpha (TNFA) was elevated.
Ubiquitin-like protein MNSFβ negatively regulates T cell function and survival.
Watanabe et al., Izumo, Japan. In Immunol Invest, 2014
Previous studies have demonstrated that MNSFβ covalently binds to intracellular pro-apoptotic protein Bcl-G and regulates apoptosis in macrophages.
Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype.
Steinemann et al., Hannover, Germany. In Bmc Genomics, 2013
ETV6 and CDKN1B had reduced expression levels in CK-AML patients with deletion in 12p13 as compared to CK-AML without deletion in 12p13, while the other genes (BCL2L14, LRP6, DUSP16 and GPRC5D) located within the minimal deleted region in 12p13 had very low or missing expression in CK-AML irrespective of their copy number status.
Genome-wide analysis of DNA methylation in tongue squamous cell carcinoma.
Ling et al., Changsha, China. In Oncol Rep, 2013
In addition, another three genes (BCL2L14, CDCP1 and DIRAS3) were tested by RT-PCR.
Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide/interferon γ-induced apoptosis in macrophages.
Nakamura et al., Izumo, Japan. In Febs J, 2013
Previous studies have demonstrated that MNSFβ covalently binds to intracellular pro-apoptotic protein Bcl-G and regulates the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) cascade in the mouse macrophage cell line Raw264.7.
Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.
Moorman et al., Newcastle upon Tyne, United Kingdom. In Genes Chromosomes Cancer, 2013
The centromeric deletion encompassed the following genes: LRP6, BCL2L14, DUSP16, CREBL2, and CDKN1B.
BCL-G as a new candidate gene for immune responses in pigs: bioinformatic analysis and functional characterization.
Zhang et al., Xi'an, China. In Vet Immunol Immunopathol, 2012
BCL-G, also known as Bcl2-like14, is a unique member of the Bcl-2 family that plays an important role in regulating apoptosis in humans.
Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.
Amos et al., Houston, United States. In Cancer Epidemiol Biomarkers Prev, 2012
Two of these variants (a BCL2L14 SNP in former smokers and an SNP in IL2RB in current smokers) were further validated.
Ubiquitin-like protein MNSFβ regulates TLR-2-mediated signal transduction.
Watanabe et al., Izumo, Japan. In Mol Cell Biochem, 2012
Previous studies have demonstrated that MNSFβ covalently binds to the intracellular pro-apoptotic protein Bcl-G and regulates TLR-4-mediated signal transduction.
A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers.
Ryan et al., Cambridge, United States. In Mol Biosyst, 2012
RAB33A, RAB6A and BCL2L14), transcription factors (e.g.
Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study.
Levis et al., Pisa, Italy. In J Hematol Oncol, 2011
RESULTS: ATO treatment induced up-regulation of some pro-apoptotic genes, such as HRK, BAK1, CASPASE-5, BAD, TNFRSF1A, and BCL2L14 and down-regulation of ICEBERG.
Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies.
Bouillet et al., Melbourne, Australia. In Cell Death Dis, 2011
Bcl-G is an evolutionarily conserved member of the Bcl-2 family of proteins that has been implicated in regulating apoptosis and cancer.
Bcl-2 family member Bcl-G is not a proapoptotic protein.
Bouillet et al., Melbourne, Australia. In Cell Death Dis, 2011
One of them, Bcl-G, has a BH2 and a BH3 region, and was proposed to trigger apoptosis.
Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G.
Williams et al., United Kingdom. In Biochim Biophys Acta, 2011
prior knockdown of Bcl-G expression ablates the stimulation of basal apoptosis by FAU, consistent with an essential downstream role for Bcl-G, itself a candidate tumour suppressor, in mediating the apoptosis regulatory role of FAU.
Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus.
Wu et al., Chongqing, China. In Clin Immunol, 2009
Increased BclG(L) expression may contribute to the aberrant CD4+ T cell apoptosis which causes an inappropriate immune response and impaired homeostasis in systemic lupus erythematosus.
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
Williams et al., United Kingdom. In Breast Cancer Res, 2008
siRNA downregulation of Bcl-G inhibited breast cancer cell apoptosis. Adding an siRNA against Fau revealed control of Bcl-G by Fau. The most important factors controlling Bcl-G are post-translational modification by Fau & MELK, not transcription rate.
JAB1 accelerates mitochondrial apoptosis by interaction with proapoptotic BclGs.
He et al., Beijing, China. In Cell Signal, 2008
JAB1 is involved in the regulation of mitochondrial apoptotic pathway through specific interaction with BclGs.
Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas.
Lee et al., Seoul, South Korea. In Tumori, 2007
data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma
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