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B-cell CLL/lymphoma 2

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bax, PrP, CAN, p53, V1a
Papers using bcl-2 antibodies
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene.
Kim Baek, In PLoS ONE, 2010
... anti-tubulin monoclonal and anti-myc polyclonal antibody from Sigma; anti-PARP monoclonal antibody, anti-CHOP/GADD153 monoclonal antibody and anti-Bcl-2 monoclonal antibody from Cell Signaling Technology (Cell Signaling Technology, ...
The RB-E2F1 pathway regulates autophagy.
Fimia Gian Maria, In PLoS ONE, 2010
... Stable empty vector control cells and Bcl-2 over-expressing clones were generated using standard gene transfer techniques and selection in Geneticin (Life Technologies).
Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF.
Bauer Joseph Alan, In PLoS ONE, 2009
... Antibodies against Bcl-2 (N-19) and 14-3-3 (C-16) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
He You-Wen et al., In Cell death and differentiation, 2008
... Bcl-2-transgenic mice ...
Microtubules and cadherins: a neglected partnership.
Ushio-Fukai Masuko, In PLoS ONE, 2008
... Lake Placid, NY), mouse anti-phospho-Erk1/2 (1/10000; Sigma), mouse anti-Bcl-2 (1/500; Transduction Laboratories, Becton Dickinson Europe, Le Pont de ...
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Papers on bcl-2
Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biologic heterogeneity of the disease.
Shipp et al., Boston, United States. In Blood, Feb 2016
The remaining 2 DLBCL PDX models were GCB-type, with characteristic alterations of GNA13, CREBBP and EZH2, and chromosomal translocations involving IgH and either BCL2 or MYC.
Venetoclax Adds a New Arrow Targeting Relapsed CLL to the Quiver.
Byrd et al., Columbus, United States. In Cancer Cell, Feb 2016
A recent paper by Roberts and colleagues describes an additional therapeutic target by reporting encouraging clinical results with venetoclax, an inhibitor of the antiapoptotic protein BCL2.
The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell line.
Samadi et al., Tabrīz, Iran. In Bosn J Basic Med Sci, Feb 2016
Applying quantitative real-time polymerase chain reaction, we measured Six1, B-cell lymphoma/leukemia(BCL-2), BAX, and P53 mRNA expression levels in both non-resistant and resistant cells.
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Zhou et al., Little Rock, United States. In Nat Med, Jan 2016
To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug.
Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining.
Palazzo et al., Catania, Italy. In Pathol Res Pract, Jan 2016
The diagnosis was confirmed in the excised specimen, which exhibited a tumor with an immunohistochemical profile consistent with SFT, including diffuse expression of CD34, CD99 and bcl2.
Novel targeted therapeutics for mantle cell lymphoma - What's on the horizon?
Ribrag et al., Villejuif, France. In Expert Rev Hematol, Jan 2016
Several other molecules are currently being evaluated such as cyclin dependent kinase 4/6 (CDK4/6), phosphoinositide 3-kinase (PI3K), B cell lymphoma-2 (BCL2) and Poly ADP-ribose polymerase (PARP) inhibitors.
The Deadly Landscape Of Pro-Apoptotic BCL-2 Proteins In the Outer Mitochondrial Membrane.
Chipuk et al., New York City, United States. In Febs J, Jan 2016
In the past two decades, significant efforts have focused on understanding the function of the BCL-2 proteins, a complex family of pro-survival and pro-apoptotic alpha helical proteins that directly control the mitochondrial pathway of apoptosis.
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia.
Seymour et al., Melbourne, Australia. In N Engl J Med, Jan 2016
Venetoclax has a distinct mechanism of action; it targets BCL2, a protein central to the survival of CLL cells.
Using the pathology report in initial treatment decisions for diffuse large B-cell lymphoma: time for a precision medicine approach.
Friedberg, Rochester, United States. In Hematology Am Soc Hematol Educ Program, Jan 2016
Rearrangement of the myc oncogene occurs in ∼10% of patients with DLBCL, and confers a very poor prognosis with standard R-CHOP, particularly when there is concomitant rearrangement of bcl-2, a condition referred to as "double-hit" DLBCL.
Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
Im et al., Kwangju, South Korea. In Sci Rep, Dec 2015
NFAT1 KO T cells displayed a reduced expression of apoptosis associated BCL-2/BH3 family members.
Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.
Datta et al., Karnāl, India. In Domest Anim Endocrinol, Dec 2015
FSH supplementation in in vitro maturation-medium resulted in a dose-dependent reduction in the expression of proapoptotic genes namely, BCL2-associated X protein (BAX), cytochrome c, and caspase-3 and increase in the expression of antiapoptotic genes such as B-cell lymphoma 2 (BCL2) and X-linked inhibitor of apoptosis protein (XIAP) in cumulus cells of mature oocyte.
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
Radlwimmer et al., Leipzig, Germany. In Nat Genet, Nov 2015
Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples.
Double-hit and double-protein-expression lymphomas: aggressive and refractory lymphomas.
Coiffier et al., Lyon, France. In Lancet Oncol, Nov 2015
Double-hit lymphoma (DHL) is a subgroup of aggressive lymphomas with both MYC and BCL2 gene rearrangements, characterised by a rapidly progressing clinical course that is refractory to aggressive treatment and short survival.
Genomic classification of lung cancer: toward a personalized treatment.
El Mezni et al., In Tunis Med, Jun 2015
This has been reported to an inactivation of PTEN resulting in an activation of the PI3K pathway (8).Other authors reported the amplification of the proto-oncogene MET orthe BCl2-interacting mediator of cell death (BIM) (9).
Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective.
Shin et al., Seoul, South Korea. In Int J Mol Sci, 2014
TOB1 antagonizes the v-akt murine thymoma viral oncogene (AKT) signaling and induces cancer cell apoptosis by activating BCL2-associated X (BAX) protein and inhibiting the BCL-2 and BCL-XL expressions.
Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2.
Li et al., Hangzhou, China. In Febs Lett, 2012
Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2
BCL2 genetic variants are associated with acute kidney injury in septic shock*.
Christiani et al., Boston, United States. In Crit Care Med, 2012
Genotyping reveals two single nucleotide polymorphisms in the BCL2 gene and a single nucleotide polymorphism in the SERPINA4 gene associated with a decreased risk of developing acute kidney injury.
Biomarkers of progestin therapy resistance and endometrial hyperplasia progression.
Garcia et al., Seattle, United States. In Am J Obstet Gynecol, 2012
No association was found between Bcl-2 expression and disease persistance/progression in endometrial hyperplasia treated with progestins.
Clinical value of serum hepatocyte growth factor, B-cell lymphoma-2 and nitric oxide in primary breast cancer patients.
Ramadan et al., Cairo, Egypt. In Eur Rev Med Pharmacol Sci, 2012
Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis.
The clinicopathological significance of Bax and Bcl-2 protein expression with tumor infiltrating lymphocytes in ovarian carcinoma.
Cakalagaoglu et al., İzmir, Turkey. In Neoplasma, 2011
Low bcl-2 expression is associated with response to therapy in ovarian carcinoma.
More papers using bcl-2 antibodies
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
Migliaccio Antimo, In PLoS ONE, 2008
... Antibodies were obtained from the following sources: monoclonal mouse anti Bcl-2 (Santa Cruz Biotechnology, sc-7382), polyclonal rabbit anti ...
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
Koch Troels et al., In Nucleic Acids Research, 2008
... The anti-Bcl-2 monoclonal antibody was purchased from Dako (Carpinteria, CA, USA) ...
Nonpharmacological approaches to improve bone health and reduce osteoporosis.
Kalinichenko Vladimir V., In PLoS ONE, 2007
... BCL2 transgenic mice at 2 weeks (E), ...
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
Delabie Jan et al., In Journal of Hematopathology, 2007
... Fluorescent in situ hybridization analysis was performed on formalin-fixed tissue specimens, using a BCL-2 split signal DNA probe (Y5407, DAKO Cytomation, Denmark A/S) ...
Apoptosis signal-regulating kinase 1 in stress and immune response
Shi Xianglin et al., In Chemical Research in Toxicology, 2007
... Bcl-2 was purchased from DAKO, anticatalase antibody was from ...
Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53.
Sanchis Daniel, In PLoS ONE, 2006
... Anti–Bcl-2 (Ab-1) antibody was purchased from Merck Biosciences (Darmstadt, Germany) ...
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Nilsson G et al., In Cell Death & Disease, 2006
... bcl-2-transgenic mice have been described ...
Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markers
Vega-Memije Elisa et al., In Medicina Oral, Patología Oral y Cirugía Bucal, 2006
... were incubated for 40 minutes at room temperature with monoclonal antibodies against p53 (NCI-953DO-7) and bcl-2 proteins (mouse clone 124), both antibodies were purchased from Dako (Carpinteria, CA) ...
Pulmonary and systemic effects of inhaled PACAP38 in healthy male subjects
Kojro Elzbieta et al., In The FASEB Journal, 2006
... Munich, Munich, Germany) as an antibody against the C terminus of human APP; anti-neprilysin (56C6) and anti-Bcl-2 (C-2; Santa Cruz Biotechnology, Heidelberg, Germany); and anti-pro-brain-derived ...
Neuronal conduction of excitation without action potentials based on ceramide production
Hoheisel Jörg D., In PLoS ONE, 2006
... Antibody to Bcl-2 came from Dako (Glostrup, Denmark) ...
Type I interferons protect neonates from acute inflammation through interleukin 10–producing B cells
Moldawer Lyle L. et al., In The Journal of Experimental Medicine, 2006
... Overexpression of Bcl-2 in transgenic mice decreases apoptosis and ...
Improving the solubility and pharmacological efficacy of curcumin by heat treatment
Liu Quentin et al., In Journal of Translational Medicine, 2006
... Anti-cleaved PARP, cleaved caspase-3, and Bcl-2 antibodies were purchased from Cell Signaling Technologies (Beverly, MA, USA) ...
Elimination of surface debris generated by KrF excimer laser ablation of polyimide
Jones Arwyn T. et al., In Molecular therapy : the journal of the American Society of Gene Therapy, 2005
... L-NuBCP-9-R8 was from Thermo Fisher Scientific (Ulm, Germany), D-NuBCP-9-r8 (Bcl-2 Converter) was from Merck KGAa (Darmstadt, Germany) and ...
Mechanisms involved in Jurkat cell death induced by oleic and linoleic acids
Wu Chun Fu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2005
... The antibodies for caspase-3 and Bcl-2 were purchased from BD Biosciences (San Diego, CA), while ...
Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis
Cuzzocrea Salvatore et al., In PPAR Research, 2005
... The primary antibodies directed at Bax and Bcl-2 was obtained from Santa Cruz Biotechnology, Inc ...
Combined Adjuvant Cisplating and Ifosfamide Chemotherapy and Radiotherapy for Malignant Mixed Mullerian Tumors of the Uterus
Diudea Dana et al., In World Journal of Surgical Oncology, 2005
... Bcl-2Clone 1241/20Dako ...
Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis
Masawa Nobuhide et al., In Head and Neck Pathology, 2004
... Dako), 1B16 (CD56; Novocastra), 5A4 (p80; Novocastra), SP4 (Cyclin D1; Nichirei Co., Tokyo, Japan), 124 (bcl-2; Dako), AE1/3 (cytokeratin; Dako) and ...
An essential role for c-FLIP in the efficient development of mature T lymphocytes
Shapiro Virginia Smith et al., In The Journal of Experimental Medicine, 2004
... Al Singer for the Bcl-2 transgenic mice ...
Bcl-2 as prognostic factor in head and neck squamous cell carcinoma
Zhang Qiyu et al., In World Journal of Surgical Oncology, 2004
... Anti-Bcl-2 BH3 (AP1303a) was from Abgent.
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Bondada Subbarao et al., In Molecular Cancer, 2004
... Antibodies against total Lck, Lyn, Blk, Igα, cyclin D2, Egr-1(C-19), ERK1, Bcl-XL and Bcl-2 were obtained from Santa Cruz Biotechnology, Inc ...
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
Abdel-Naim Ashraf B., In PLoS ONE, 2003
... Polyclonal antibodies against beta-actin, caspase-3, PARP, cytochrome c, Bcl-2, Tom-40 and FITC-conjugated secondary antibodies were purchased from Santa Cruz Biotechnology Inc ...
Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning
Liu Ke et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Anti-Bax and anti-Bcl-2 were obtained from Cell Signaling Technology (USA) ...
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
Nadel Bertrand et al., In The Journal of Experimental Medicine, 2003
... bcl-2-immunoglobulin transgenic mice demonstrate extended B cell ...
Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathways
Kluger Yuval et al., In Breast Cancer Research : BCR, 2002
... overnight incubation with mouse anti-Bag-1 IgG (Chemicon, Temecula, CA, USA) at 1:400 and with mouse anti-Bcl-2 IgG (Dako Corp., Carpinteria, CA, USA) ...
Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells.
Prow Tarl Wayne, In PLoS ONE, 2002
... The primary antibodies for Caspase 3, Caspase 8, Caspase 9, PARP-1, Bid, Bax, Bad and Bcl-2 were purchased from Cell Signaling, MA, USA ...
Role of the p38 MAPK pathway in cisplatin-based therapy
Castresana Javier S., In PLoS ONE, 2002
... Antibodies specific for rabbit JNK, P-JNK (Thr183/tyr185), c-Jun, P-c-Jun (Ser63), survivin, bcl-2, PARP were obtained from Cell Signaling Technology (Beverly, MA) ...
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
Villunger Andreas et al., In The Journal of Cell Biology, 2002
... vav-bcl-2 transgenic mice (provided by J ...
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
Wendel Hans-Guido et al., In The Journal of Experimental Medicine, 2002
... VavP-Bcl2 transgenic mice develop follicular lymphoma ...
B Cell–specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deficient Mice
Wirth Thomas et al., In The Journal of Experimental Medicine, 2001
... , Bcl2-22 transgenic (Bcl2 tg), Bcl2 ...
Topographic association of gastric epithelial expression of Ki-67, Bax, and Bcl-2 with antralization in the gastric incisura, body, and fundus
Simopoulos Konstantinos et al., In Gastroenterology Research and Practice, 2001
... calculation, four slides carrying two-sections each were immunohistochemically examined for the p53, Ki-67, Bax, and Bcl-2 expression (Biogenex Laboratories, Inc., San Ramon, ...
The nitric oxide donor NOC12 protects cultured astrocytes against apoptosis via a cGMP-dependent mechanism
Ikejima Takashi et al., In Journal of Korean Medical Science, 2001
... Rabbit polyclonal antibodies against PARP, ICAD, Bax, AIF and mouse polyclonal antibody against Bcl-2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, U.S.A.) ...
Effect of intravenous bisphosphonates on release of basic fibroblast growth factor in serum of patients with cancer-associated hypercalcemia
Body J-J et al., In British Journal of Cancer, 2001
... The mouse bax and bcl-2 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Stein Harald et al., In Virchows Archiv, 2001
... BCL2124Citrate1:25Dako ...
Design-based stereological methods for counting neurons
Bao Jianxin et al., In Molecular Neurodegeneration, 2001
... to reduce the possibility of effects of other genes co-segregating with the bcl-2 transgene, the Bcl-2 over-expressing transgenic mice were backcrossed to ...
Cdk5 phosphorylates p53 and regulates its activity.
Rich Benjamin Edward, In PLoS ONE, 2001
... to β-actin, Tau, β tubulin III, RARα, RARβ, p-ERK p-JNK, p-p38, p21, caspase 3, Bax, Bcl-2 and HRP-labeled secondary anti-goat, anti-mouse, and anti-rabbit antibodies were all purchased from Santa Cruz Biotechnology (Santa Cruz, USA) ...
iNOS and nitrotyrosine expression after spinal cord injury
Cuzzocrea Salvatore et al., In Naunyn-Schmiedeberg's Archives of Pharmacology, 2000
... ), or with anti-Bcl-2 polyclonal antibody (Santa Cruz Biotechnology, DBA, Milan, Italy) ...
Effect of alisol B acetate, a plant triterpene, on apoptosis in vascular smooth muscle cells and lymphocytes
Lupiáñez José A et al., In BMC Cancer, 2000
... Anti-Bax, anti-Bcl-2, anti-cytochrome-c and secondary antibodies were from Santa Cruz Biotechnology (California, USA) ...
c-Myc Is a Critical Target for C/EBPα in Granulopoiesis.
Covas Dimas Tadeu, In PLoS ONE, 2000
... BCL-2 transgenic, and RAG-2 ...
Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim
Heath William R. et al., In The Journal of Experimental Medicine, 2000
... bcl-2 transgenic lines were used: ...
Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide
Condie Brian G. et al., In The Journal of Cell Biology, 2000
... Polyclonal anti-cleaved caspase 3 rabbit IgG, monoclonal anti-Bcl-2 mouse IgG, and monoclonal anti-phospho Bcl-2 antagonist of death mouse IgG were purchased from Cell Signaling.
A contribution to the diagnosis of the small dentigerous cyst or the paradental cyst
Keszler Alicia et al., In International Journal of Dentistry, 2000
... to the cell proliferation-associated antigen Ki-67 (Dako-Denmark) dilution 1 : 100, and monoclonal antibody to the oncoprotein bcl-2 (Novocastra-Leica, New CastleUK) dilution 1 : 100, ...
Deficiency of the stress kinase p38α results in embryonic lethalitycharacterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
Strasser Andreas et al., In The Journal of Experimental Medicine, 1999
... vav-bcl-2-68 and -69 transgenic mouse strains expressing a human ...
Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
Bogen Bjarne et al., In The Journal of Experimental Medicine, 1999
... VavP-Bcl2 transgenic mice develop follicular lymphoma ...
NMR-based screening of proteins containing C-13-labeled methyl groups
McFadden Grant, In PLoS Pathogens, 1999
... v-Bcl-2 transgenic mice were generated as ...
Caspase knockoutsmatters of life and death
Yuan Junying et al., In The Journal of Cell Biology, 1998
... Bcl-xL/S polyclonal antibody and Bcl-2 monoclonal antibody were purchased from Santa Cruz Biotechnology, Inc ...
Effect of recombinant human erythropoietin on endothelial cell apoptosis
Kim Woo Taek et al., In Korean Journal of Pediatrics, 1998
... Primary antibodies included the following: Bcl-2 (1:1,000; Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
Major Histocompatibility Complex Class II Presentation of Cell-associated Antigen Is Mediated by CD8α+ Dendritic Cells In Vivo
Townsend Sarah E. et al., In The Journal of Experimental Medicine, 1998
... Bcl-2 transgenic mice in the B6 ...
Cytolytic T lymphocyte-associated antigen-4 and the TcRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
Wölfl Stefan, In PLoS ONE, 1998
... anti-phospho AKT (Thr-308) from New England Biolabs (Hertfordshire, UK), anti-BcL-XL from Cambridge Bioscience (Cambridge, UK), anti-BcL-2 from BD Biosciences (Oxford, UK) ...
Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone
Varma Neelam et al., In BMC Cell Biology, 1998
... Specific antibodies against cyclin D and Bcl-2 were obtained from Santa Cruz Biotechnology, Inc ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Sviland Lisbet et al., In Virchows Archiv, 1998
... Apoptosis-related protein FasL with antibodies from Alexis Biochemicals, San Diego, CA, USA, Fas, Bax and Bcl-2 with antibodies from Santa Cruz Biotechnology, Santa Cruz, California, USA ...
Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells
Sprent Jonathan et al., In The Journal of Experimental Medicine, 1998
... ) and Bcl-2 transgenic ( ...
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
Asano T et al., In British Journal of Cancer, 1997
... Technology Inc.), cleaved poly(ADP-ribose) polymerase (PARP) (Cell Signaling Technology Inc.), Bcl-xl (Cell Signaling Technology Inc.), Bcl-2 (Cell Signaling Technology Inc.), HIF1 ...
The Bcl-2 protein family: arbiters of cell survival
Zhang Lubo et al., In International Journal of Medical Sciences, 1997
... Bcl-2 antibody was from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk
Andersson Jan et al., In The Journal of Experimental Medicine, 1997
... Eμ–bcl-2 transgenic B6 ...
Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
Baron Roland et al., In The Journal of Cell Biology, 1997
... purchased from Oncogene Research Products, anti-avian-Src antibody from Upstate Biotechnology, anti-Golgi 58K antibody from Sigma-Aldrich, anti-Bcl-2 antibody from Santa Cruz Biotechnology, Inc., and anti-CoxI, -CoxII, ...
Expression of α-catenin in α-catenin–deficient cells increases resistance to sphingosine-induced apoptosis
Ozawa Masayuki et al., In The Journal of Cell Biology, 1997
An mAb against Bcl-2 was obtained from Santa Cruz Biotechnology, Inc ...
Injected cytochrome c induces apoptosis
Martinou Jean-Claude et al., In The Journal of Cell Biology, 1997
... Rabbit pAb raised against amino acids 4–21 of human Bcl-2 was from Santa Cruz Biotechnology ...
Inhibition of HIV-1 infection by the beta-chemokine MDC
Sideras Paschalis et al., In The Journal of Experimental Medicine, 1996
... RAG-2–deficient, bcl-2 transgenic pro B cells (R2BFL) and ...
Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of primary and committed T cells in EAU
Caspi Rachel R. et al., In The Journal of Experimental Medicine, 1996
... Bcl-2 transgenic mice expressing human Bcl-2 ...
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
Sarand Inga et al., In Virus Research, 1996
... The spliced sequences encoding the mouse Bcl-2 alpha protein (locus AAA37282), the EMCV-IRES (pIRES2-EGFP; BD Clontech) and the 148 bp CR-IRES ...
A common inhibitory receptor for major histocompatability complex class I molecules on human lymphoid and myelomonocytic cells
Cyster Jason G. et al., In The Journal of Experimental Medicine, 1996
... , Bar Harbor, ME) were mated with B6 MD4 Ig-transgenic mice and with bcl2-22–transgenic mice (22; more than ...
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
Tohyama Masaya et al., In The Journal of Cell Biology, 1996
... mAb (19; Transduction), anti–caspase-7 mAb (4G2; MBL International Corporation), anti–β-actin mAb (C4; CHEMICON International Inc.), anti–Bcl-2 mAb (#100; BD Biosciences), Alexa 588–conjugated anti–mouse IgG ...
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control
Gerondakis Steve et al., In The Journal of Experimental Medicine, 1996
... ) mice and Eμ-bcl-2-36 transgenic mice, which express a human ...
The cyclin dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker
Penninger Josef M. et al., In The Journal of Experimental Medicine, 1996
... p53 gene–deficient, Bcl-2 transgenic (Tg), DO.11.10 OVA TCR-α/β ...
Bcl-2 prevents nitric oxide-mediated apoptosis and poly(ADP-ribose) polymerase cleavage
Porter Alan G. et al., In Nucleic Acids Research, 1996
... The antibodies against Bcl-2 were from Upstate Biotechnology or Santa Cruz Biotechnology.
BCL11B is required for positive selection and survival of double-positive thymocytes
Avram Dorina et al., In The Journal of Experimental Medicine, 1995
... Al Singer (NCI) for the BCL2 transgenic mice.
Molecular thanatopsis: a discourse on the BCL2 family and cell death
Jung Y-K et al., In British Journal of Cancer, 1995
... (M-125, SC-7195) antibodies were purchased from Santa Cruz (Santa Cruz, CA, USA); anti-Bcl-2 antibody was from DAKO (Copenhagen, Denmark); anti-caspase-8 and ...
Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell–derived neural transplants
Condie Brian G. et al., In The Journal of Cell Biology, 1995
... nestin mouse monoclonal IgG (clone Rat 401), anti-desmin mouse monoclonal IgG (clone RD 301), and anti-Bcl-2 monoclonal mouse IgG (clone 7) were obtained from BD Biosciences.
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
Rintoul R C et al., In British Journal of Cancer, 1994
... -Integrin was detected using CD29 antibody diluted 1 : 100 (Novocastra, Newcastle, UK), and Bcl-2 was detected using Clone 124 antibody diluted 1 : 200 (Dako, Glostrup, Denmark) ...
Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates
Shuai Xintao et al., In International Journal of Nanomedicine, 1994
... FITC-siRNA, Bcl-2 siRNA, Rabbit anti-human Bcl-2 antibody and horseradish peroxidase (HRP)-conjugated goat anti-rabbit antibody were purchased from Cell Signaling Technology (CST, USA) ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... (1:200, sc-28226, Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-Bcl-xL (1:500, 610209, BD Transduction Laboratories), anti-Bcl-2 (1:200, sc-492, Santa Cruz Biotechnology), anti-p-eIF2 ...
Pharmacology of oleanolic acid and ursolic acid.
Bauer Joseph Alan, In PLoS ONE, 1994
... Bcl-2 antibody (clone 124) was from DAKO (Carpinteria, CA, USA) and ...
Gelsolin displaces phalloidin from actin filaments. A new fluorescence method shows that both Ca2+ and Mg2+ affect the rate at which gelsolin severs F-actin
French John E. et al., In Cell research, 1993
... BCL2 cDNA (Accession: NM__00063, OriGene Technologies) into the Not ...
The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors
Nussenzweig Michel C. et al., In The Journal of Experimental Medicine, 1991
... , mIgμ, and Bcl-2 transgenic strains have been previously ...
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
Park Hye-Jin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1990
... Anti-Cdc25c (Cell Signaling Technology Inc., Danvers, MA), anticyclin B1 (Cell Signaling Technology Inc., Danvers, MA), anti-Bcl2 (Cell Signaling Technology Inc., Danvers, MA), ...
Expression of different CD8 isoforms on distinct human lymphocyte subpopulations
Spits Hergen et al., In The Journal of Experimental Medicine, 1990
... Cytoplasmic staining with FITC-conjugated anti–Bcl-2 mAb (clone 124; DAKO A/S, Glostrup, Denmark) was ...
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
Hendriks Rudolf W. et al., In The Journal of Experimental Medicine, 1990
... -2-22 Bcl-2 transgenic mice ...
Electrophoresis transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
John Annie et al., In International Journal of Molecular Sciences, 1978
... Polyclonal antibodies against beta-actin, Tom-40, NF-κB, iNOS and Bcl-2 were purchased from Santa Cruz Biotechnology Inc ...
Methodologic studies of the quantitative microdetermination of ATP in biological materials with the firefly enzyme system.
Häcker Georg, In PLoS ONE, 1966
... Anti BAD and anti Bcl-2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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