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Methylphosphate capping enzyme

BCDIN3, 7SK snRNA methylphosphate capping enzyme, MEPCE
Top mentioned proteins: POLYMERASE, PTER, ERM, LARP7, FTO
Papers on BCDIN3
Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults.
Canizales-Quinteros et al., Mexico. In Plos One, 2012
METHODS: 9 SNPs in biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), and 17 SNPs in or near genes associated with obesity in first, second and third wave GWAS (INSIG2, FTO, MC4R, TMEM18, FAIM2/BCDIN3, BDNF, SH2B1, GNPDA2, NEGR1, KCTD15, SEC16B/RASAL2, NPC1, SFRF10/ETV5, MAF, PRL, MTCH2, and PTER) were genotyped in 1,156 unrelated Mexican-Mestizos including 683 cases (441 obese class I/II and 242 obese class III) and 473 normal-weight controls.
The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation.
Hanes et al., Syracuse, United States. In Wiley Interdiscip Rev Rna, 2012
The mammalian ortholog of Bin3 (BCDIN3), also known as methyl phosphate capping enzyme (MePCE), plays a key role in repressing transcription.
Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology.
Seeley et al., Cincinnati, United States. In Obesity (silver Spring), 2012
In adipose tissue of rats fed on HFD, the mRNA levels of BCDIN3, KCTD15, and SULT1A1 were down-regulated, whereas those of MTCH2, PTER, and TUFM were up-regulated.
The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo.
Hanes et al., Albany, United States. In Dev Biol, 2011
In human cells, a Bin3 ortholog (BCDIN3) methylates the 5' end of 7SK RNA, but its role in vivo is unknown.
7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.
Peterlin et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2009
Here, we report that LARP7, BCDIN3, and the noncoding 7SK small nuclear RNA (7SK) are vital for the formation and stability of a cell stress-resistant core 7SK snRNP.
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.
Price et al., Iowa City, United States. In Nucleic Acids Res, 2008
A recent proteomics survey revealed that P-TEFb and the HEXIMs are tightly connected to two previously-uncharacterized proteins, the methyphosphate capping enzyme, MEPCE, and a La-related protein, LARP7.
Human capping enzyme promotes formation of transcriptional R loops in vitro.
Manley et al., New York City, United States. In Proc Natl Acad Sci U S A, 2007
Capping enzyme can play a direct role in transcription by modulating displacement of nascent RNA during transcription.
Transcriptional networking cap-tures the 7SK RNA 5'-gamma-methyltransferase.
Shuman, New York City, United States. In Mol Cell, 2007
In a recent issue of Molecular Cell, Jeronimo et al. (2007) identify BCDIN3, a Cdk9-associated protein, as the enzyme that forms the distinctive gamma-methylphosphate cap structure of 7SK, a noncoding RNA that regulates Cdk9 activity.
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Coulombe et al., Montréal, Canada. In Mol Cell, 2007
BCDIN3 is the 7SK snRNA methylphosphate capping enzyme (MePCE) present in an snRNP complex containing both RNA processing and transcription factors, including the elongation factor P-TEFb.
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