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Breast carcinoma amplified sequence 3

BCAS3, Rudhira, breast carcinoma amplified sequence 3
Top mentioned proteins: BCAS4, HAD, PIP5KIalpha, Estrogen Receptor, Serum albumin
Papers on BCAS3
Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology.
Hammond et al., Rotterdam, Netherlands. In Genet Epidemiol, Mar 2015
We identified 10 new loci associated with disc area (CDC42BPA, F5, DIRC3, RARB, ABI3BP, DCAF4L2, ELP4, TMTC2, NR2F2, and HORMAD2) and another 10 new loci associated with cup area (DHRS3, TRIB2, EFEMP1, FLNB, FAM101, DDHD1, ASB7, KPNB1, BCAS3, and TRIOBP).
Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.
Shi et al., Qingdao, China. In Nat Commun, 2014
(rs11653176, P=1.36 × 10(-13), BCAS3), 9p24.2 (rs12236871, P=1.48 × 10(-10), RFX3) and 11p15.5 (rs179785, P=1.28 × 10(-8), KCNQ1), which contain inflammatory candidate genes.
Generalization of associations of kidney-related genetic loci to American Indians.
Cole et al., Hyattsville, United States. In Clin J Am Soc Nephrol, 2014
An intronic variant of BCAS3 was significantly associated with urinary albumin to creatinine ratio.
Detecting and visualizing gene fusions.
Seifert et al., München, Germany. In Methods, 2013
We discuss several gene fusion events, like BCAS3-BCAS4 that was only detected in the breast cancer cell line MCF7.
Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis.
Inamdar et al., Bengaluru, India. In Exp Cell Res, 2012
Rudhira/BCAS3 (Breast Cancer Amplified Sequence 3) is a conserved protein expressed in the embryonic vasculature and malignant tumors.
Genome wide analysis reveals association of a FTO gene variant with epigenetic changes.
Schiöth et al., Uppsala, Sweden. In Genomics, 2012
We identified sites associated with the genes KARS, TERF2IP, DEXI, MSI1, STON1 and BCAS3 that had a significant differential methylation level in the carriers of the FTO risk allele (rs9939609).
Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.
Guillouzo et al., Rennes, France. In Toxicol Appl Pharmacol, 2012
Although they exhibited large variable inter-donor fold-changes, several of these genes, particularly FHIT, BCAS3 and SMYD3, were found to be altered by various direct and other indirect genotoxic compounds and unaffected by non-genotoxic compounds.
Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes.
Edwards et al., Cambridge, United Kingdom. In Bmc Genomics, 2011
From this analysis we identified 9 expressed fusion genes: APPBP2-PHF20L1, BCAS3-HOXB9, COL14A1-SKAP1, TAOK1-PCGF2, TIAM1-NRIP1, TIMM23-ARHGAP32, TRPS1-LASP1, USP32-CCDC49 and ZMYM4-OPRD1.
A de novo 3.54 Mb deletion of 17q22-q23.1 associated with hydrocephalus: a case report and review of literature.
Bhandari et al., New Haven, United States. In Am J Med Genet A, 2011
We describe a female newborn with a de novo 3.54 megabase (Mb) deletion of 17q22-q23.1 (chr17:53,072,536-56,612,662, hg18) including genes from MSI2 to BCAS3 detected by oligonucleotide array comparative genomic hybridization (aCGH).
Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.
Fox et al., Boston, United States. In Plos Genet, 2011
Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3).
Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia.
Delfino et al., Perugia, Italy. In J Chemother, 2011
Real-time PCR validated that up-regulation of sulphiredoxin 1 homolog (SRXN1), hemeoxygenase 1 (HMOX1), and breast carcinoma amplified sequence 3 (BCAS3) were consistently modulated.
Fusion gene microarray reveals cancer type-specificity among fusion genes.
Skotheim et al., Oslo, Norway. In Genes Chromosomes Cancer, 2011
Two additional fusion genes, BCAS4-BCAS3 in the MCF-7 breast cancer cell line and CCDC6-RET in the TPC-1 thyroid cancer cell line were validated as true positive fusion transcripts.
New loci associated with kidney function and chronic kidney disease.
Fox et al., Baltimore, United States. In Nat Genet, 2010
Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
Gene expression analysis in post-embryonic pericardial cells of Drosophila.
Inamdar et al., Bengaluru, India. In Gene Expr Patterns, 2008
Vertebrate Rudhira, an evolutionary conserved WD40 protein is expressed during primitive erythropoiesis, neoangiogenesis and tumors.
Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).
Kumar et al., Houston, United States. In Mol Endocrinol, 2007
Physically associated with histone H3 and histone acetyltransferase complex protein P/CAF (p300/CBP-associated factor) and possesses histone acetyltransferase activity.
Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis.
Inamdar et al., Bengaluru, India. In Plos One, 2006
BCAS3 is mis-expressed in brain tumors and could serve as a human ES cell and tumor marker
Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer.
Kumar et al., Houston, United States. In Cell Cycle, 2006
BCAS3 overexpression in hormone receptor-positive premenopausal breast cancer seemed to be associated with impaired responses to tamoxifen
MTA1, a transcriptional activator of breast cancer amplified sequence 3.
Kumar et al., Houston, United States. In Proc Natl Acad Sci U S A, 2006
role for MTA1-BCAS3 pathway in promoting cancerous phenotypes in breast tumor cells
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