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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Basal cell adhesion molecule

BCAM, Lutheran blood group glycoprotein, Lutheran antigen, L-U
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, CaM, CAN, V1a, HAD
Papers on BCAM
[Vascular myeloproliferative neoplasm with normal cell blood count: Exploration and medical management].
Priollet et al., Paris, France. In J Mal Vasc, Dec 2015
These experimental assays are promising for the development of new therapeutics in MPN; they assess red cell adherence to the vascular endothelium after the phosphorylation of Lu/BCAM subsequent to a positive JAK2V617F mutation.
Identification of miR-199a-5p target genes in the skin keratinocyte and their expression in cutaneous squamous cell carcinoma.
Yoon et al., Seoul, South Korea. In J Dermatol Sci, Aug 2015
RESULTS: We identified new target genes, Bcam, Fzd6, and Wnt7a, as well as previously known targets, Ddr1 and Podxl.
Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma.
Yen et al., Houston, United States. In Proc Natl Acad Sci U S A, Apr 2015
Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and AKT2, a key kinase in the PI3K signaling pathway.
Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology.
El Nemer et al., Paris, France. In Ebiomedicine, Feb 2015
Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density.
Novel receptors for bacterial protein toxins.
Aktories et al., Freiburg, Germany. In Curr Opin Microbiol, Feb 2015
Using optimized protocols and new methods novel toxin receptors have been identified, including metalloprotease ADAM 10 for Staphylococcus aureus α-toxin, laminin receptor Lu/BCAM for Escherichia coli cytotoxic necrotizing factor CNF1, lipolysis stimulated lipoprotein receptor (LSR) for Clostridium difficile transferase CDT and low-density lipoprotein receptor-related protein (LRP) 1 for Clostridium perfringens TpeL toxin.
Single-cell force spectroscopy as a technique to quantify human red blood cell adhesion to subendothelial laminin.
Lykotrafitis et al., United States. In J Biomech, 2015
In particular, RBCs adhere with high affinity to subendothelial matrix laminin via the basal cell adhesion molecule and Lutheran protein (BCAM/Lu).
Breast cancer prognostic biomarker using attractor metagenes and the FGD3-SUSD3 metagene.
Anastassiou et al., New York City, United States. In Cancer Epidemiol Biomarkers Prev, 2014
RESULTS: The resulting test, called BCAM (Breast Cancer Attractor Metagenes), is universally applicable to all clinical subtypes and stages of breast cancer and does not make any use of breast cancer molecular subtype or hormonal status information, none of which provided additional prognostic value.
Soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511 in vitro.
Mitaka et al., Hachiōji, Japan. In Exp Cell Res, 2014
Lutheran (Lu), an immunoglobulin superfamily transmembrane receptor, is also known as basal cell adhesion molecule (B-CAM).
Improved awareness, better screening needed to identify delirium patients who present to the ED.
In Ed Manag, 2014
Patients who are not ruled out by the DTS then undergo a more formal Brief Confusion Assessment Method or B-CAM, a tool that is a modified form of the CAM-ICU.
Systematically defining single-gene determinants of response to neoadjuvant chemotherapy reveals specific biomarkers.
Knudsen et al., Dallas, United States. In Clin Cancer Res, 2014
In particular, the nuclear oncogene DEK was strongly associated with pCR, whereas the cell surface protein BCAM was strongly associated with residual disease.
Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation.
El Nemer et al., Paris, France. In J Biol Chem, 2014
We have shown previously that young sickle reticulocytes adhere to resting endothelial cells through the interaction of α4β1 integrin with endothelial Lutheran/basal cell adhesion molecule (Lu/BCAM).
AKAP-dependent modulation of BCAM/Lu adhesion on normal and sickle cell disease RBCs revealed by force nanoscopy.
Lykotrafitis et al., Farmington, United States. In Biophys J, 2014
Human normal and sickle red blood cells (RBCs) adhere with high affinity to the alpha5 chain of laminin (LAMA5) via the basal cell adhesion molecule/Lutheran (BCAM/Lu) receptor, which is implicated in vasoocclusive episodes in sickle cell disease and activated through the cyclic adenosine monophosphate (cAMP) signaling pathway.
Molecular basis of erythrocyte adhesion to endothelial cells in diseases.
Wautier et al., Paris, France. In Clin Hemorheol Microcirc, 2012
Several molecules were shown to be involved in this phenomenon: VCAM-1, α4β1, Lu/BCAM, ICAM-4.
Epinephrine modulates BCAM/Lu and ICAM-4 expression on the sickle cell trait red blood cell membrane.
Lykotrafitis et al., United States. In Biophys J, 2012
Increases in adhesion frequency provide significant evidence of the role of epinephrine in BCAM/Lu-laminin and ICAM-4-alpha(v)beta(3) bonding, and suggest mechanisms of vaso-occlusion during physical exertion in sickle cell trait.
[Molecular basis of red blood cell adhesion to endothelium].
Wautier et al., Paris, France. In Ann Pharm Fr, 2011
This mutation stimulates erythropoiesis and is the cause of Lu/BCAM (CD239) phosphorylation, which potentiated the interaction with laminin alpha 5.
An antibody to the lutheran glycoprotein (Lu) recognizing the LU4 blood type variant inhibits cell adhesion to laminin α5.
Nomizu et al., Tokyo, Japan. In Plos One, 2010
Data indicate that the function-blocking antibody against Lu/B-CAM should be useful for not only investigating cell adhesion to laminin alpha5 but also for developing drugs to inhibit sickle cell vaso-occlusion.
Aggregation of mononuclear and red blood cells through an {alpha}4{beta}1-Lu/basal cell adhesion molecule interaction in sickle cell disease.
El Nemer et al., Paris, France. In Haematologica, 2010
Aggregation of mononuclear and red blood cells through an {alpha}4{beta}1-Lu/basal cell adhesion molecule interaction in sickle cell disease
Role of Lu/BCAM glycoproteins in red cell diseases.
Le Van Kim et al., Paris, France. In Transfus Clin Biol, 2010
BCAM glycoproteins are the unique erythroid receptors of laminin alpha5 chain, a major component of the extracellular matrix and are involved in several erythrocyte diseases.
The Lutheran glycoprotein: a multifunctional adhesion receptor.
Telen et al., Durham, United States. In Transfusion, 2006
B-CAM spliceoform seems to be overexpressed by a variety of different malignant tumors and may be involved, along with other adhesion receptor proteins, in malignant transformation and tumor metastasis. (review)
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