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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Basic leucine zipper transcription factor, ATF-like

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AP-1, MUM1, CD4, GDNF, CAN
Papers using BATF antibodies
Identifying DNA and protein patterns with statistically significant alignments of multiple sequences
Murphy Kenneth M. et al., In Nature, 1998
... BATF transgenic mice reveal a role for ...
Papers on BATF
A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control.
Cui et al., Milwaukee, United States. In Cell Rep, Dec 2015
We demonstrate that IL-21 causes a phenotypic switch of transcription factor expression in CD8 T cells during chronic viral infection characterized by sustained BATF expression.
Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.
Höpken et al., Berlin, Germany. In Faseb J, Nov 2015
Based on the observed high Irf4 and Batf gene expression, we suggest that CD4(+) T-cell transcription factors other than RORγt can cooperatively induce differentiation of IL-17-producing Th cells, including Th17-like Tfh-cell subsets.
Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226.
Park et al., Seoul, South Korea. In Immune Netw, Oct 2015
CD99 was highly expressed and the CD99 engagement led to activation of the MAP kinases, but suppressed AP-1 activity by inducing the expression of basic leucine zipper transcription factor, ATF-like (BATF), a negative regulator of AP-1 in RPMI8226 cells.
[B Cell Activating Transcription Factor Regulates Acute Airway Inflammation in Asthmatic Mice].
He et al., In Sichuan Da Xue Xue Bao Yi Xue Ban, Jul 2015
OBJECTIVE: To investigate the regulatory effect of B cell activating transcription factor (BATF) on acute airway inflammation and its association with retinoic acid orphan nuclear receptors gammat (RORyt) in asthmatic mice.
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.
Kallies et al., Australia. In Nat Immunol, Mar 2015
Furthermore, the transcriptional regulators BATF and IRF4 were necessary for VAT-Treg differentiation through direct regulation of ST2 and PPAR-γ expression.
Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12.
Carson et al., Columbus, United States. In Bmc Med Genomics, 2014
Network analyses identified a novel set of connected key players, BATF, IRF4, TBX21, and IFNG, within an integrated network composed of differentially expressed genes in NK cells stimulated by various conditions (immobilized IgG, IL-12, or the combination of IgG and IL-12).
The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.
Haining et al., Philadelphia, United States. In Nat Immunol, 2014
The transcription factor BATF is required for the differentiation of interleukin 17 (IL-17)-producing helper T cells (TH17 cells) and follicular helper T cells (TFH cells).
Hematopoietic stem cell injury induced by ionizing radiation.
Zhou et al., Little Rock, United States. In Antioxid Redox Signal, 2014
The mechanisms include (i) induction of HSC apoptosis via the p53-Puma pathway; (ii) promotion of HSC differentiation via the activation of the G-CSF/Stat3/BATF-dependent differentiation checkpoint; (iii) induction of HSC senescence via the ROS-p38 pathway; and (iv) damage to the HSC niche.
Physicochemical Characteristics of Beef Jerky Cured with Salted-fermented Anchovy and Shrimp.
Yang et al., Ch'angwŏn, South Korea. In Korean J Food Sci Anim Resour, 2013
Among the treatment samples, springiness was the highest in SFA2 and SFS2 (p<0.05) and the lowest values of Warner-Bratzler shear force were found in SFA1 and SFA2 (p<0.05).
Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks.
Murphy et al., Saint Louis, United States. In Nat Rev Immunol, 2013
Basic leucine zipper transcription factor ATF-like (BATF), BATF2 and BATF3 belong to the activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular processes.
Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4.
Sciammas et al., Chicago, United States. In Immunity, 2013
IRF4 cobound with the transcription factors PU.1 or BATF to Ets or AP-1 composite motifs, associated with genes involved in B cell activation and the GC response.
Transcriptional regulation of follicular T-helper (Tfh) cells.
Dong et al., Houston, United States. In Immunol Rev, 2013
Tfh cell differentiation results from a network of transcriptional regulation by a master transcriptional factor Bcl6 as well as IRF4, c-Maf, Batf, and STAT3/5.
Transcriptional control of dendritic cell development.
Murphy, Saint Louis, United States. In Adv Immunol, 2012
Currently, the basis for DC development into the recognized subsets/lineages is only partially understood, based on the requirements for several transcription factors including PU.1, Bcl11a, Irf8, E2-2, Id2, Irf4, Irf8, Batf3, and other BATF family members.
Molecular signatures of T-cell inhibition in HIV-1 infection.
Kamarulzaman et al., Linköping, Sweden. In Retrovirology, 2012
We also highlight the ensemble of transcriptional factors such as BATF, BLIMP-1/PRDM1, FoxP3, DTX1 and molecular pathways that facilitate the recruitment and differentiation of suppressor T cells in response to HIV infection.
The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.
Wang et al., United Kingdom. In Immunity, 2012
We discovered that Egr2 and/or Egr3 directly induced expression of suppressor of cytokine signaling-1 (SOCS1) and SOCS3, inhibitors of STAT1 and STAT3, and also blocked the function of Batf, an AP-1 inhibitor, in B and T cells.
Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression.
Iwai et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2011
BATF, together with c-Jun, transcriptionally inhibited expression of the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase Sirt1
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.
Murphy et al., Saint Louis, United States. In Nat Immunol, 2011
Data show that BATF functions at multiple hierarchical levels in two cell types to globally regulate switched antibody responses in vivo.
Batf promotes growth arrest and terminal differentiation of mouse myeloid leukemia cells.
Taparowsky et al., West Lafayette, United States. In Mol Cancer Res, 2011
Batf mediates the differentiation-inducing effects of Stat3 signaling in M1 cells and suggest that Batf may play a similar role in other blood cell lineages where alterations to the Jak-Stat pathway are hallmarks of disrupted development and disease.
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Haining et al., Boston, United States. In Nat Med, 2010
PD-1 inhibits T cell function by upregulating BATF.
Batf coordinates multiple aspects of B and T cell function required for normal antibody responses.
Taparowsky et al., West Lafayette, United States. In J Exp Med, 2010
Loss of Batf disrupts multiple components of the lymphocyte communication network that are required for a robust immune response.
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