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Basonuclin 1

basonuclin, BNC, basonuclin 1
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, POLYMERASE
Papers on basonuclin
Mechanism of Oxygen Reduction in Cytochrome c Oxidase and the Role of the Active Site Tyrosine.
Blomberg, Stockholm, Sweden. In Biochemistry, Feb 2016
Apart from the heme-copper binuclear center, there is a conserved tyrosine residue in the active site (BNC).
Realizing diverse electronic and magnetic properties in hybrid zigzag BNC nanoribbons via hydrogenation.
Chen et al., Changchun, China. In Phys Chem Chem Phys, Jan 2016
By means of first-principles DFT computations, we systematically investigate the geometries, stabilities, electronic and magnetic properties of fully and partially hydrogenated zigzag BNC nanoribbons (fH-zBNCNRs and pH-zBNCNRs) with interfacial N-C or B-C connections.
Identification of key active constituents of Buchang Naoxintong capsules with therapeutic effects against ischemic stroke by using an integrative pharmacology-based approach.
Hongjun et al., Beijing, China. In Mol Biosyst, Jan 2016
Integrative pharmacology has been used to identify the key active constituents (KACs) of Buchang Naoxintong capsules (BNCs), a traditional Chinese medical preparation; this approach involves the evaluation of the content profiles and drug-like properties of the BNC constituents and development of an ingredient-target network.
Development of a virus-mimicking nanocarrier for drug delivery systems: The bio-nanocapsule.
Kuroda et al., Ōsaka, Japan. In Adv Drug Deliv Rev, Jan 2016
To achieve biomimicry of the hepatitis B virus (HBV), we generated the "bio-nanocapsule" (BNC)-which deploys the human hepatocyte-targeting domain, fusogenic domain, and polymerized-albumin receptor domain of HBV envelope L protein on its surface-by overexpressing the L protein in yeast cells.
Intracellular trafficking of bio-nanocapsule-liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein.
Kuroda et al., Nagoya, Japan. In J Control Release, Sep 2015
Since BNCs could form a complex with an LP containing various drugs and genes, BNC-LP complexes have been used as a human hepatic cell-specific drug and gene-delivery system in vitro and in vivo.
A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis.
Ikegawa et al., Tokyo, Japan. In Am J Hum Genet, Sep 2015
The most significantly associated SNPs were in intron 3 of BNC2, which encodes a zinc finger transcription factor, basonuclin-2.
Programmable bio-nanochip-based cytologic testing of oral potentially malignant disorders in Fanconi anemia.
Vigneswaran et al., Houston, United States. In Oral Dis, Jul 2015
In an ongoing clinical trial, we are evaluating the effectiveness of the programmable bio-nanochip (p-BNC)-based oral cytology test in diagnosing oral potentially malignant disorders (OPMD) in non-FA patients.
Immunologic Overlap of Helper T-Cell Subtypes 17 and 22 in Erythrodermic Psoriasis and Atopic Dermatitis.
Nazarian et al., Boston, United States. In Jama Dermatol, Jul 2015
We evaluated immunohistochemical stains for CD3 and dual stains for CD4 and T-bet, GATA binding protein 3 (GATA3), signal transducer and activator of transcription 3 (STAT3), or basonuclin 2 (BNC2), which are transcription factors reported to be specific and mutually exclusive for TH1, TH2, TH17, and TH22 cells, respectively.
Metal-free ferromagnetic metal and intrinsic spin semiconductor: two different kinds of SWCNT functionalized BN nanoribbons.
Lou, Hefei, China. In Phys Chem Chem Phys, Apr 2015
Thus, (m,m)SWCNT functionalization of n-ZBNNRs may open new routes toward practical nanoelectronic and optoelectronic as well as spintronic devices based on BNC-based materials.
The binucleate cell of okapi and giraffe placenta shows distinctive glycosylation compared with other ruminants: a lectin histochemical study.
Allen et al., San Diego, United States. In Mol Phylogenet Evol, Feb 2015
The placenta of ruminants contains characteristic binucleate cells (BNC) with a highly conserved glycan structure which evolved early in Ruminant phylogenesis.
A modularity-based method reveals mixed modules from chemical-gene heterogeneous network.
Lu et al., Beijing, China. In Plos One, 2014
In the end, MixMod was applied to the 2-HN of Buchang naoxintong capsule (BNC) and detected 49 mixed modules.
BNC1 is required for maintaining mouse spermatogenesis.
Tseng et al., Philadelphia, United States. In Genesis, 2012
BNC1 is required for the maintenance of spermatogenesis.
p63 Transcriptionally regulates BNC1, a Pol I and Pol II transcription factor that regulates ribosomal biogenesis and epithelial differentiation.
Nylander et al., Umeå, Sweden. In Eur J Cancer, 2012
p63 induces the expression of the basal epithelial transcription factor, Basonuclin 1.
[Basonuclins and DISCO proteins: regulators of development in vertebrates and insects].
Djian et al., Paris, France. In Med Sci (paris), 2012
It remains to be found which targets are common to the two basonuclins and even to the DISCO proteins, and why certain cell types possess either basonuclin 1 or basonuclin 2, while others possess both.
Basonuclins and disco: Orthologous zinc finger proteins essential for development in vertebrates and arthropods.
Djian et al., Paris, France. In Biochimie, 2011
Basonuclin 1 and the recently discovered basonuclin 2 are vertebrate proteins with multiple paired C(2)H(2) zinc fingers.
[Bio-nanocapsules for in vivo pinpoint drug delivery].
Kuroda et al., Ibaraki, Japan. In Yakugaku Zasshi, 2007
Bio-nanocapsule (BNC) is recombinant yeast-derived hepatitis B virus surface antigen particle, which has been used as a recombinant hepatitis B vaccine for the last 20 years in the world.
Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium.
Tseng et al., Philadelphia, United States. In Plos One, 2006
Basonuclin likely coordinates functions of a subset of ribosomal RNA genes (rDNA) and a group of protein coding genes in cellular processes critical for the regulation of cell proliferation
Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.
Djian et al., Paris, France. In Proc Natl Acad Sci U S A, 2006
Data show that basonuclin (Bn)2 but not bn1 colocalizes with SC35 in nuclear speckles, and may have a function in nuclear processing of mRNA.
Re-epithelialisation and the possible involvement of the transcription factor, basonuclin.
Kumagai et al., Kawasaki, Japan. In Int Wound J, 2004
This article briefly summarises the basic mechanism of re-epithelialisation and discusses the possible role of the cell-type-specific transcription factor, basonuclin.
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