Fritzsch et al., Iowa City, United States. In Dev Dyn, 2013
The late-onset hair cell death in the absence of early N-Myc expression could be due to mis-regulation of genes necessary for neurosensory formation and maintenance, such as Neurod1, Atoh1, Pou4f3, and Barhl1.
Fritzsch et al., Iowa City, United States. In Brain Res, 2012
Previous studies have shown that the deletion of Atoh1 results in embryonic loss of hair cells while the absence of Barhl1, Gfi1, and Pou4f3 leads to the progressive loss of hair cells in newborn mice.
Gan et al., Rochester, United States. In Proc Natl Acad Sci U S A, 2012
Here, we show that a single transcription factor (TF), BARHL2, regulates this choice in proprioceptive dI1 interneurons by selectively suppressing cardinal dI1contra features in dI1ipsi neurons, despite expression by both subtypes.
Fritzsch et al., Iowa City, United States. In Plos One, 2011
Gene expression analyses of Atoh1, Barhl1 and Pou4f3, genes required for survival and maturation of hair cells, reveal earlier and higher expression levels in the inner compared to the outer hair cells.
Wade et al., Ottawa, Canada. In Biochem Biophys Res Commun, 2011
Given the important role of Barhl1 in brain development, it was proposed that perturbations of thyroid hormone -mediated transcriptional control of Barhl1 may play a role in the impaired neurodevelopment induced by hypothyroidism.
These genes received the name of BarH due to the Drosophila "Bar" mutant phenotype and, since then, vertebrate homologues (named BarH-like or Barhl) have been described in a number of species of fish, amphibians and mammals.