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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

BarH-like 2

BarH1, Barhl2, Mbh1, BarH
potential regulator of mammalian neural bHLH genes [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Barhl1, beta 2-adrenoceptor, FATE, CAN, Otx2
Papers on BarH1
A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.
Volkan et al., Durham, United States. In Plos Genet, Jan 2016
Here, we show that Rn, along with BarH1/H2 (Bar), Bric-à-brac (Bab), Apterous (Ap) and Dachshund (Dac), constitutes a transcription factor (TF) network that patterns the developing olfactory tissue.
Functional enrichment analysis of three Alzheimer's disease genome-wide association studies identities DAB1 as a novel candidate liability/protective gene.
Saffen et al., Taiwan. In Biochem Biophys Res Commun, Sep 2015
Ten of these genes, have previously been identified as candidate AD liability genes in genetic association studies (AGT, COL11A1) or encode proteins that function in biological systems or pathways previously implicated in AD (BARHL2, CSF3R, DAB1, HMCN1, LEPR, PTPRF, PXDN, TNR).
Early development of the neural plate: new roles for apoptosis and for one of its main effectors caspase-3.
Durand et al., New York City, United States. In Genesis, Feb 2015
The BarH-like (Barhl) proteins are homeodomain-containing transcription factors.
The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog.
Durand et al., Paris, France. In Dev Biol, 2015
Using loss- and gain-of-function, explants and grafting experiments in amphibians, we demonstrate that barhl2 acts downstream of otx2 and together with the iroquois (irx)-3 gene in establishment of the ZLI compartment initiated by Shh influence.
Bar represses dPax2 and decapentaplegic to regulate cell fate and morphogenetic cell death in Drosophila eye.
Choi et al., Taejŏn, South Korea. In Plos One, 2013
Here we present evidence that BarH1 and BarH2 homeobox genes are essential for eye patterning by inhibiting excess cone cell differentiation and promoting programmed death of IOM cells.
Differential and redundant functions of gooseberry and gooseberry neuro in the central nervous system and segmentation of the Drosophila embryo.
Noll et al., Zürich, Switzerland. In Dev Biol, 2013
Lineage analysis in the embryonic CNS showed that gsbn is expressed in the entire lineage derived from NB5-4, which generates 4 or 5 motoneurons whose axons are part of the SNa branch and all of which except one also express BarH1.
Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas.
Leung et al., West Lafayette, United States. In Gene Expr Patterns, 2013
This study reports an investigation of the regulatory role of irx7 on 13 genes including aanat2, barhl2, bhlhe22, cdh11, ckmt1, gnat1, irx4a, ndrg1a, nme2l, pbx1a, rcv1, robo2 and tfap2a.
Inducible gene expression in postmitotic neurons by an in vivo electroporation-based tetracycline system.
Saito et al., Chiba, Japan. In J Neurosci Methods, 2013
Moreover, the TRE-driven inducible expression of mammalian Barh1 (Mbh1) mimicked the phenotype of the ubiquitous expression of Mbh1 in the spinal cord.
Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2.
Poggi et al., Australia. In J Neurosci, 2012
We find evidences that the homeobox transcription factor Barhl2 is an AC subtype identity-biasing factor that turns on within Atoh7-positive descendants.
DNA methylation biomarkers for lung cancer.
Pfeifer et al., Duarte, United States. In Tumour Biol, 2012
Using sodium-bisulfite-based approaches, 12 CpG islands (associated with the BARHL2, EVX2, IRX2, MEIS1, MSX1, NR2E1, OC2, OSR1, OTX1, PAX6, TFAP2A, and ZNF577 genes) were confirmed to be methylated in 85% to 100% of the squamous cell carcinomas and 11 CpG islands (associated with the CHAD, DLX4, GRIK2, KCNG3, NR2E1, OSR1, OTX1, OTX2, PROX1, RUNX1, and VAX1 genes) were methylated in >80% of the adenocarcinomas.
BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord.
Gan et al., Rochester, United States. In Proc Natl Acad Sci U S A, 2012
results elucidate BARHL2 as a critical postmitotic regulator of dI1 subtype diversification, as well as its intermediate position in the dI1 genetic hierarchy
Barhl2 limits growth of the diencephalic primordium through Caspase3 inhibition of beta-catenin activation.
Durand et al., Paris, France. In Proc Natl Acad Sci U S A, 2011
in the developing diencephalon, Caspase3 acts downstream of Barhl2 in limiting neuroepithelial cell proliferation by inhibiting beta-catenin activation.
Quantitative real-time PCR with SYBR Green detection to assess gene duplication in insects: study of gene dosage in Drosophila melanogaster (Diptera) and in Ostrinia nubilalis (Lepidoptera).
Escriche et al., Burjassot, Spain. In Bmc Res Notes, 2010
The system was applied to determine the copy number of: (1) the O. nubilalis cadherin gene, involved in the mode of action of Bacillus thuringiensis toxins, which showed indirect evidence of duplication, and (2) the D. melanogaster BarH1 and BarH2 genes, located within the Bar region of the X chromosome, to clearly determine whether they both are covered by the tandem duplication in the classical Bar (B1) mutant.
Evolutionary relationships and diversification of barhl genes within retinal cell lineages.
Poggi et al., Heidelberg, Germany. In Bmc Evol Biol, 2010
In line with this hypothesis, we investigated the evolution of the homeobox Barhl family of transcription factors, barhl1 and barhl2, in the teleost and tetrapod lineages.
BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons.
Gan et al., Rochester, United States. In J Neurosci, 2009
BARHL2 plays roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival.
Differentially expressed genes identified by cross-species microarray in the blind cavefish Astyanax.
Jeffery et al., College Park, United States. In Integr Zool, 2009
The downregulated probe sets showing some of the highest fold changes corresponded to genes with roles in eye development, including those encoding gamma crystallins, the guanine nucleotide binding proteins Gnat1 and Gant2, a BarH-like homeodomain transcription factor, and rhodopsin.
Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation.
Saito et al., Chiba, Japan. In Dev Biol, 2008
Math1 directly regulates the Mbh genes in CGCs. Furthermore, a dominant-negative form of the Mbh proteins disrupted proper
Functions of BarH transcription factors during embryonic development.
Concha et al., Santiago, Chile. In Dev Biol, 2007
These genes received the name of BarH due to the Drosophila "Bar" mutant phenotype and, since then, vertebrate homologues (named BarH-like or Barhl) have been described in a number of species of fish, amphibians and mammals.
Expression of Drosophila BarH1-H2 homeoproteins in developing dopaminergic cells and segmental nerve a (SNa) motoneurons.
Carroll et al., Montpellier, France. In Eur J Neurosci, 2006
describe the restricted expression pattern of the B-H1 homeoprotein within the embryonic ventral nerve cord of Drosophila
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