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NEDD4 binding protein 2

B3BP, BCL-3-binding protein, Nedd4-binding protein 2
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bcl-3, p300, Phosphodiesterase, Nedd4, Histone
Papers on B3BP
Modulated nicking endonuclease function by the N-terminal extended region of the smr domain in human Bcl-3 binding protein.
Ban et al., South Korea. In Proteins, 2012
the N-terminal extended region of the Smr domain in the native B3bp may function as a regulatory region for the nicking endonuclease
Solution structure and characterization of the DNA-binding activity of the B3BP-Smr domain.
Folkers et al., Utrecht, Netherlands. In J Mol Biol, 2008
The solution structure of the functionally active Smr domain of the Bcl3-binding protein (also known as Nedd4-binding protein 2), a protein with unknown function that lacks other domains present in MutS proteins, is determined.
Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population.
Zeng et al., Guangzhou, China. In J Transl Med, 2006
These data suggest that haplotype blocks ATTA and GTTG of N4BP2 is correlation with the risk of sporadic nasopharyngeal carcinoma in the Southern Chinese population.
Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.
Fujita et al., Tokyo, Japan. In J Biol Chem, 2003
B3BP is a 5'-polynucleotide kinase
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