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Aurora kinase C

Aurora-C, AURC, AURKC, Aie1, STK13
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Aurora, Aura, CAN, Histone, HAD
Papers using Aurora-C antibodies
Update on Aurora kinase targeted therapeutics in oncology
Ulisse Salvatore et al., In BMC Cancer, 2010
... polyclonal anti-Aurora-C antibody was generated against a 16 amino acid peptide of the C-terminal part of Aurora-C (aa 259-275) by Eurogentec (Seraing, Belgium) ...
Aurora-C kinase supports mitotic progression in the absence of Aurora-B.
Vanacker Jean-Marc, In PLoS ONE, 2008
... Human Aurora-C cDNA was obtained from pET21b-Aurora-C (Dutertre et al., 2005) and inserted into peEGFP-C3 plasmid (Clontech).
Papers on Aurora-C
Macrozoospermia: screening for the homozygous c.144delC mutation in AURKC gene in infertile men and estimation of its heterozygosity frequency in the Tunisian population.
Ibala-Romdhane et al., Sousse, Tunisia. In J Assist Reprod Genet, Nov 2015
The homozygous mutation (c.144delC) in aurora kinase C gene (AURKC) has been identified as the most frequent mutation causing macrozoospermia in North African patients.
Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model.
Yadav et al., Vadodara, India. In Mol Divers, Nov 2015
Aurora kinases are sub-divided into Aurora A, Aurora B, and Aurora C kinases that are considered as prospective targets for a new class of anticancer drugs.
Male infertility and its genetic causes.
Sengoku et al., Asahikawa, Japan. In J Obstet Gynaecol Res, Oct 2015
We discuss here the contribution to male factor infertility of a number of genes identified in the azoospermia factor (AZF) region on the Y chromosome, as well as the autosomally located genes: SYKP3, KLHL10, AURKC and SPATA16.
Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines.
Modarressi et al., Tehrān, Iran. In Tumour Biol, Sep 2015
In this context, we investigated the expression of two known cancer testis genes, Aurora kinase C (AURKC) and testis expressed 101 (TEX101), and one new candidate, deleted in azoospermia 1 (DAZ1), in six breast cancer cell lines including two ductal carcinomas, T47D and BT-474, and four adenocarcinomas, MDA-MB-231, MDA-MB-468, MCF7, and SKBR3 as well as 50 breast cancer tumors in comparison to normal mammary epithelial cells using quantitative real-time reverse transcription PCR (RT-PCR).
Regulation of AURKC expression by CpG island methylation in human cancer cells.
Sen et al., Kashiwa, Japan. In Tumour Biol, Sep 2015
AURKC, a member of the Aurora kinase gene family, is highly expressed in testis but is either moderately expressed or repressed in most somatic cells.
Expression and characterization of three Aurora kinase C splice variants found in human oocytes.
Schindler et al., United States. In Mol Hum Reprod, Aug 2015
Aurora kinase C (AURKC) is a component of the chromosome passenger complex and is highly expressed in gametes.
Teratozoospermia: spotlight on the main genetic actors in the human.
Ray et al., Grenoble, France. In Hum Reprod Update, Jul 2015
Homozygous mutations of aurora kinase C (AURKC) were first described to be responsible for most cases of macrozoospermia.
RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse.
Schindler et al., Al Manşūrah, Egypt. In Biol Reprod, Apr 2015
To our knowledge, these results are the first to identify RBBP4 as a regulator of histone deacetylation during oocyte maturation, and they provide evidence that deacetylation is required for bipolar spindle assembly through AURKC.
Comprehensive investigation in patients affected by sperm macrocephaly and globozoospermia.
Krausz et al., Florence, Italy. In Andrology, Mar 2015
AURKC was sequenced in case of sperm macrocephaly while the DPY19L2 status has been analyzed by multiple approaches including a novel qPCR-based copy number assay in case of globozoospermia.
Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.
Su Oh et al., Suwŏn, South Korea. In Sci Rep, 2014
Although Zwint-1 knockdown did not affect Aurora C kinase activity, the meiotic defects following Zwint-1 knockdown were similar to those observed with ZM447439 treatment.
Functions of Aurora kinase C in meiosis and cancer.
Schindler et al., United States. In Front Cell Dev Biol, 2014
The mammalian genome encodes three Aurora kinase protein family members: A, B, and C. While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body, significant protein levels of Aurora kinase C (AURKC) are limited to cells that undergo meiosis (sperm and oocyte).
Possible Role of Aurora-C in Meiosis.
Tang et al., Taipei, Taiwan. In Front Oncol, 2014
The Aurora kinases, which include Aurora-A, Aurora-B, and Aurora-C, are highly conserved serine-threonine kinases that play essential roles in centrosome function, chromosome segregation, and cytokinesis during mitosis and meiosis.
Aurora Kinase Inhibitors: Current Status and Outlook.
Linardopoulos et al., London, United Kingdom. In Front Oncol, 2014
In humans, the Aurora kinase family consists of three members; Aurora-A, Aurora-B, and Aurora-C, which each share a conserved C-terminal catalytic domain but differ in their sub-cellular localization, substrate specificity, and function during mitosis.
Expression Analysis of Aurora-C and Survivin, Two Testis-Specific Genes, in Patients with Colorectal Cancer.
Sakhinia et al., In Clin Lab, 2014
Cancer/testis (CT) antigens such as Aurora-C and Survivin are a group of antigens expressed in various tumor types of human cancers.
Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development.
Schultz et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2012
These findings suggest a model for the presence of AURKC in oocytes: that AURKC compensates for loss of AURKB through differences in both message recruitment and protein stability.
A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis.
Ray et al., Grenoble, France. In Mol Hum Reprod, 2011
Molecular analysis of the AURKC gene was carried out in two brothers presenting with a typical large-headed spermatozoa phenotype. Both affected brothers were heterozygous for the c.144delC mutation in the AURKC gene.
Aurora kinase-C-T191D is constitutively active mutant.
Khan et al., Dera Ismāīl Khān, Pakistan. In Bmc Cell Biol, 2011
Aurora C-T191D is not hyperactive but is constitutively active mutant.
Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells.
Hung et al., Zhengzhou, China. In J Pathol, 2011
we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells
Overexpression of active Aurora-C kinase results in cell transformation and tumour formation.
Prigent et al., Rennes, France. In Plos One, 2010
overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation; tumor aggressiveness was positively correlated with the quantity of active kinase
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.
Ray et al., Grenoble, France. In Nat Genet, 2007
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.
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