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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Aurora kinase A

Aura, Aurora-A, STK15
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Aurora, p53, CAN, V1a, HAD
Papers using Aura antibodies
Diffenretial expression of the components of the plaminogen actviating system in human thyroid tumor derived cell lines and papillary carcinomas
Arlot-Bonnemains Yannick et al., In Endocrine-Related Cancer, 2004
... The monoclonal anti-Aurora-A antibody (clone 35C1) was obtained from Abcam (Paris, France) ...
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly.
Abdelhay Eliana Saul Furquim Werneck, In PLoS ONE, 2002
... The Aurora-A kinase inhibitor III (Merck Calbiochem Inc ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Malumbres Marcos et al., In Frontiers in Oncology, 1997
... on 12.5% SDS polyacrylamide gels and submitted to western blot using the appropriated antibodies against Aurora-A (Abcam, mouse monoclonal 35C1 clone; ...
Papers on Aura
Identification and Visualization of Kinase-Specific Subpockets.
Fulle et al., In J Chem Inf Model, Feb 2016
The potential impact of the approach is demonstrated in four retrospective experiments on closely related kinases, i.e. p38α vs. Erk2, PAK1 vs. PAK4, ITK vs. AurA, and BRAF vs. VEGFR2.
Subcellular localization of EGFR in esophageal carcinoma cell lines.
Lassmann et al., Freiburg, Germany. In J Cell Commun Signal, Dec 2015
EGFR however also exhibits dynamic changes of subcellular localization, leading to STAT5 complex formation, nuclear translocation and induction of Aurora-A expression in squamous cancer cells.
Selective inhibitors of aurora kinases inhibit proliferation, reduce cell viability and impair cell cycle progression in papillary thyroid carcinoma cells.
Ulisse et al., Roma, Italy. In J Biol Regul Homeost Agents, Oct 2015
The three members of the Aurora kinase family, Aurora-A, -B and -C, regulate several aspects of the mitotic process, and their aberrant expression and/or function causes mitotic abnormalities leading either to cell death or aneuploidy.
GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.
Seemann et al., Dallas, United States. In Cell, Aug 2015
Sequestration of importin α by GM130 liberates the spindle assembly factor TPX2, which activates Aurora-A kinase and stimulates local microtubule nucleation.
Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis.
Sharma-Walia et al., North Chicago, United States. In Bmc Cancer, 2014
Gene copy numbers for oncogenic pathway regulators such AKT1, Aurora-A Kinase (AURKA or IAK-1), epidermal growth factor receptor (EGFR) and MYC with a reduction in the copy numbers of cyclin dependent kinase inhibitor 2A (CDKN2A), PTEN and DNA topoisomerase 2 alpha (TOP2A) were induced in presence of OPG.
Aurora-A Kinase as a Promising Therapeutic Target in Cancer.
Galanis et al., Rochester, United States. In Front Oncol, 2014
Among the three members of the Aurora kinase family (Aurora-A, -B, and -C), Aurora-A and Aurora-B are expressed at detectable levels in somatic cells undergoing mitotic cell division.
Aurora Kinase Inhibitors: Current Status and Outlook.
Linardopoulos et al., London, United Kingdom. In Front Oncol, 2014
In humans, the Aurora kinase family consists of three members; Aurora-A, Aurora-B, and Aurora-C, which each share a conserved C-terminal catalytic domain but differ in their sub-cellular localization, substrate specificity, and function during mitosis.
Role of Aurora-A in Ovarian Cancer: A Meta-Analysis.
You et al., Guangzhou, China. In Oncol Res Treat, 2014
BACKGROUND: Recently, several studies have examined associations between Aurora-A expression and clinical outcome in patients with ovarian cancer, but yielded conflicting results with respect to survival.
The Non-Canonical Role of Aurora-A in DNA Replication.
Kudo et al., Tokushima, Japan. In Front Oncol, 2014
Aurora-A is a well-known mitotic kinase that regulates mitotic entry, spindle formation, and chromosome maturation as a canonical role.
Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives.
Lallena et al., Alcobendas, Spain. In Front Oncol, 2014
Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins, such as Aurora-A and -B.
Cyclin B2 and p53 control proper timing of centrosome separation.
van Deursen et al., Rochester, United States. In Nat Cell Biol, 2014
Cyclins B1 and B2 both induce aneuploidy when overexpressed but through distinct mechanisms, with cyclin B1 inhibiting separase activation, leading to anaphase bridges, and cyclin B2 triggering aurora-A-mediated Plk1 hyperactivation, resulting in accelerated centrosome separation and lagging chromosomes.
AURA 2: Empowering discovery of post-transcriptional networks.
Quattrone et al., Trento, Italy. In Translation (austin), 2013
To address this issue, we developed the second and vastly enhanced version of the Atlas of UTR Regulatory Activity (AURA 2), a meta-database centered on mapping interaction of trans-factors with human and mouse UTRs.
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma.
Eilers et al., Würzburg, Germany. In Cancer Cell, 2013
N-Myc forms a complex with the Aurora-A kinase, which protects N-Myc from proteasomal degradation.
Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
Mizuno et al., Sendai, Japan. In J Biol Chem, 2012
Fry also binds to Aurora A and promotes Plk1 activity by binding to the polo-box domain of Plk1 and by facilitating Aurora A-mediated Plk1 phosphorylation at Thr-210.
Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.
Shimizu et al., Gifu, Japan. In Curr Cancer Drug Targets, 2012
Cyclin-dependent kinase/aurora kinase inhibitor JNJ-7706621 is a unique regulator of tumor cell cycle progression at multiple points.
Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells.
Cheng et al., Taiyuan, China. In Mol Cancer Res, 2012
these studies provide a molecular basis for promoting the role of Aurora-A in malignancy development of Esophageal squamous cell carcinoma
IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer.
Zhan et al., Beijing, China. In Biochem Biophys Res Commun, 2012
these results showed an unidentified relationship between Aurora-A and IQGAP1, and provided a new insight into the molecular mechanism by which IQGAP1 played a regulatory role in cancer.
LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
Shah et al., West Lafayette, United States. In J Cell Sci, 2012
Aurora A regulates LIMK2 kinase activity, subcellular localization and protein levels by direct phosphorylation at S283, T494 and T505.
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
Sen et al., Houston, United States. In Cancer Cell, 2012
Aurora-A phosphorylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic sequestration in a complex with the chaperon protein mortalin.
A MEK-independent role for CRAF in mitosis and tumor progression.
Cheresh et al., San Diego, United States. In Nat Med, 2011
Mechanistically, CRAF, but not BRAF, associates with Aurora kinase A (Aurora-A) and Polo-like kinase 1 (Plk1) at the centrosomes and spindle poles during G2/M.
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