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ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1

ATP6V1C1, ATP6C, ATP6V1C, V-ATPase c-subunit
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, V-ATPase, ACID, CAN, ATP6V0D2
Papers on ATP6V1C1
V-type ATPase proton pump expression during enamel formation.
Paine et al., Los Angeles, United States. In Matrix Biol, Dec 2015
Western blot analyses, using specific antibodies to four of the V-type ATPase subunits (Atp6v0d2, Atp6v1b2, Atp6v1c1 and Atp6v1e1), were then applied to validate much of the qPCR data.
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Vaira et al., Milano, Italy. In Oncotarget, Aug 2015
Despite few observations, the role of V-ATPase in human tumorigenesis remains unclear.We investigated the expression of ATP6V0C, ATP6V0A2, encoding two subunits belonging to the V-ATPase V0 sector and ATP6V1C, ATP6V1G1, ATPT6V1G2, ATP6V1G3, which are part of the V1 sector, in series of adult gliomas and in cancer stem cell-enriched neurospheres isolated from glioblastoma (GBM) patients.
Targeting Atp6v1c1 Prevents Inflammation and Bone Erosion Caused by Periodontitis and Reveals Its Critical Function in Osteoimmunology.
Chen et al., Birmingham, United States. In Plos One, 2014
In this study, we utilized novel adeno-associated virus (AAV)-mediated Atp6v1c1 knockdown gene therapy to treat bone erosion and inflammatory caused by periodontitis in mouse model.
Identification and characterization of a multispecific monoclonal antibody G2 against chicken prion protein.
Ishiguro et al., Gifu, Japan. In Protein Sci, 2014
We immunoscreened a complementary DNA library from chicken brain DNA and found three proteins (SEPT3, ATP6V1C1, and C6H10orf76) that reacts with G2.
Atp6v1c1 may regulate filament actin arrangement in breast cancer cells.
Deng et al., Shanghai, China. In Plos One, 2013
Our previous study showed that Atp6v1c1-depleted osteoclasts did not form organized actin rings and that Atp6v1c1 co-localizes with F-actin.
Transcriptome changes favoring intramuscular fat deposition in the longissimus muscle following castration of bulls.
Baik et al., Suwŏn, South Korea. In J Anim Sci, 2013
Correlation analysis indicated that the IMF content in the LM was highly correlated with mRNA levels of PLIN2 (r = 0.70, P < 0.001), adenosine triphosphatase (ATPase), H(+)-transporting, lysosomal 42 kDa, V1 subunit C1 (ATP6V1C1: r = 0.66, P < 0.001), and cytochrome c oxidase assembly homolog 11 (COX11: r = 0.72, P < 0.001) genes in a pooled animal group of steers plus bulls, and significant correlations in the steer-alone group were maintained in the 3 genes, PLIN2 (r = 0.47, P < 0.05), ATP6V1C1 (r = 0.50, P < 0.05), and COX11 (r = 0.60, P < 0.01).
A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients.
Zhang et al., Shanghai, China. In Genomics, 2013
A combination of SULF1, INTS8, ATP6V1C1, and GPR172A was identified with a prediction accuracy of 98.0% for discriminating carcinomas from adjacent noncancerous tissues in our previous 25 paired samples.
Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma.
Masoudi-Nejad et al., Tehrān, Iran. In Plos One, 2012
The genes EGFR, PIK3CA, TAF15, XIAP, VAPB, Appl1, Rab5a, ARF4, CLPTM1L, SP4, ZNF124, LPP, FOXP1, SOX18, MSX2, NFE2L2, SMARCC1, TRA2B, CBX3, PRPF6, ATP6V1C1, MYBBP1A, MACF1, GRM2, TBXA2R, PRKAR2A, PTK2, PGF and MYO10 are among the genes that belong to modules 1 and 22.
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
Aguirre-Urízar et al., Santiago de Compostela, Spain. In Biotech Histochem, 2012
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
An update in the structure, function, and regulation of V-ATPases: the role of the C subunit.
García-García et al., Santiago de Compostela, Spain. In Braz J Biol, 2012
The protein is encoded by the ATP6V1C gene and is located at position 22 of the long arm of chromosome 8 (8q22.3).
Neuron-specific expression of atp6v0c2 in zebrafish CNS.
Huh et al., Taegu, South Korea. In Dev Dyn, 2010
In the present study, we investigated the neuron-specific expression of atp6v0c2, a novel isoform of the V-ATPase c-subunit, during the development of the zebrafish CNS.
Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma.
García-García et al., Santiago de Compostela, Spain. In Cancer Biol Ther, 2010
ATP6V1C1, one of the main genes regulating V-ATPase activity, has been implicated in metastasis and multiple drug resistance.
Role of V-ATPases in solid tumors: importance of the subunit C (Review).
Gándara-Vila et al., Santiago de Compostela, Spain. In Int J Oncol, 2009
The C subunit (ATP6V1C) of V1 intra-membrane domain of the V-ATPase, is primarily responsible for its enzymatic function, through the control of a reversible dissociation of V0 and V1 domains.
Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.
Li et al., Linping, China. In Biochem J, 2009
Study demonstrates that Atp6v1c1 is an essential component of the osteoclast proton pump at the osteoclast ruffled border and that it may regulate F-actin ring formation in osteoclast activation.
Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene.
García-García et al., Santiago de Compostela, Spain. In Oral Oncol, 2008
ATP6V1C1 was the most strongly over-expressed gene in oral squamous cell carcinoma at the mRNA level compared to other genes of the V-ATPase complex.
Structural and functional characterization of two human V-ATPase subunit gene promoters.
Kohno et al., Kitakyūshū, Japan. In Biochim Biophys Acta, 2003
proximal promoter region contains cis-acting elements required for expression in cancer cells
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