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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ATG5 autophagy related 5 homolog

Atg5, Apg5
Top mentioned proteins: LC3, Atg7, V1a, Beclin 1, CAN
Papers using Atg5 antibodies
Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux
De Milito A et al., In Cell Death & Disease, 2008
... and phospho-4EBP1 (Cell Signaling Technology, Milano, Italy), p62 (BD Transduction Laboratories, Milano, Italy), Beclin-1 and Atg5 (Santa Cruz Biotechnology, USA), ...
The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores.
Blagosklonny Mikhail V., In PLoS ONE, 2006
... Anti-LC3B antibody was purchased from Novus Biologicals (Littleton, CO) and anti-BECN1 and anti-ATG5 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Cellular targets of gefitinib.
Zhang Lin, In PLoS ONE, 2004
... The Primary antibodies were antibodies against microtubule-associated protein 1 light chain 3 (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell ...
Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
Manié S N et al., In Cell Death & Disease, 2002
... International Corporation, Nanterre, France), anti-p53 (D0–7, DAKO), anti-Beclin (E-8, Santa-Cruz, Le perray en Yvelines, France), anti-ATG5 (D1G9, Cell Signaling, Montigny le Bretonneux, France), ...
Papers on Atg5
Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade.
Snyder et al., Baltimore, United States. In Proc Natl Acad Sci U S A, Feb 2016
Depletion of ATG5 or beclin-1, major mediators of autophagy, prevents cocaine-induced cell death.
Moderate stress responses and specific changes in polyamine metabolism characterize Scots pine somatic embryogenesis.
Vuosku et al., Oulu, Finland. In Tree Physiol, Feb 2016
Cellular PA contents and the expression of the PA metabolism genes arginine decarboxylase (ADC), spermidine synthase (SPDS), thermospermine synthase (ACL5) and diamine oxidase (DAO) were analyzed, as well as the expression of catalase (CAT), DNA repair genes (RAD51, KU80) and autophagy-related genes (ATG5, ATG8) throughout the induction of somatic embryo formation in Scots pine SE cultures.
TRIM5α degradation via autophagy is not required for retroviral restriction.
Campbell et al., Maywood, United States. In J Virol, Feb 2016
To test the requirement for macro-autophagy in restriction, we examined the ability of TRIM5α to restrict retroviral infection in cells depleted of autophagic mediators ATG5, Beclin1, and p62.
Exogenous hydrogen sulfide promotes cell proliferation and differentiation by modulating autophagy in human keratinocytes.
Li et al., Harbin, China. In Biochem Biophys Res Commun, Feb 2016
Blockage of autophagy by ATG5 siRNA inhibited NaHS-induced cell proliferation and differentiation.
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
Stallings et al., Saint Louis, United States. In Nature, Jan 2016
The involvement of autophagy has been defined based on studies in cultured cells where M. tuberculosis co-localizes with autophagy factors ATG5, ATG12, ATG16L1, p62, NDP52, BECN1 and LC3 (refs 2-6), stimulation of autophagy increases bacterial killing, and inhibition of autophagy increases bacterial survival.
Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population.
Yang et al., Chongqing, China. In Invest Ophthalmol Vis Sci, Jan 2016
Genotyping for genetic variants of 10 autophagy family genes (ATG5, ATG7, ATG10, ATG16L1, IRGM, LKKR2, ATG2A, DAP, ULK1, and TSC1) was performed using PCR-restriction fragment length polymorphism (PCR-RFLP) or TaqMan SNP assays.
Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis.
Simon et al., Bern, Switzerland. In J Mol Med (berl), Feb 2015
This review will address this topic with respect to autophagy-related protein 5 (ATG5), which in several lines of investigation has been ascribed special significance in the autophagic pathway.
Structural insights into E2-E3 interaction for LC3 lipidation.
Otomo et al., Los Angeles, United States. In Autophagy, 2014
This transfer is stimulated by the ATG12-ATG5-ATG16L1 E3 complex, but the mechanism is not fully understood.
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.
Kirkin et al., Germany. In Mol Cell, 2014
These proteins recognize autophagic cargo and, via binding to small ubiquitin-like modifiers (UBLs)--Atg8/LC3/GABARAPs and ATG5--mediate formation of selective autophagosomes.
The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.
Philpott et al., Toronto, Canada. In Immunity, 2013
Knockdown of ATG16L1 expression, but not that of ATG5 or ATG9a, specifically enhanced Nod-driven cytokine production.
Autophagosomes form at ER-mitochondria contact sites.
Yoshimori et al., Suita, Japan. In Nature, 2013
Imaging data reveal that the pre-autophagosome/autophagosome marker ATG14 (also known as ATG14L) relocalizes to the ER-mitochondria contact site after starvation, and the autophagosome-formation marker ATG5 also localizes at the site until formation is complete.
Molecular underpinning of extranodal NK/T-cell lymphoma.
Gaulard et al., Taiwan. In Best Pract Res Clin Haematol, 2013
Frequent deletions and promoter methylations in PRDM1, ATG5, AIM1, FOXO3, HACE1 mapping to 6q21-q25, suggest their roles as potential tumor suppressors.
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Ding et al., Kansas City, United States. In Toxicol Sci, 2012
Persistent activation of Nrf2 and increased hepatocyte proliferation protect against acetominophen-induced liver injury in Atg5 liver-specific knockout mice.
Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma.
Virgin et al., Saint Louis, United States. In Cell Host Microbe, 2012
Atg5-Atg12/Atg16L1 protein complex is required for IFNgamma-mediated host defense against murine norovirus infection.
Autophagy links inflammasomes to atherosclerotic progression.
Semenkovich et al., Saint Louis, United States. In Cell Metab, 2012
To determine whether autophagy directly influences atherogenesis, we characterized Beclin-1 heterozygous-null and mφ-specific ATG5-null (ATG5-mφKO) mice, commonly used models of autophagy haploinsufficiency and deficiency, respectively.
Macrophage autophagy plays a protective role in advanced atherosclerosis.
Tabas et al., New York City, United States. In Cell Metab, 2012
Inhibition of autophagy by silencing ATG5 or other autophagy mediators enhances apoptosis and NADPH oxidase-mediated oxidative stress while at the same time rendering the apoptotic cells less well recognized by efferocytes.
Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.
de Pablo et al., Madrid, Spain. In Autophagy, 2012
These results reveal new roles for autophagy-related molecules Atg5 and Ambra1 during early neuronal differentiation of stem/progenitor cells.
Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan.
Jendrach et al., Frankfurt am Main, Germany. In Autophagy, 2012
These data relate LC3B, ATG5 and ATG12 to mitochondrial quality control after oxidative damage, and to cellular longevity.
The end of autophagic cell death?
Kroemer et al., In Autophagy, 2012
Thus, knockdown of essential autophagy genes (such as ATG5 and ATG7) failed to prevent and rather accelerated chemotherapy-induced cell death, in spite of the fact that this manipulation efficiently inhibits autophagosome formation.
Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma.
Hershey et al., Cincinnati, United States. In Plos One, 2011
Genetic variants in ATG5, including a functional promotor variant, are associated with childhood asthma.
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