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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ATG4 autophagy related 4 homolog A

Atg4A, cysteine protease Atg4
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Atg8, STEP, Atg4B, Atg3, Atg7
Papers on Atg4A
Plasmodium falciparum erythrocytic stage parasites require the putative autophagy protein PfAtg7 for normal growth.
Drew et al., Columbus, United States. In Plos One, 2012
In yeast, Atg8 lipidation requires the E1-type ligase Atg7, an E2-type ligase Atg3, and a cysteine protease Atg4.
Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans.
Zhang et al., Beijing, China. In J Biol Chem, 2012
Here we investigated the role of the two Caenorhabditis elegans homologues of the cysteine protease Atg4 in the pathway responsible for degradation of protein aggregates.
Dual roles of Atg8-PE deconjugation by Atg4 in autophagy.
Xie et al., Tianjin, China. In Autophagy, 2012
Here we show that the deconjugation of Atg8-PE by the cysteine protease Atg4 plays dual roles in the formation of autophagosomes.
Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
Ratovitski et al., Baltimore, United States. In Cell Cycle, 2012
We found here that cisplatin exposure of SCC cells led to modulation of the members of the autophagic pathway, such as Atg1/Ulk1, Atg3, Atg4A, Atg5, Atg6/Becn1, Atg7, Atg9A and Atg10, by a direct p-ΔNp63α-dependent transcriptional regulation.
A high-throughput FRET-based assay for determination of Atg4 activity.
Yin et al., Indianapolis, United States. In Autophagy, 2012
In this study, a sensitive and specific method to measure the activity of two Atg4 homologs in mammalian cells, Atg4A and Atg4B, was developed using a fluorescence resonance energy transfer (FRET)-based approach.
Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis.
Ohsumi et al., Yokohama, Japan. In Autophagy, 2012
The cysteine protease Atg4 processes the C terminus of newly synthesized Atg8 and also delipidates Atg8 to release the protein from membranes.
Modulation of autophagy influences development and apoptosis in mouse embryos developing in vitro.
Kim et al., Ch'ŏngju, South Korea. In Mol Reprod Dev, 2011
Furthermore, both the expression of Lc3, Gabarap, Atg4A, and Atg4B, and the synthesis of LC3 were significantly reduced at the blastocyst stage.
Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.
Yin et al., Indianapolis, United States. In J Biol Chem, 2011
Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A for ATG8 substrates
Granulomas in Crohn's disease: are newly discovered genetic variants involved?
Eliakim et al., Israel. In J Crohns Colitis, 2010
no association between SNP rs807185 and the presence of granulomas in Crohn's disease
Under the ROS…thiol network is the principal suspect for autophagy commitment.
Ciriolo et al., Roma, Italy. In Autophagy, 2010
Nonetheless, the cysteine protease Atg4 remains the sole example of a protein whose redox regulation has been completely characterized and demonstrated to be necessary for the progression of autophagy.
A systematic bioinformatics approach for selection of target and screening of ligand for malignant tumours suppressing APG4A gene on Xq22.1.
Sivakumar et al., Bengaluru, India. In Int J Comput Biol Drug Des, 2009
statistical analysis of APG4A gene confirmed the characterisation of each protein-coding gene present in human genome Xq22.1
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.
Lane et al., Bristol, United Kingdom. In J Cell Sci, 2009
Autophagosome biogenesis is coordinated by the autophagy-related protein 4 (Atg4) family of C54 endopeptidases (Atg4A-Atg4D).
Ligand binding mode of GABAA receptor-associated protein.
Willbold et al., Jülich, Germany. In J Mol Biol, 2008
The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4.
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.
Elazar et al., Israel. In Embo J, 2007
The cysteine protease HsAtg4 is identified as a direct target for oxidation by hydrogen peroxide, and a cysteine residue located near the HsAtg4 catalytic site as critical for this regulation.
Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3.
Kominami et al., Tokyo, Japan. In Febs J, 2006
In vitro, the C-terminus of Atg8L was cleaved by human Atg4B, but not human Atg4A or Atg4C.
The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A.
Elazar et al., Israel. In J Biol Chem, 2003
HsApg4A cleaves the COOH terminus of GATE-16
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