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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ATG18 Atg18p

Atg18, Atg18p, WIPI49, WIPI-1
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Wip1, LC3, Atg1, CAN, Atg5
Papers on Atg18
Phosphatidylinositol 3,5-bisphosphate-rich membrane domains in endosomes and lysosomes.
Fujimoto et al., Nagoya, Japan. In Traffic, Dec 2015
GST-ATG18-4×FLAG was used to label PtdIns(3,5)P2 and its binding to phosphatidylinositol 3-phosphate [PtdIns(3)P] was blocked by an excess of the p40(phox) PX domain.
The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.
Camonis et al., Paris, France. In Curr Biol, Nov 2015
Upon autophagy induction, STK38-depleted cells display impaired LC3B-II conversion; reduced ATG14L, ATG12, and WIPI-1 puncta formation; and significantly decreased Vps34 activity, as judged by PI3P formation.
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Youle et al., Bethesda, United States. In Nature, Sep 2015
Once recruited to mitochondria, NDP52 and optineurin recruit the autophagy factors ULK1, DFCP1 and WIPI1 to focal spots proximal to mitochondria, revealing a function for these autophagy receptors upstream of LC3.
Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to Proinflammatory Cytokines-Implications for Disc Degeneration.
Hanley et al., Charlotte, United States. In Spine (phila Pa 1976), Jul 2015
In vitro, proinflammatory cytokines significantly upregulated autophagy-related genes (P ≤ 0.04): DRAM1 (6.24-fold); p62 (4.98-fold); PIM-2 oncogene, a positive regulator of autophagy (3-fold); WIPI49 (linked to starvation-induced autophagy) (upregulated 2.3-fold).
Characterization of PROPPIN-Phosphoinositide Binding and Role of Loop 6CD in PROPPIN-Membrane Binding.
Kühnel et al., Göttingen, Germany. In Biophys J, Jun 2015
ITC measurements showed that the yeast PROPPIN family members Atg18, Atg21, and Hsv2 bind PtdIns3P and PtdIns(3,5)P2 with high affinities in the nanomolar to low-micromolar range and have two phosphoinositide (PIP)-binding sites.
Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection.
Murata et al., Tokyo, Japan. In Plos Pathog, Mar 2015
Furthermore, we showed that the autophagy-related proteins Atg9 and WIPI1, but not DFCP1, were required for the biogenesis of the ER-derived membrane compartments.
Fluorescence-based imaging of autophagy progression by human WIPI protein detection.
Proikas-Cezanne et al., Tübingen, Germany. In Methods, Mar 2015
The specific autophagosomal localization of both WIPI1 and WIPI2 (refered to as WIPI puncta) has been employed to assess autophagy using fluorescence microscopy methods, such as confocal and live-cell video microscopy and was extended for automated high-throughput image acquisition and analyses procedures.
WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome.
Kohlbacher et al., Tübingen, Germany. In J Cell Sci, Feb 2015
Members of the human WD-repeat protein interacting with phosphoinositides (WIPI) family play an important role in recognizing and decoding the PtdIns3P signal at the nascent autophagosome, and hence function as autophagy-specific PtdIns3P-binding effectors, similar to their ancestral yeast Atg18 homolog.
TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy in Dictyostelium and human HeLa cells.
Escalante et al., Madrid, Spain. In Autophagy, 2014
Dictyostelium cells lacking TipC displayed a reduced number of autophagosomes visualized with the markers GFP-Atg18 and GFP-Atg8 and an impaired autophagic degradation as determined by a proteolytic cleavage assay.
ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae.
Cordero-Otero et al., Tarragona, Spain. In Plos One, 2014
Among the genes identified after reciprocal hemizygosity assays, RSM22, ATG18 and DBR1 had not been referenced in previous studies.
WIPI β-propellers in autophagy-related diseases and longevity.
Proikas-Cezanne et al., Tübingen, Germany. In Biochem Soc Trans, 2013
In the present article, we discuss the role of human WIPIs in autophagy, and the identification of evolutionarily conserved amino acids of WIPI-1 that confer PtdIns(3)P binding downstream of mTORC1 inhibition.
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood.
Matsumoto et al., Yokohama, Japan. In Nat Genet, 2013
WDR45 (also known as WIPI4) is one of the four mammalian homologs of yeast Atg18, which has an important role in autophagy.
Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2.
Ohsumi et al., Yokohama, Japan. In Febs Lett, 2012
effective targeting of Atg2 to the PAS can compensate for loss of Atg18 function in autophagy
Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes.
Robenek et al., Tübingen, Germany. In J Cell Mol Med, 2011
Freeze-fracture replica immunolabelling reveals WD-repeat protein interacting with phosphoinositides 1 and 2 (WIPI-1 and WIPI-2) as membrane components of autophagosomes and the plasma membrane (PM).
Autophagosome formation and molecular mechanism of autophagy.
Tanida, Japan. In Antioxid Redox Signal, 2011
Among the proteins and multimolecular complexes that contribute to autophagosome formation are the PI(3)-binding proteins, the PI3-phosphatases, the Rab proteins, the Atg1/ULK1 protein-kinase complex, the Atg9•Atg2-Atg18 complex, the Vps34-Atg6/beclin1 class III PI3-kinase complex, and the Atg12 and Atg8/LC3 conjugation systems.
WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition.
Ganesan et al., Irvine, United States. In J Biol Chem, 2011
Studies define a distinct role for WIPI1 and TORC1 signaling in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy.
Autophagy basics.
Tanida, Tokyo, Japan. In Microbiol Immunol, 2011
The "core" autophagy-related (Atg) complexes in mammals are ULK1 protein kinase, Atg9-WIPI-1 and Vps34-beclin1 class III PI3-kinase complexes, and the Atg12 and LC3 conjugation systems.
Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function.
Michell et al., Birmingham, United Kingdom. In Biochem J, 2009
Some putative PtdIns(3,5)P(2) effectors have been identified, including Atg18p-related PROPPIN [beta-propeller(s) that bind PPIn] proteins and the epsin-like proteins Ent3p and Ent5p, whereas others remain to be defined.
Dissecting the localization and function of Atg18, Atg21 and Ygr223c.
Thumm et al., Göttingen, Germany. In Autophagy, 2008
Deletion of ATG18, ATG21 and YGR223c, alone or simultaneously has no obvious function on the MVB-pathway and carboxypeptidase Y sorting.
The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function.
Ohsumi et al., Okazaki, Japan. In J Biol Chem, 2008
Atg18 forms a complex with Atg2 irrespective of PtdIns(3)P binding, associates tightly to autophagic membranes by interacting with PtdIns(3)P, and plays an essential role.
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