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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ATG10 Atg10p

Atg10, Apg10, ALBINO AND PALE GREEN 10, Apg10p
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Atg5, Atg12, Atg7, Ubiquitin, CAN
Papers on Atg10
Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population.
Yang et al., Chongqing, China. In Invest Ophthalmol Vis Sci, Jan 2016
Genotyping for genetic variants of 10 autophagy family genes (ATG5, ATG7, ATG10, ATG16L1, IRGM, LKKR2, ATG2A, DAP, ULK1, and TSC1) was performed using PCR-restriction fragment length polymorphism (PCR-RFLP) or TaqMan SNP assays.
Tomato HsfA1a plays a critical role in plant drought tolerance by activating ATG genes and inducing autophagy.
Zhou et al., Hangzhou, China. In Autophagy, Dec 2015
The expression of ATG10 and ATG18f, and the formation of autophagosomes were compromised in HsfA1a-silenced plants but were enhanced in HsfA1a-overexpressing plants.
Burkholderia pseudomallei survival in lung epithelial cells benefits from miRNA-mediated suppression of ATG10.
Mao et al., Chongqing, China. In Autophagy, 2014
In the present study, based on microarray screening, we found that ATG10 was downregulated following B. pseudomallei infection in A549 human lung epithelial cells.
Polymorphisms in autophagy genes are associated with paget disease of bone.
González Sarmiento et al., Salamanca, Spain. In Plos One, 2014
We have studied the distribution of genotypes of the ATG2B rs3759601, ATG16L1 rs2241880, ATG10 rs1864183 and ATG5 rs2245214 polymorphisms in a Spanish cohort of subjects with PDB and compared with healthy subjects.
Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.
Poletti et al., Milano, Italy. In Sci Rep, 2014
We also found a dramatic perturbation of the autophagic response, with upregulation of most autophagic markers (Beclin-1, ATG10, p62/SQSTM1, LC3) and of the HSPB8-mediated PQC response.
Autophagy suppression by appendicitis and appendectomy protects against colitis.
Grimm et al., Sydney, Australia. In Inflamm Bowel Dis, 2014
RESULTS: Out of 28 key autophagy-related genes investigated (VPS15, VPS34, FIP200, ATG03, ATG04A, ATG04B, ATG05, ATG07, ATG10, ATG12, ATG13b, ATG14, ATG16L1, BECN1, GABARAPL1, IRGM1, IRGM2, LAMP2, LC3A, LC3B, RAB7A, UVRAG, NOD2, XBP1, LRRK2, ULK1, ULK2, PTPN2), 7 have genetic associations with inflammatory bowel diseases (ATG16L1, IRGM1, NOD2, XBP1, LRRK2, ULK1, PTPN2).
Expression of autophagy and UPR genes in the developing brain during ethanol-sensitive and resistant periods.
Luo et al., Lexington, United States. In Metab Brain Dis, 2013
The expression of pro-apoptotic genes, such as caspase-3, was much higher on PD4 than PD12; in contrast, the expression of genes that regulate UPR and autophagy, such as atf6, atg4, atg9, atg10, beclin1, bnip3, cebpb, ctsb, ctsd, ctss, grp78, ire1α, lamp, lc3 perk, pik3c3, and sqstm1 was significantly higher on PD12 than PD4.
Potentially functional polymorphisms in ATG10 are associated with risk of breast cancer in a Chinese population.
Shen et al., Nanjing, China. In Gene, 2013
Thus, we systematically screened 14 potentially functional polymorphisms in six autophagy-related genes (ATG3, ATG5, ATG7, ATG10, and ATG12 and LC3) that are core components in autophagosome formation.
Amikacin-induced Fin Reduction is Mediated by Autophagy.
Wang et al., Taipei, Taiwan. In J Toxicol Pathol, 2013
In this study, we examined the expression of well-known autophagy markers mTOR (target of rapamycin), atg10 (autophagy-related gene), atg12 and LC3 (mammalian homolog of Atg8) in amikacin-treated zebrafish embryos.
Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells.
Dong et al., South Korea. In Plos One, 2012
The activation occurred through Sox2-mediated ATG10 gene expression and resulted in the inhibition of cell proliferation and anchorage-independent colony growth ex vivo and tumor growth in vivo.
Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis.
Kim et al., South Korea. In Plos One, 2011
Although the roles of a few ATG proteins in cancer have been characterized, the role of ATG10 is almost completely unknown.
Polymorphisms in autophagy genes and susceptibility to tuberculosis.
van Crevel et al., Nijmegen, Netherlands. In Plos One, 2011
No association was found between TB and polymorphisms in the genes ATG10, ATG16L2, ATG2B, ATG5, ATG9B, IRGM, LAMP1, LAMP3, P2RX7, WIPI1, MTOR and ATG4C.
IRGM in autophagy and viral infections.
Faure et al., Lyon, France. In Front Immunol, 2011
The physical association of IRGM with mitochondria and different autophagy-regulating proteins, ATG5, ATG10, SH3GLB1, and LC3, contribute to explain how IRGM could regulate autophagy.
The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana.
Vierstra et al., Madison, United States. In Genetics, 2008
These results indicate that ATG10 is essential for ATG12 conjugation and that the ATG12-ATG5 conjugate is necessary to form autophagic vesicles and for the timely progression of senescence and programmed cell death in plants.
ALBINO AND PALE GREEN 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana.
Shinozaki et al., Tsukuba, Japan. In Plant Cell Physiol, 2005
Arabidopsis albino and pale green 10 (apg10) mutant exhibits pale green cotyledons; APG10 encodes BBMII isomerase which is directly involved in His biosynthesis.[APG10]
The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.
Kominami et al., Tokyo, Japan. In J Biol Chem, 2003
The isolated mouse APG10 gene product interacts with mammalian Apg12p dependent on mammalian Apg7p (E1-like enzyme), and facilitates Apg12p conjugation.
Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.
Ohsumi et al., Kawaguchi, Japan. In Febs Lett, 2003
APG10 has a role in mediating the conjugation of APG12 with APG5
Molecular mechanism of autophagy in yeast, Saccharomyces cerevisiae.
Ohsumi, Okazaki, Japan. In Philos Trans R Soc Lond B Biol Sci, 1999
We also found that apg7 and apg10 mutants were unable to form an Apg12p-Apg5p conjugate.
A protein conjugation system essential for autophagy.
Ohsumi et al., Okazaki, Japan. In Nature, 1998
Of the apg mutants, we found that apg7 and apg10 were unable to form an Apg5/Apg12 conjugate.
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