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Mitogen-activated protein kinase kinase kinase 6

ASK2, MAP3K6, MAPKKK6, Apoptosis signal-regulating kinase 2
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ASK1, Skp1, ACID, Ubiquitin, SCF
Papers on ASK2
Mild and severe cereal yellow dwarf viruses differ in silencing suppressor efficiency of the P0 protein.
Ziegler-Graff et al., Strasbourg, France. In Virus Res, Nov 2015
Finally both P0(CY-RPV) and P0(CY-RPS) interacted in yeast cells with ASK2, a component of an E3-ubiquitin ligase, with distinct affinities.
Hereditary diffuse gastric cancer: What the clinician should know.
Ngeow et al., Singapore, Singapore. In World J Gastrointest Oncol, Oct 2015
Recent findings of other gene defects in CTNNA1 and MAP3K6, as well as further characterization of CDH1 mutations and their pathogenicity will change the way HDGC patients are counselled for screening, surveillance and treatment.
Genome-wide analysis of phylogeny, expression profile and sub-cellular localization of SKP1-Like genes in wild tomato.
Hua et al., Beijing, China. In Plant Sci, Sep 2015
Based on phylogenetic analysis, expression profiles and protein interaction property, we proposed that tomato SSK1 and SSK2 might have similar function to ASK1 and ASK2 in Arabidopsis.
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Gotoh et al., Tokyo, Japan. In Sci Signal, Sep 2015
In contrast, we found that the MAPKKK ASK2, a modulator of ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing IFNB expression.
Recognition of and recent issues in hereditary diffuse gastric cancer.
Kanai et al., Tokyo, Japan. In J Gastroenterol, Aug 2015
Because of these advances, searches for candidate genes (e.g., CTNNA1, MAP3K6) and our understanding of HDGC pathogenesis have improved in recent years; moreover, there have been substantial changes in the field since the current HDGC consensus guidelines were released.
Distinct roles of FKF1, Gigantea, and Zeitlupe proteins in the regulation of Constans stability in Arabidopsis photoperiodic flowering.
Imaizumi et al., Suwŏn, South Korea. In Proc Natl Acad Sci U S A, 2015
First, our immunoprecipitation-mass spectrometry analysis of FKF1 revealed that FKF1 forms an S-phase kinase-associated protein 1 (Skp1)/Cullin(CUL)/F-box complex through interactions with Arabidopsis Skp1-like 1 (ASK1), ASK2, and CUL1 proteins and mainly interacts with GI protein in vivo.
A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications.
Sheng et al., Roanoke, United States. In Autophagy, 2014
The RNAi screen revealed WNK2 and MAP3K6 as autophagy-modulating genes, both of which inhibited the MTOR pathway.
Germline mutations in MAP3K6 are associated with familial gastric cancer.
Bedard et al., Halifax, Canada. In Plos Genet, 2014
Here we examined a large family from Maritime Canada with FGC without CDH1 mutations, and identified a germline coding variant (p.P946L) in mitogen-activated protein kinase kinase kinase 6 (MAP3K6).
Targeting apoptosis signalling kinase-1 (ASK-1) does not prevent the development of neuropathy in streptozotocin-induced diabetic mice.
Gardiner et al., Manchester, United Kingdom. In Plos One, 2013
However, levels of ASK2 mRNA increase in the spinal cord at 4 weeks of diabetes, which could represent a future target for this field.
Salt-responsive ERF1 regulates reactive oxygen species-dependent signaling during the initial response to salt stress in rice.
Mueller-Roeber et al., Potsdam, Germany. In Plant Cell, 2013
Furthermore, we show that SERF1-dependent genes are H2O2 responsive and demonstrate that SERF1 binds to the promoters of MAPK kinase kinase6 (MAP3K6), MAPK5, dehydration-responsive element bindinG2A (DREB2A), and zinc finger protein179 (ZFP179) in vitro and in vivo.
Structural, expression and interaction analysis of rice SKP1-like genes.
Bouzidi et al., Clermont-Ferrand, France. In Dna Res, 2013
We suggest that rice OSK1 and OSK20 are likely to have functions similar to the Arabidopsis ASK1 and ASK2 genes.
Several components of SKP1/Cullin/F-box E3 ubiquitin ligase complex and associated factors play a role in Agrobacterium-mediated plant transformation.
Mysore et al., Ardmore, United States. In New Phytol, 2012
ASK1 and ASK2, are required for Agrobacterium-mediated plant transformation.
SKP1 is involved in abscisic acid signalling to regulate seed germination, stomatal opening and root growth in Arabidopsis thaliana.
Xu et al., Beijing, China. In Plant Cell Environ, 2012
ASK1 or ASK2 overexpression could rescue or partially rescue the Abscisic acid (ABA)insensitivity of abi5-1 mutants, respectively.
Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.
Tan et al., Singapore, Singapore. In Cancer Res, 2011
When applied to primary GCs, we identified somatic mutations in 8 kinases, 4 of which were recurrently altered in both primary tumors and cell lines (MAP3K6, STK31, FER, and CDKL5).
Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.
Nangaku et al., Tokyo, Japan. In Am J Pathol, 2009
regulation of VEGF by MAP3K6 may play a crucial role in both angiogenesis and tumorigenesis.
ASK family proteins in stress response and disease.
Ichijo et al., Tokyo, Japan. In Mol Biotechnol, 2007
Here, we highlight the roles of members of the ASK family, which consists of ASK1 and newly characterized ASK2, in ROS signaling with their possible involvement in human diseases.
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
Ichijo et al., Tokyo, Japan. In J Biol Chem, 2007
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
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