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Amiloride-sensitive cation channel 4, pituitary

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, ASIC1a, ASIC3, ASIC2, ENaC
Papers on ASIC4
Genetic exploration of the role of acid-sensing ion channels.
Chen et al., Taipei, Taiwan. In Neuropharmacology, Jul 2015
Here we review studies involving genetically engineered mouse models used to investigate the physiological function of individual ASIC subtypes: ASIC1 (and ASIC1a), ASIC2, ASIC3 and ASIC4.
Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety.
Chen et al., Taipei, Taiwan. In Eur J Neurosci, Jun 2015
Although ASIC4 is a member of the acid-sensing ion channel (ASIC) family, we have limited knowledge of its expression and physiological function in vivo.
Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish.
García-Suárez et al., Oviedo, Spain. In Cell Tissue Res, May 2015
We study the expression and distribution of ASIC2 and ASIC4 in the retina of adult zebrafish and its regulation by light using PCR, in situ hybridization, western blot and immunohistochemistry.
The role of acid-sensing ion channels in epithelial Na+ uptake in adult zebrafish (Danio rerio).
Goss et al., Edmonton, Canada. In J Exp Biol, May 2015
Using molecular and histological techniques we found that asic genes and the ASIC4.2 protein are expressed in the gill of adult zebrafish.
Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.
Gründer et al., Aachen, Germany. In Sci Rep, 2014
Six different ASICs have been identified (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4) that are activated by a drop in extracellular pH, either as homo- or heteromers.
Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss.
Goss et al., Edmonton, Canada. In Am J Physiol Cell Physiol, 2014
Furthermore, we cloned the trout ASIC1 and ASIC4 homologs and demonstrated that they are expressed differentially in the tissues of the rainbow trout, including gills and isolated mitochondrion-rich cells.
In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3.
Smith et al., Cambridge, United Kingdom. In Biochem Biophys Res Commun, 2014
Amongst the six ASIC isoforms, ASIC1a, 1b, 2a and 3 form proton-gated homomers, which differ in their activation and inactivation kinetics, expression profiles and pharmacological modulation; protons do not gate ASIC2b and ASIC4.
Acid-sensing ion channels in healthy and degenerated human intervertebral disc.
Vega et al., In Connect Tissue Res, 2014
In this study, the expression of ASICs (ASIC1, ASIC2, ASIC3 and ASIC4) mRNAs and proteins in human healthy and degenerated IVD was evaluated by quantitative reverse transcription-quantitative polymerase chain reaction and Western blot.
Expression and activity of acid-sensing ion channels in the mouse anterior pituitary.
Welsh et al., Iowa City, United States. In Plos One, 2013
We sought to investigate which ASIC subunits were present in the pituitary and found mRNA expression for all ASIC isoforms, including ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3 and ASIC4.
Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish.
Vega et al., Oviedo, Spain. In Neurosci Lett, 2013
In the present study the presence of ASICs (ASIC1, ASIC2, ASIC3 and ASIC4) was investigated in the taste buds of adult zebrafish (zASICs) using Western blot and immunohistochemistry. zASIC1 and zASIC3 were regularly absent from taste buds, whereas faint zASIC2 and robust zASIC4 immunoreactivities were detected in sensory cells.
Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins.
Vega et al., Oviedo, Spain. In Microsc Res Tech, 2011
Positive and specific immunoreactivity in the odontoblast soma and/or processes was detected for all proteins studied except α-ENa(+) C. The intensity of immunostaining was high for β-ENa(+) C and ASIC2, whereas it was low for ASIC1, ASIC3, γ-ENa(+) C, and TRPV4, being absent for α-ENa(+) C and ASIC4.
Febrile seizures: characterization of double-stranded RNA-induced gene expression.
Hamasaki et al., Saga, Japan. In Pediatr Neurol, 2009
Compared with the control group, expression of the genes ACCN4 (sodium channel), KCNC3 (potassium channel), GABRE (gamma-aminobutyric acid receptor epsilon subunit), RIPK2 (receptor interacting protein kinase-2), TLR4 (toll-like receptor-4), IL26 (interleukin-26), and TNF (tumor necrosis factor), and CASP1 (caspase-1) was increased in the febrile seizure group (P < 0.01).
Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse.
Vardi et al., Philadelphia, United States. In J Comp Neurol, 2008
The following transcripts were not found in our library: AGS3 (GPSM1), RGS10, RGS19 (GAIP), calbindin, GC1alpha2, GC1beta2, PDE5, PDE2A, amiloride-sensitive sodium channel ACCN4, and CatSper1.
Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.
Wood et al., London, United Kingdom. In Eur J Neurosci, 2008
Data show that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells, where it associates with ASIC1a and downregulates exogenous ASIC1a expression.
Peptides inhibitors of acid-sensing ion channels.
Lazdunski et al., Antibes, France. In Toxicon, 2007
ASICs comprise four proteins forming functional channel subunits (ASIC1a, ASIC1b, ASIC2a, and ASIC3) and two proteins (ASIC2b and ASIC4) without yet known activators.
Acid sensing ionic channels: modulation by redox reagents.
Krishtal et al., Kiev, Ukraine. In Biochim Biophys Acta, 2005
Acid-sensing ion channel currents are susceptible to regulation by redox agents. (Acid-sensing ion channels)
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