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Amiloride-sensitive cation channel 1, neuronal

ASIC2, ASIC2a, BNC1, Acid-sensing ion channel 2, ACCN1
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, ASIC1a, ASIC3, CAN, HAD
Papers on ASIC2
NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats.
Ahring et al., Ballerup, Denmark. In Cns Neurosci Ther, Feb 2016
However, NS383 was completely inactive at homomeric ASIC2a.
Diminazene aceturate-An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
de Freitas et al., Teresina, Brazil. In Pharmacol Res, Dec 2015
It was thus possible to highlight several researches that have investigated alternatives in order to improve success in the treatment of animal trypanosomiasis, by using new drugs in associations with diminazene aceturate, as well as looking for new pharmacological applications for this compound, such as leishmanicidal, amebicidal, anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent, and mainly as an activator of angiotensin-converting enzyme 2. Another pharmacological property still little studied is the inhibition of acid-sensitive ion channels (ASIC1a, ASIC1b, ASIC2a and ASIC3), which are related to the development of various diseases.
ASIC subunit ratio and differential surface trafficking in the brain.
Zha et al., Mobile, United States. In Mol Brain, Dec 2015
Further, we investigated differential surface trafficking of ASIC1a, ASIC2a, and ASIC2b.
Unique roles played by Acid-sensing ion channel 2.
Lin et al., China. In Channels (austin), Dec 2015
They belong to the degenerin/epithelial Na(+) channel family and function once extracellular pH decreases to a certain level, and this characteristic make them spotlights in the regulation or response of pH change.
ASICs and cardiovascular homeostasis.
Benson et al., Iowa City, United States. In Neuropharmacology, Jul 2015
We identified a role for ASIC2 in the mechano-sensitivity of aortic baroreceptors and of ASIC3 in the pH sensitivity of carotid bodies.
Acid-sensing ion channels in gastrointestinal function.
Holzer, Graz, Austria. In Neuropharmacology, Jul 2015
In the gut, ASICs (ASIC1, ASIC2, ASIC3) are primarily expressed by the peripheral axons of vagal and spinal afferent neurons and are responsible for distinct proton-gated currents in these neurons.
Genetic exploration of the role of acid-sensing ion channels.
Chen et al., Taipei, Taiwan. In Neuropharmacology, Jul 2015
Here we review studies involving genetically engineered mouse models used to investigate the physiological function of individual ASIC subtypes: ASIC1 (and ASIC1a), ASIC2, ASIC3 and ASIC4.
Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults.
Ye et al., China. In Int J Clin Exp Pathol, 2014
In wild-type cultured cortical neurons, not only the amplitude of ASICs current and the calcium transients induced by acidosis were both increased after OGD-Rep, but also the total protein levels of ASIC1 and ASIC2a were up-regulated progressively after ischemia insults, indicating that ASICs play a vital role in neuronal ischemia.
Acid-Sensing Ion Channels Expression, Identity and Role in the Excitability of the Cochlear Afferent Neurons.
Soto et al., Puebla de Zaragoza, Mexico. In Front Cell Neurosci, 2014
Gadolinium and acetylsalicylic acid reduced these currents, and FMRFamide, zinc (at high concentrations) and N,N,N',N'-tetrakis-(2-piridilmetil)-ethylenediamine increased them, indicating that functional ASICs are composed of the subunits ASIC1, ASIC2, and ASIC3.
Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.
Gründer et al., Aachen, Germany. In Sci Rep, 2014
Six different ASICs have been identified (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4) that are activated by a drop in extracellular pH, either as homo- or heteromers.
Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc.
Vega et al., South Korea. In Int J Clin Exp Pathol, 2014
The expression of ASIC2 and TrkB in human normal and degenerated IVD was assessed using quantitative-PCR, Western blot, and immunohistochemistry.
[Acid-Sensing Ion Channels (ASICs) in pain].
Lingueglia, Antibes, France. In Biol Aujourdhui, 2013
The ASIC1 and ASIC3 isoforms are particularly important in sensory neurons, whereas ASIC1a, alone or in association with ASIC2, is essential in the central nervous system.
Black mamba venom peptides target acid-sensing ion channels to abolish pain.
Lingueglia et al., France. In Nature, 2012
Pharmacological inhibition by mambalgins combined with the use of knockdown and knockout animals indicates that blockade of heteromeric channels made of ASIC1a and ASIC2a subunits in central neurons and of ASIC1b-containing channels in nociceptors is involved in the analgesic effect of mambalgins.
Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schönlein purpura.
Zhou et al., Hefei, China. In J Pediatr Gastroenterol Nutr, 2012
The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.
Mors et al., Århus, Denmark. In Eur J Hum Genet, 2012
ACCN1 might be one of numerous susceptibility genes for panic disorder.
Fine mapping of dental fluorosis quantitative trait loci in mice.
Zou et al., Chapel Hill, United States. In Eur J Oral Sci, 2011
loss of ACCN1 function does not modify dental fluorosis severity in mice
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain.
Julius et al., San Francisco, United States. In Nature, 2011
MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH < 6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels.
Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder.
Patrinos et al., Cagliari, Italy. In Pharmacogenomics, 2011
these results indicate that ACCN1 gene is a potential candidate for response to lithium treatment that would serve as a genetic marker of lithium efficacy for bipolar disorder patients.
Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus.
Ueta et al., Kitakyūshū, Japan. In J Physiol, 2010
Suggest that interaction between ASICs and lactate in the supraoptic nucleus plays an important role in the regulatory mechanism of body fluid homeostasis.
The mammalian sodium channel BNC1 is required for normal touch sensation.
Welsh et al., Iowa City, United States. In Nature, 2000
However, the similarity of the brain sodium channel 1 (BNC1) to nematode proteins involved in mechanotransduction indicated that it might be a part of such a mechanosensor.
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