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Amiloride-sensitive cation channel 2, neuronal

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, ASIC2, ASIC3, CAN, HAD
Papers on ASIC1a
Novel developments in genetic and epigenetic mechanisms of anxiety.
Domschke et al., Würzburg, Germany. In Curr Opin Psychiatry, Jan 2016
Variants in RGS2 and ASIC1 genes were linked to panic disorder, with the latter also being implicated in SAD treatment response.
PICK1/Calcineurin Suppress ASIC1-mediated Ca2+ Entry in Rat Pulmonary Arterial Smooth Muscle Cells.
Jernigan et al., Mexico. In Am J Physiol Cell Physiol, Jan 2016
UNASSIGNED: Acid sensing ion channel 1 (ASIC1) contributes to Ca(2+) influx and contraction in pulmonary arterial smooth muscle cells (PASMC).
Diminazene aceturate-An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
de Freitas et al., Teresina, Brazil. In Pharmacol Res, Dec 2015
It was thus possible to highlight several researches that have investigated alternatives in order to improve success in the treatment of animal trypanosomiasis, by using new drugs in associations with diminazene aceturate, as well as looking for new pharmacological applications for this compound, such as leishmanicidal, amebicidal, anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent, and mainly as an activator of angiotensin-converting enzyme 2. Another pharmacological property still little studied is the inhibition of acid-sensitive ion channels (ASIC1a, ASIC1b, ASIC2a and ASIC3), which are related to the development of various diseases.
ASIC subunit ratio and differential surface trafficking in the brain.
Zha et al., Mobile, United States. In Mol Brain, Dec 2015
However, little is known about the relative abundance of different ASIC subunits in the brain.
Regulating Factors in Acid-Sensing Ion Channel 1a Function.
Huang et al., Hefei, China. In Neurochem Res, Dec 2015
UNASSIGNED: In recent years, research of acid sensing ion channels (ASICs) has increased tremendously, especially studies focusing on ASIC1a, which plays a critical role in many important physiologic and pathological functions.
Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems.
Lingueglia et al., France. In Neuropharmacology, Jul 2015
Channels containing ASIC3 or ASIC1 subunits, appear to be important in peripheral nociceptors, where they are subject to intense regulation, while ASIC1a-containing channels also have a prominent role in central neurons, including spinal cord neurons that modulate and transmit the pain signal to the brain.
Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons.
Wu et al., Hefei, China. In J Neuroinflammation, 2014
Further mechanistic studies revealed that acidosis-induced ASIC1a activation results in the increase of BK channel currents, with the subsequent K(+) efflux and a low concentration of intracellular K(+), which activated NLRP1 inflammasome.
A Review of Recent Patents on the ASICs as a Key Drug Target.
Quintans-Junior et al., São Cristóvão, Brazil. In Recent Pat Biotechnol, 2014
Drugs acting as antagonist in ASIC1 or ASIC3 channels seem to be the most promising targets.
Acid-Sensing Ion Channels Expression, Identity and Role in the Excitability of the Cochlear Afferent Neurons.
Soto et al., Puebla de Zaragoza, Mexico. In Front Cell Neurosci, 2014
There are four genes (ASIC1-4) that encode six subunits, and they are involved in diverse neuronal functions, such as mechanosensation, learning and memory, nociception, and modulation of retinal function.
Effect of activation of the Ca(2+)-permeable acid-sensing ion channel 1a on focal cerebral ischemia in diabetic rats.
Xing et al., Changchun, China. In Int J Clin Exp Pathol, 2014
We investigated the role of acid-sensing ion channel Ia (ASIC1a) expression and changes in intracellular Ca(2+) concentration ([Ca(2+)]) in focal cerebral ischemia after middle cerebral artery occlusion (MCAO) in a rat model of diabetes mellitus (DM).
X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel.
Gouaux et al., Portland, United States. In Cell, 2014
The ASIC1a-MitTx complex illuminates the mechanism of MitTx action, defines the structure of the selectivity filter of voltage-independent, sodium-selective ion channels, and captures the open state of an ASIC.
Black mamba venom peptides target acid-sensing ion channels to abolish pain.
Lingueglia et al., France. In Nature, 2012
Pharmacological inhibition by mambalgins combined with the use of knockdown and knockout animals indicates that blockade of heteromeric channels made of ASIC1a and ASIC2a subunits in central neurons and of ASIC1b-containing channels in nociceptors is involved in the analgesic effect of mambalgins.
Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes.
Gouaux et al., Portland, United States. In Nature, 2012
Here we show that psalmotoxin activates non-selective and Na(+)-selective currents in chicken ASIC1a at pH 7.25 and 5.5, respectively.
PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity.
Xu et al., Shanghai, China. In J Neurosci, 2012
Thus, our results reveal a novel mechanism underlying central sensitization and pain hypersensitivity, and reinforce the critical role of ASIC1a channels in these processes.
Contribution of residues in second transmembrane domain of ASIC1a protein to ion selectivity.
Della Vecchia et al., Pittsburgh, United States. In J Biol Chem, 2012
Our results indicate that ion selectivity is accomplished by the contribution of multiple sites in the pore of ASIC1a.
Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schönlein purpura.
Zhou et al., Hefei, China. In J Pediatr Gastroenterol Nutr, 2012
The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.
N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling.
Zha et al., Mobile, United States. In J Neurosci, 2012
ASIC1a N366Q, which showed increased glycosylation and dendritic targeting, potentiated acidosis-induced spine loss.
Chronic hypoxia upregulates pulmonary arterial ASIC1: a novel mechanism of enhanced store-operated Ca2+ entry and receptor-dependent vasoconstriction.
Resta et al., Albuquerque, United States. In Am J Physiol Cell Physiol, 2012
This study supports a novel role of ASIC1 in elevated receptor-stimulated vasoconstriction following chronic hypoxia which is likely mediated through increased ASIC1 expression and store-operated Ca(2 ) entry.
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain.
Julius et al., San Francisco, United States. In Nature, 2011
findings reveal a mechanism whereby snake venoms produce pain, and highlight an unexpected contribution of ASIC1 channels to nociception
The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.
Wemmie et al., Iowa City, United States. In Cell, 2009
Because the amygdala expresses acid-sensing ion channel-1a (ASIC1a), and ASIC1a is required for normal fear responses, we hypothesized that the amygdala might detect a reduced pH.
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