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Ankyrin repeat and SOCS box containing 2

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: Ubiquitin, ACID, CIs, HAD, Cullin
Papers on Asb-2
Genome-wide RNA-Seq analysis of breast muscles of two broiler chicken groups differing in shear force.
Gurgul et al., Poland. In Anim Genet, Feb 2016
The up-regulated gene group included the ASB2 gene, which is probably involved in the meat conversion process, as its product results in the degradation of filamins, proteins which form muscle fibres.
Assessment of current adhesives in class I cavity: Nondestructive imaging using optical coherence tomography and microtensile bond strength.
Giannini et al., Piracicaba, Brazil. In Dent Mater, Sep 2015
METHODS: Round tapered dentin cavities (3-mm diameter, 1.5-mm height) prepared in extracted human molars were restored using composite resin (Clearfil Majesty Posterior) with two-step etch-and-rinse adhesive system (Adper Single Bond 2: ASB2), two-step self-etch adhesive (Clearfil SE Bond: CSEB), all-in-one adhesives (G-Bond Plus: GBP; Tri-S Bond Plus: TSBP), or no adhesive (Control), or bonded using low-shrinkage composite with its proper adhesive (Filtek Silorane, Silorane Adhesive System: FSS).
Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells.
Lutz et al., Toulouse, France. In Sci Rep, 2014
Finally, we develop quantitative global proteomic approaches to identify ASB2α substrates in DCs using ASB2 conditional knockout mice.
Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins.
Sasaki et al., Tokushima, Japan. In Genes Cells, 2013
Expression of ASB2 induced degradation of all three filamin isoforms and inhibited the JRABΔCC-induced cell spreading.
ASB2α regulates migration of immature dendritic cells.
Lutz et al., Toulouse, France. In Blood, 2013
Using ASB2 conditional knockout mice, we show that ASB2α is a critical regulator of cell spreading and podosome rosette formation in immature DCs.
Genetic polymorphism of Hucul horse population based on 17 microsatellite loci.
Piestrzyńska-Kajtoch et al., Kraków, Poland. In Acta Biochim Pol, 2012
The set of seventeen microsatellites loci was tested (AHT4, AHT5, ASB2, HMS2, HMS3, HMS6, HMS7, HTG10, HTG4, HTG6, HTG7, VHL20, ASB17, ASB23, CA425, HMS1, LEX3) for 216 individuals.
The ASB2β Ubiquitin-interacting motif is involved in its monoubiquitination.
Kohroki et al., Chiba, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that ASB2beta but not ASB2alpha might be monoubiquitinated and that the ASB2beta UIM motif, but not its E3 Ub ligase activity, plays a pivotal role in this monoubiquitination.
Interfacial integrity of bonded restorations with self-etching adhesives: Water storage and thermo-mechanical cycling.
Gomes et al., Ponta Grossa, Brazil. In Eur J Dent, 2012
METHODS: Sixty Class V composite restorations were made in 30 premolars and bonded with Adper Single Bond 2 (ASB2), AdheSE (ASE), and Adper Prompt L-Pop (APL-P) (n=20).
ECSASB2 mediates MLL degradation during hematopoietic differentiation.
Hess et al., Ann Arbor, United States. In Blood, 2012
A model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL degradation and HOX gene down-regulation.
A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation.
Sun et al., Oklahoma City, United States. In J Biol Chem, 2012
NOTCH signaling is known to transcriptionally activate the genes encoding ASB2 (ankyrin-repeat SOCS box containing protein 2) and SKP2 (S-phase kinase-associated protein 2).
Effect of bleaching on shear bond strength to dentin of etch-and-rinse and self-etching primer adhesives.
Leite-Cavalcanti et al., Recife, Brazil. In Acta Odontol Latinoam, 2011
One hundred and twenty bovine incisors were divided into 12 groups (n = 10), according to adhesive system: Adper Single Bond 2 (ASB2), Prime & Bond 2.1 (PB), Adhese (AD) and Clearfil SE Bond (SE).
Population studies of 17 equine STR for forensic and phylogenetic analysis.
Lenstra et al., Wageningen, Netherlands. In Anim Genet, 2011
Population studies were performed for 17 polymorphic STR loci (AHT4, AHT5, ASB2, ASB17, ASB23, CA425, HMS1, HMS2, HMS3, HMS6, HMS7, HTG4, HTG6, HTG7, HTG10, LEX3 and VHL20) including 8641 horses representing 35 populations.
Comprehensive trapping of polyubiquitinated proteins using the UIM peptide of ASB2a.
Masuho et al., Chiba, Japan. In Biochem Biophys Res Commun, 2011
An alternative splicing variant of E3 ubiquitin ligase ASB2, termed ASB2a, has a distinct N-terminal sequence containing a ubiquitin-interacting motif (UIM) consensus sequence.
Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells.
Lutz et al., Toulouse, France. In J Biol Chem, 2011
ASB2alpha is a novel regulator of integrin-dependent adhesion of hematopoietic cells
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
Sun et al., Oklahoma City, United States. In Cell Res, 2011
By shifting monomeric E3 ligase complexes to dimeric forms through activation of Asb2 transcription, Notch could effectively control the turnover of a variety of substrates and it exerts diverse effects on cell proliferation and differentiation.
Deep sequencing the transcriptome reveals seasonal adaptive mechanisms in a hibernating mammal.
Andrews et al., Duluth, United States. In Plos One, 2010
Abundant RNAs in skeletal muscle coding ubiquitin pathway proteins ASB2, UBC and DDB1 peak in October, suggesting an increase in muscle proteolysis.
The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.
Lutz et al., Toulouse, France. In Cell Death Differ, 2009
ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B for proteasomal degradation.
Genetic diversity and admixture analysis of Sanfratellano and three other Italian horse breeds assessed by microsatellite markers.
Marletta et al., Catania, Italy. In Animal, 2008
A total of 111 alleles from 11 microsatellite loci were detected, from four at HTG7 to 15 at ASB2 locus.
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