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Aryl hydrocarbon receptor

aryl hydrocarbon receptor, AHR
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, CYP1A1, ACID
Papers using aryl hydrocarbon receptor antibodies
Adult hypertension and kidney disease: the role of fetal programming.
Ramos Kenneth S. et al., In Environmental Health Perspectives, 2005
... suppressor (WT1) antibody (180 amino acids in length; Santa Cruz Biotechnology, Santa Cruz, CA) or AHR rabbit polyclonal antibodies (Biomol International, Plymouth Meeting, PA) ...
Papers on aryl hydrocarbon receptor
Aryl hydrocarbon receptor-driven signals inhibit collagen synthesis in the gut.
Monteleone et al., Roma, Italy. In Eur J Immunol, Feb 2016
Here we investigated the role of aryl hydrocarbon receptor (AhR) in intestinal fibrosis.
Chrysin alleviates allergic inflammation and airway remodeling in a murine model of chronic asthma.
Feng et al., Nanjing, China. In Int Immunopharmacol, Feb 2016
The present study aimed to investigate whether chrysin could relieve allergic airway inflammation and remodeling in a murine model of chronic asthma and the mechanism involved.
CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.
Yang et al., Chongqing, China. In Dig Dis Sci, Feb 2016
Recent advances have also highlighted the importance of diet-derived substances and commensal metabolites, such as the aryl hydrocarbon receptor ligands and vitamin D, in controlling the survival and gene expression of CD8αα(+)TCRαβ(+) IELs.
Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma.
Kim et al., Seoul, South Korea. In Pulm Pharmacol Ther, Feb 2016
Inflammatory cells, T helper 2 cytokines in bronchoalveolar lavage fluid (BAL) fluid, and airway hyperresponsiveness (AHR) were measured.
Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft.
Bleul et al., Minneapolis, United States. In Cell Stem Cell, Feb 2016
We have evaluated the feasibility and safety of StemRegenin-1 (SR-1), an aryl hydrocarbon receptor antagonist that expands CD34+ cells, by placing one of the two units in expansion culture.
In vitro dioxin-like potencies of HO- and MeO-PBDEs and inter-species sensitivity variation in birds.
Yu et al., Nanjing, China. In Ecotoxicol Environ Saf, Feb 2016
In the present study, an avian AHR1 luciferase reporter gene (LRG) assay with luciferase probes from chicken, pheasant and quail was used to test activations of avian aryl hydrocarbon receptor (AHR)-mediated pathways by 19 HO- or MeO-PBDEs in different avian species.
AHR Function in Lymphocytes: Emerging Concepts.
Zhou, Chicago, United States. In Trends Immunol, Jan 2016
The aryl hydrocarbon receptor (AHR) is an important regulator of the development and function of both innate and adaptive immune cells through roles associated with AHR's ability to respond to cellular and dietary ligands.
Cockroach Allergen Exposure and Risk of Asthma.
Gao et al., Baltimore, United States. In Allergy, Jan 2016
Environmental pollutants, which often co-exist with the allergen, could synergistically elicit allergic inflammation, and aryl hydrocarbon receptor (AhR) activation and signaling may serve as a link between these two elements.
Interleukin (IL)-25: Pleiotropic roles in asthma.
Sun et al., Beijing, China. In Respirology, Jan 2016
Growing evidence from experimental and clinical studies indicates that the expression of IL-25 and its cognate receptor, IL-17RB/RA, is markedly upregulated in asthmatic conditions.
Runx3 specifies lineage commitment of innate lymphoid cells.
Yokoyama et al., Saint Louis, United States. In Nat Immunol, Nov 2015
Runx3 was required for expression of the transcription factor RORγt and its downstream target, the transcription factor AHR, in ILC3 cells.
Omeprazole does not Potentiate Acute Oxygen Toxicity in Fetal Human Pulmonary Microvascular Endothelial Cells Exposed to Hyperoxia.
Shivanna et al., Houston, United States. In Pharm Anal Acta, Oct 2015
Earlier we observed that OM-mediated aryl hydrocarbon receptor (AhR) activation attenuates acute hyperoxic lung injury in adult mice and oxygen toxicity in adult human lung cells.
Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells.
Avram et al., Albany, United States. In Immunity, Sep 2015
Additionally, independent of Gfi1, Bcl11b directly repressed expression of the gene encoding the ILC3 transcription factor Ahr, further contributing to silencing of ILC3 genes in ILC2s.
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Flavell et al., New Haven, United States. In Nature, Aug 2015
Comparisons of the transcriptional profiles of pre- and post-conversion Th17 cells also revealed a role for canonical TGF-β signalling and consequently for the aryl hydrocarbon receptor (AhR) in conversion.
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
Quintana et al., Boston, United States. In Nat Med, Jun 2015
We report that a metabolic program controlled by the transcription factors hypoxia inducible factor-1α (HIF1-α) and aryl hydrocarbon receptor (AHR) supports the differentiation of type 1 regulatory T cell (Tr1) cells.
Diverse Mechanisms of Sp1-Dependent Transcriptional Regulation Potentially Involved in the Adaptive Response of Cancer Cells to Oxygen-Deficient Conditions.
Miyagi et al., Yokohama, Japan. In Cancers (basel), 2014
HIFs, complexed with the aryl hydrocarbon receptor nuclear translocator, bind to and activate target genes as enhancers of transcription.
p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines.
Chan et al., Việt Trì, Vietnam. In Biochem Pharmacol, 2012
p23 co-chaperone protects the aryl hydrocarbon receptor from degradation
Genetic and epigenetic regulation of AHR gene expression in MCF-7 breast cancer cells: role of the proximal promoter GC-rich region.
Spink et al., Albany, United States. In Biochem Pharmacol, 2012
studies revealed multiple levels at which AhR expression may be controlled, and offer additional insights into mechanisms regulating AhR expression that can ultimately impact carcinogenesis
Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes.
Flaws et al., Urbana, United States. In Am J Obstet Gynecol, 2012
genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels
Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption.
El-Sohemy et al., Toronto, Canada. In Am J Clin Nutr, 2012
genetic association studies in Costa Rican population: Previous associations observed between SNPs in AHR (rs6968865; rs4410790) and caffeine/coffee consumption in European populations are also observed in ethnically distinct Costa Rican population.
The aryl hydrocarbon receptor pathway: a key component of the microRNA-mediated AML signalisome.
Fry et al., Chapel Hill, United States. In Int J Environ Res Public Health, 2012
The aryl hydrocarbon receptor pathway is a key component of the microRNA-mediated acute myeloid leukemia signalisome
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