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ARP6 Arp6p

ARP6, suf3, APOBEC3DE, actin-related protein 6
This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, H2A, Histone, APOBEC3G, CAN
Papers on ARP6
Gibberellic acid signaling is required for ambient temperature-mediated induction of flowering in Arabidopsis thaliana.
Schmid et al., Tübingen, Germany. In Plant J, Dec 2015
In addition, loss of PIF function only partially suppressed the early flowering phenotype and FT expression of the arp6 mutant, which is defective in H2A.Z deposition.
The actin family protein ARP6 contributes to the structure and the function of the nucleolus.
Harata et al., Sendai, Japan. In Biochem Biophys Res Commun, Sep 2015
ARP6, one of the nuclear ARPs, is part of the Snf-2-related CREB-binding protein activator protein (SRCAP) chromatin remodeling complex, which promotes the deposition of the histone variant H2A.Z into the chromatin.
Regulation of metabolic gene clusters in Arabidopsis thaliana.
Osbourn et al., Norwich, United Kingdom. In New Phytol, 2015
We show that the transcript levels of genes within two metabolic clusters are coordinately reduced in an arp6 and h2a.z background.
Yeast Actin-Related Protein ARP6 Negatively Regulates Agrobacterium-Mediated Transformation of Yeast Cell.
Pan et al., Guangzhou, China. In Biomed Res Int, 2014
Here our genetic screening of yeast knockout mutants identified a yeast actin-related protein ARP6 as a negative regulator of AMT.
ACTIN-RELATED PROTEIN6 Regulates Female Meiosis by Modulating Meiotic Gene Expression in Arabidopsis.
Palanivelu et al., Shanghai, China. In Plant Cell, 2014
Here, we show that Arabidopsis thaliana plants deficient in ACTIN-RELATED PROTEIN6 (ARP6), a subunit of the SWR1 ATP-dependent chromatin-remodeling complex, exhibit defects in prophase I of female meiosis.
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.
Pathak et al., Frederick, United States. In J Mol Biol, 2014
Specifically, APOBEC3DE, APOBEC3F, APOBEC3G, and APOBEC3H haplotypes II, V, and VII provide protection against HIV-1Δvif through hypermutation of the viral genome, inhibition of reverse transcription, and inhibition of viral DNA integration into the host genome.
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters.
Henderson et al., Cambridge, United Kingdom. In Nat Genet, 2013
Pollen typing, segregation and cytogenetic analysis showed decreased numbers of crossovers in the arp6 H2A.Z deposition mutant at multiple scales.
APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages.
Pathak et al., Frederick, United States. In J Virol, 2013
We observed significant inhibition of HIV-1Δvif produced in 293T cells in the presence of APOBEC3DE (A3DE), APOBEC3F (A3F), APOBEC3G (A3G), and APOBEC3H haplotype II (A3H HapII) but not APOBEC3B (A3B), APOBEC3C (A3C), or APOBEC3H haplotype I (A3H HapI).
Plant immune response to pathogens differs with changing temperatures.
He et al., College Station, United States. In Nat Commun, 2012
The Arabidopsis arp6 and hta9hta11 mutants, phenocopying plants grown at elevated temperatures, exhibit enhanced PTI and yet reduced ETI responses.
Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif.
Yu et al., Changchun, China. In Retrovirology, 2012
Vif antagonizes the antiviral activity of human cytidine deaminase APOBEC3 proteins that confer the non-permissive phenotype by tethering them (APOBEC3DE/3F/3G) to the Vif-CBF-β-ElonginB-ElonginC-Cullin5-Rbx (Vif-CBF-β-EloB-EloC-Cul5-Rbx) E3 complex to induce their proteasomal degradation.
Identification of regulators required for the reactivation of FLOWERING LOCUS C during Arabidopsis reproduction.
Choi et al., Seoul, South Korea. In Planta, 2011
actin-related protein 6 (arp6), arabidopsis trithorax 1 (atx1), arabidopsis trithorax-related 7 (atxr7), and atx1 atxr7 double mutants also caused the downregulation of FLC during seed development, but the defects were less severe than those in mutants for the FRI- and Paf1-complexes.
Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif.
Pathak et al., Frederick, United States. In J Virol, 2010
Human APOBEC3F (hA3F) and human APOBEC3G (hA3G) are potent anti-human immunodeficiency virus (anti-HIV) host factors that suppress viral replication by hypermutating the viral genome, inhibiting reverse transcription, and hindering integration.
Nuclear actin-related proteins at the core of epigenetic control.
McKinney et al., Athens, United States. In Plant Signal Behav, 2010
We recently argued that most nuclear ARPs evolved directly from actin prior to the divergence of the eukaryotic kingdoms and did not evolve from pre-existing ARPs.2 Arabidopsis plants defective in nuclear ARP4, ARP5, ARP6, or ARP7 have extreme developmental phenotypes.
Histone H2A.Z regulates the expression of several classes of phosphate starvation response genes but not as a transcriptional activator.
Meagher et al., Athens, United States. In Plant Physiol, 2010
ARP6 is required for proper H2A.Z deposition at a number of Pi starvation response (PSR) genes in Arabidopsis. [ARP6]
Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif.
Glashoff et al., Stellenbosch, South Africa. In Arch Virol, 2008
The antiviral activity of APOBEC3B and APOBEC3DE has also been described.
Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins.
Yu et al., Baltimore, United States. In Plos One, 2007
Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins.
Arabidopsis homologs of components of the SWR1 complex regulate flowering and plant development.
Lee et al., Seoul, South Korea. In Development, 2007
Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1) are homologs of SWC6, ARP6 and SWR1 with roles in development, including floral repression through full activation of FLOWERING LOCUS C
SEF, a new protein required for flowering repression in Arabidopsis, interacts with PIE1 and ARP6.
Reyes et al., Sevilla, Spain. In Plant Physiol, 2007
The identification and characterization of SERRATED LEAVES AND EARLY FLOWERING (SEF) in A. thaliana and its interactions with other proteins, including ATARP6 and PIE1, are reported.
EARLY IN SHORT DAYS 1 (ESD1) encodes ACTIN-RELATED PROTEIN 6 (AtARP6), a putative component of chromatin remodelling complexes that positively regulates FLC accumulation in Arabidopsis.
Jarillo et al., Madrid, Spain. In Development, 2006
ESD1 encodes ATARP6, a putative component of chromatin remodelling that positively regulates FLC accumulation.
The actin-related proteins.
Mooseker et al., New Haven, United States. In Curr Opin Cell Biol, 1996
In the past year, different arps have been linked to functions mediated by actin filaments (arp2 and arp3), microtubules (arp1) and the structural elements of chromatin (arp4 and arp6).
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