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Mesencephalic astrocyte-derived neurotrophic factor

MANF, ARP, mesencephalic astrocyte-derived neurotrophic factor, ARMET
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Actin, ACID, CAN, COUP Transcription Factor I, Arp2
Papers on MANF
Genome-wide analysis of tunicamycin-induced endoplasmic reticulum stress response and the protective effect of endoplasmic reticulum inhibitors in neonatal rat cardiomyocytes.
He et al., Beijing, China. In Mol Cell Biochem, Feb 2016
Six not well-known genes (Hyou1, Herpud1, Manf, Creld2, Sdf2l1, and Slc3a2) were highlighted to be involved in ER stress.
Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease.
Saarma et al., Helsinki, Finland. In Febs Lett, Jan 2016
Neurotrophic factors (NTFs), cerebral DA NTF (CDNF) and mesencephalic astrocyte-derived NTF (MANF) form a novel family of evolutionarily conserved, endoplasmic reticulum (ER) located and secreted NTFs.
The renal protective effects of Anoectochilus roxburghii polysaccharose on diabetic mice induced by high-fat diet and streptozotocin.
Yi et al., Xiamen, China. In J Ethnopharmacol, Jan 2016
Considering that Anoectochilus roxburghii polysaccharose (ARP) is the main constituent of Anoectochilus roxburghii, the present study is aimed to investigate the renal protection of ARP and its possible mechanism in diabetic mice.
The Entamoeba histolytica, Arp2/3 Complex Is Recruited to Phagocytic Cups through an Atypical Kinase EhAK1.
Bhattacharya et al., New Delhi, India. In Plos Pathog, Dec 2015
Here we show that EhARPC1, an essential subunit of the actin branching complex Arp 2/3 is recruited to the phagocytic initiation sites by EhAK1.
Differential Genomic Effects on Signaling Pathways by Two Different CeO2 Nanoparticles in HepG2 Cells.
Kitchin et al., In J Nanosci Nanotechnol, Dec 2015
M is more active than L in respect to altering the pathways of mitochondrial dysfunction, acute phase response, apoptosis, 14-3-3 mediated signaling, remodeling of epithelial adherens junction signaling, actin nucleation by ARP-WASP complex, altered TCA cycle and elevated fatty acid concentrations by metabolomics.
Current disease modifying approaches to treat Parkinson's disease.
Saarma et al., Helsinki, Finland. In Cell Mol Life Sci, Dec 2015
In particular, studies employing glial cell line-derived neurotrophic factor (GDNF) and its family member neurturin (NRTN), as well as the recently described cerebral dopamine neurotrophic factor (CDNF) and the mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown positive results in protecting and repairing dopaminergic neurons in various models of PD.
Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy.
Airavaara et al., Helsinki, Finland. In Hum Gene Ther, Aug 2015
In particular, glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), cerebral dopamine neurotrophic factor, and mesencephalic astrocyte-derived neurotrophic factor have shown great potential to restore dopamine neurocircuitry.
[Alternative oxidase in industrial fungi].
Li et al., In Sheng Wu Gong Cheng Xue Bao, 2015
Based on non-phosphorylating electron transport process, alternative respiration pathway (ARP) acts as an energy overflow, which can balance carbon metabolism and electron transport, allow the continuance of tricarboxylic acid cycle without the formation of ATP, and permit the turnover of carbon skeletons.
Cellular protrusions--lamellipodia, filopodia, invadopodia and podosomes--and their roles in progression of orofacial tumours: current understanding.
Siar et al., Kuala Lumpur, Malaysia. In Asian Pac J Cancer Prev, 2014
Invadopodia-associated protein markers consisted of 129 proteins belonging to different functional classes including WASP, NWASP, cortactin, Src kinase, Arp 2/3 complex, MT1-MMP and F-actin.
Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.
Arumäe et al., Helsinki, Finland. In Cell Death Dis, 2014
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a prosurvival protein that protects the cells when applied intracellularly in vitro or extracellularly in vivo.
An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration.
Devreotes et al., Baltimore, United States. In Nat Cell Biol, 2013
However, we find that the cytoskeletal network, involving SCAR/WAVE, Arp 2/3 and actin-binding proteins, is capable of generating only rapid oscillations and undulations of the cell boundary.
Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.
Doroudgar et al., San Diego, United States. In J Biol Chem, 2012
sarcoplasmic/endoplasmic reticulum calcium depletion triggered MANF secretion by decreasing its retention
Intracellular trafficking and secretion of mouse mesencephalic astrocyte-derived neurotrophic factor.
Kiuchi et al., Gifu, Japan. In Mol Cell Biochem, 2012
Secretion of MANF is regulated via COPII-mediated transport and that its C-terminus could be responsible for its retention in the endoplasmic reticulum through GRP78.
Altered expression of Armet and Mrlp51 in the oocyte, preimplantation embryo, and brain of mice following oocyte in vitro maturation but postnatal brain development and cognitive function are normal.
Jin et al., Hangzhou, China. In Reproduction, 2011
The change in Armet expression lasted while the change of Mrpl51 disappeared after birth.
Coup d'Etat: an orphan takes control.
Tsai et al., United States. In Endocr Rev, 2011
Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2).
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.
Permi et al., Helsinki, Finland. In J Biol Chem, 2011
MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury.
Harvey et al., Baltimore, United States. In Exp Neurol, 2010
Pretreatment with adeno-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Pollard et al., New Haven, United States. In Nature, 2009
Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements.
Delta traffic takes a sh-Arp turn.
Schejter, In Nat Cell Biol, 2009
In the Notch pathway, the transmembrane ligand Delta is internalized and then re-established on the surface of signal-sending cells to allow the productive binding and activation of the Notch receptor on neighbouring cells.
The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility.
Way et al., London, United Kingdom. In Nature, 2009
Taking advantage of this, we have analysed the dynamics of neuronal Wiskott-Aldrich syndrome protein (N-WASP), WASP-interacting protein (WIP), GRB2 and NCK, which are required to stimulate actin-related protein (ARP)2/3-complex-dependent actin-based motility of vaccinia virus, using fluorescence recovery after photobleaching.
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