Current disease modifying approaches to treat Parkinson's disease.
Helsinki, Finland. In Cell Mol Life Sci, Dec 2015
In particular, studies employing glial cell line-derived neurotrophic factor (GDNF) and its family member neurturin (NRTN), as well as the recently described cerebral dopamine neurotrophic factor (CDNF) and the mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown positive results in protecting and repairing dopaminergic neurons in various models of PD.
[Alternative oxidase in industrial fungi].
In Sheng Wu Gong Cheng Xue Bao, 2015
Based on non-phosphorylating electron transport process, alternative respiration pathway (ARP) acts as an energy overflow, which can balance carbon metabolism and electron transport, allow the continuance of tricarboxylic acid cycle without the formation of ATP, and permit the turnover of carbon skeletons.
Coup d'Etat: an orphan takes control.
United States. In Endocr Rev, 2011
Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2).
Delta traffic takes a sh-Arp turn.
In Nat Cell Biol, 2009
In the Notch pathway, the transmembrane ligand Delta is internalized and then re-established on the surface of signal-sending cells to allow the productive binding and activation of the Notch receptor on neighbouring cells.