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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Plakophilin 1

Armadillo, plakophilin 1, plakophilin-2, PKP2, plakophilin, PKP1
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: CAN, E-cadherin, HAD, TCF, ACID
Papers using Armadillo antibodies
Defining desmosomal plakophilin-3 interactions
van Roy Frans et al., In The Journal of Cell Biology, 1994
... tag (Oncogene Research Products), mouse anti-CK18 antibody RGE53 (Euro-Diagnostics), mouse anti-DP and anti-PKP2 (Progen), mouse anti-PKP1 (Zymed Laboratories), polyclonal OctA-Probe™ (Santa Cruz Biotechnology, Inc.) ...
Papers on Armadillo
Phosphorylation and isoform use in p120-catenin during development and tumorigenesis.
McCrea et al., Seoul, South Korea. In Biochim Biophys Acta, Jan 2016
P120-catenin is essential to vertebrate development, modulating cadherin and small-GTPase functions, and growing evidence points also to roles in the nucleus.
Identification of Interacting Motifs Between Armadillo Repeat Containing 1 (ARC1) and Exocyst 70 A1 (Exo70A1) Proteins in Brassica oleracea.
Zhu et al., Chongqing, China. In Protein J, Jan 2016
UNASSIGNED: In order to identify the functional domains which regulate the interaction between the self-incompatibility proteins armadillo repeat containing 1 (ARC1) and exocyst 70 A1 (Exo70A1) in Brassica oleracea, fragments containing selected motifs of ARC1 (ARC1210, ARC1246, ARC1279, ARC1354) and site-specific mutants with substitutions at possible interaction sites (ARC1354m, ARC1664m) were PCR amplified and inserted into pGADT7, while coding sequences from Exo70A1 (Exo70A185, Exo70A1) were subcloned into pGBKT7.
Purification and Structural Analysis of Desmoplakin.
Weis et al., Seoul, South Korea. In Methods Enzymol, Dec 2015
Desmoplakin (DP) is an obligate component of desmosomes, where it links the desmosomal cadherin/plakoglobin/plakophilin assembly to intermediate filaments.
Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy.
Pompilio et al., Milano, Italy. In Eur Heart J, Dec 2015
We found that both ACM and control C-MSC express desmosomal genes, with ACM C-MSC showing lower expression of plakophilin (PKP2) protein vs. CONTROLS: Arrhythmogenic cardiomyopathy C-MSC cultured in adipogenic medium accumulated more lipid droplets than controls.
Combination of palmoplantar keratoderma and hair shaft anomalies, the warning signal of severe arrhythmogenic cardiomyopathy: a systematic review on genetic desmosomal diseases.
Hadj-Rabia et al., Paris, France. In J Med Genet, Oct 2015
We delineated three major phenotypes: the PPK-hair shaft anomalies-non-fragile skin subtype (77%), always associated with cardiac involvement; the PPK-hair shaft anomalies-skin fragility-normal cardiac function subtype (19.9%), frequently associated with PKP1 mutations; the PPK-hair shaft anomalies-skin fragility-cardiac involvement subtype (3.1%), always due to DSP mutations.
The Curse of the Nine-Banded Armadillo: Case Report and Review.
Thompson et al., Orlando, United States. In Mil Med, Jul 2015
Hansen's disease (leprosy) is an ancient condition characterized by hypopigmented patches that progress to become plaques with hypoesthesia.
Protein assemblies of sodium and inward rectifier potassium channels control cardiac excitability and arrhythmogenesis.
Jalife et al., Madrid, Spain. In Am J Physiol Heart Circ Physiol, Jul 2015
Emerging evidence also shows that inheritable mutations in plakophilin-2, ankyrin-G, dystrophin, syntrophin, synapse-associated protein-97, and caveolin-3, among others, modify functional expression and/or localization in the cardiac cell of NaV1.5, Kir2.1 or both to give rise to arrhythmogenic diseases.
RhoA activity increased in myocardium of arrhythmogenic cardiomyopathy patients and affected connexin 43 protein expression in HL-1 cells.
Wei et al., Beijing, China. In Int J Clin Exp Med, 2014
One of Rho GTPase, RhoA involves in many pathological processes and is regulated by desmosomal gene PKP2.
Maturation-Based Model of Arrhythmogenic Right Ventricular Dysplasia Using Patient-Specific Induced Pluripotent Stem Cells.
Chen et al., Japan. In Circ J, 2014
Over 50% of affected individuals have desmosome gene mutations, most commonly inPKP2encoding plakophilin-2.
Novel frame-shift mutation in PKP2 associated with arrhythmogenic right ventricular cardiomyopathy: a case report.
Reinhard et al., München, Germany. In Bmc Med Genet, 2014
CASE PRESENTATION: We report a case of newly diagnosed ARVC where genetic testing identified a novel familial frame-shift mutation in the PKP2 gene.
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.
Chen et al., Los Angeles, United States. In Nature, 2013
Over 50% of affected individuals have desmosome gene mutations, most commonly in PKP2, encoding plakophilin-2 (ref.
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
Freeman et al., Worcester, United States. In Science, 2012
Here, we show that loss of the Drosophila Toll receptor adaptor dSarm (sterile α/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wallerian degeneration for weeks after axotomy.
A novel variant in plakophilin-2 gene detected in a family with arrhythmogenic right ventricular cardiomyopathy.
Blomström-Lundqvist et al., Uppsala, Sweden. In J Interv Card Electrophysiol, 2012
While many of the reported ARVC mutations are truncating mutations, the possibly damaging variant found in this family, is a missense alteration affecting a highly conserved residue 506 located in exon 7.
Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma.
Grady et al., Seattle, United States. In Genes Chromosomes Cancer, 2012
PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of Barrett's esophagus to esophageal adenocarcinoma in a subset of patients via decreased desmosome assembly and increased cell motility
Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder cancer.
Kanayama et al., Tokushima, Japan. In Urology, 2012
PKP2 gene upregulation is associated with bladder cancer invasion.
Differential regulation of adherens junction dynamics during apical-basal polarization.
Hong et al., Pittsburgh, United States. In J Cell Sci, 2012
Binding of Arm to DE-cadherin is weaker in polarizing cells than in polarized cells.
Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development.
Peifer et al., Chapel Hill, United States. In Plos One, 2011
Arm is found at the plasma membrane of all epithelial cells, as part of the cadherincatenin complex
Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells.
Xi et al., Beijing, China. In Nature, 2008
Clonal analysis shows that the main downstream components of the Wg pathway, including Frizzled, Dishevelled and Armadillo, are autonomously required for ISC self-renewal.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Basler et al., Zürich, Switzerland. In Cell, 2006
Data show that Drosophila Hyrax and its human ortholog, Parafibromin, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity.
Nusse et al., In Nature, 2005
The WntD signal is independent of the common Wnt signalling component Armadillo (beta-catenin).
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