ARLTS1 - a novel tumor suppressor gene.
Buffalo, United States. In Cancer Lett, 2008
A novel tumor suppressor gene [ARLTS1 (ADP-ribosylation factor-like tumor suppressor gene 1)]is found to be altered in human carcinogenesis. It is located in Chromosome 13q14.3.
Tumor suppressor functions of ARLTS1 in lung cancers.
United States. In Cancer Res, 2007
650 transcripts expressed after restoration of ARLTS1 expression were identified in A549 cells, suggesting that pathways involved in cell survival, proliferation, signaling, and development mediate the effects of wild-type ARLTS1 in lung cancer.
Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer.
Columbus, United States. In Cancer Res, 2006
ARLTS1 is a tumor suppressor gene initially described as a low-penetrance cancer gene: a truncated Trp149Stop (MUT) polymorphism is associated with general familial cancer aggregation and, particularly, high-risk familial breast cancer.
ARLTS1 variants and melanoma risk.
Heidelberg, Germany. In Int J Cancer, 2006
While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37-1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05-1.95, p = 0.02)